PPE54

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putative membrane protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to PPE54

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: resistance to bedaquiline
Validation Method: feature analysis and alignment to reference genome
Drug Classes: bedaquiline
Organisms: Mycobacterium tuberculosis
Geographic Location: Europe|Asia|North America|Africa|South America|Australia|Oceania
Papers: 1
Databases: Reslit

Papers1

A comparative study of antibiotic resistance patterns in Mycobacterium tuberculosis.

PMID 39934219 · 2025

The study identifies several genes associated with antibiotic resistance in Mycobacterium tuberculosis, including rpoB, embB, katG, rpsL, gyrA, rrs, rplC, and PPE54, which are linked to resistance against various antibiotics such as rifampicin, ethambutol, isoniazid, fluoroquinolones, aminoglycosides, and linezolid.

Gene Information

Gene Name: PPE54
Allele: PPE54
Encodes: putative membrane protein
Source Database: Reslit
Mechanism: resistance to bedaquiline
Confers Resistance To: bedaquiline
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Europe|Asia|North America|Africa|South America|Australia|Oceania
Validation Method: feature analysis and alignment to reference genome

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PPE54

Gene Information

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PPE54

Gene Information