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Explore antimicrobial resistance genes from the literature

FabL2

enoyl-acyl carrier protein reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to FabL2

Browse AMR rules for FabL2

Overview

Drug Classes: triclosan
Organisms: Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A128V	-	-	Escherichia coli	triclosan	Reslit	Candidate

Papers1

1

Biochemical and Structural Insights Concerning Triclosan Resistance in a Novel YX(7)K Type Enoyl-Acyl Carrier Protein Reductase from Soil Metagenome.

PMID 31659200 · 2019

The A128V mutation increases triclosan resistance.

Mutation Information

Protein Change: A128V
Organisms: Escherichia coli
Confers Resistance To: triclosan
Validation Method: site-directed mutagenesis and TCL resistance assay
Source Database: Reslit