Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ABC transporter ATP-binding protein
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Rv0194 | Reslit | 4 | fluoroquinolones, para aminosalicylic acid +2 | Mycobacterium tuberculosis | Russia, Belarus|South Africa|South Korea|India, India | 2013, 2018, 2019, 2020 | CP002992|SRA051492|AIIE01000000 | - |
| rv0194 | Reslit | 1 | ampicillin, phenicols +2 | Mycobacterium tuberculosis | - | 2012 | - | - |
Comparative genomic analysis of Mycobacterium tuberculosis drug resistant strains from Russia.
The study identified several genetic mutations associated with drug resistance in Mycobacterium tuberculosis strains from Russia, including mutations in rpoB, katG, embB, pncA, rrs, rpsL, ethA, ndhA, Rv0194, Rv1634, and Rv2688c, which confer resistance to rifampicin, isoniazid, ethambutol, pyrazinamide, kanamycin, amikacin, streptomycin, ethionamide, and fluoroquinolone.
The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance.
The paper discusses the role of transport mechanisms, particularly efflux pumps, in Mycobacterium tuberculosis drug resistance and tolerance, highlighting the importance of efflux pump activity in reducing drug susceptibility.
Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.
The study identifies 33 known AMR genes and 24 new genetic signatures of AMR in Mycobacterium tuberculosis using machine learning and structural analysis. It also reveals 97 epistatic interactions across 10 resistance classes and provides mechanistic insights into the selection of these genes.
Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India.
The study identified that the efflux pump genes mmpL5, Rv0194, and Rv1250 were upregulated in rifampicin-resistant Mycobacterium tuberculosis isolates, suggesting their potential role in mediating rifampicin resistance.
The ATP-Binding Cassette (ABC) Transport Systems in Mycobacterium tuberculosis: Structure, Function, and Possible Targets for Therapeutics.
This review discusses the structure, function, and potential therapeutic targeting of ABC transporters in Mycobacterium tuberculosis, emphasizing their roles in nutrient import, drug efflux, and virulence.
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