Browse AMR Genes

Explore antimicrobial resistance genes from the literature

PA4089

short-chain dehydrogenase involved in fatty acid biosynthesis

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to PA4089

Browse AMR rules for PA4089

Overview

Mechanism: deleterious
Drug Classes: colistin
Organisms: Pseudomonas aeruginosa
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V62E	-	deleterious	Pseudomonas aeruginosa	colistin	Reslit	Candidate

Papers1

1

Evolved resistance to colistin and its loss due to genetic reversion in Pseudomonas aeruginosa.

PMID 27150578 · 2016

Mutation Information

Protein Change: V62E
Organisms: Pseudomonas aeruginosa
Confers Resistance To: colistin
Effect on Function: deleterious
Validation Method: gene knock-out and complementation experiments
Source Database: Reslit