PA1438

two-component sensor kinase

Overview

Mechanism: upregulation of MexMN pump gene expression and a >50-fold upregulation of PA1438 and the neighboring response regulator gene, PA1437
Drug Classes: carbenicillin|aztreonam|carumonam
Organisms: Pseudomonas aeruginosa
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
L172P	-	upregulation of MexMN pump gene expression and a >50-fold upregulation of PA1438 and the neighboring response regulator gene, PA1437	Pseudomonas aeruginosa	carbenicillin\|aztreonam\|carumonam	Reslit	Candidate

Papers1

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression.

PMID 30420483 · 2019

mutation in PA1438 reduces susceptibility to D13-9001

Mutation Information

PA1438: p.L172P

Protein Change: L172P
Organisms: Pseudomonas aeruginosa
Confers Resistance To: carbenicillin|aztreonam|carumonam
Effect on Function: upregulation of MexMN pump gene expression and a >50-fold upregulation of PA1438 and the neighboring response regulator gene, PA1437
Validation Method: genomic sequencing and mutagenesis
Source Database: Reslit

PA1438

Mutations

Mutation Information

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PA1438

Mutations

Mutation Information