Rv0986

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ATP-binding cassette transporter

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UniProt

Protein entries specific to Rv0986

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Validation StatusCandidate

Overview

Validation Method: transposon mutagenesis
Drug Classes: rifampicin
Organisms: Mycobacterium bovis BCG, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Identification of gene targets that potentiate the action of rifampicin on Mycobacterium bovis BCG.

PMID 39150447 · 2024

The study identified genes involved in cell wall synthesis, transport, and signaling pathways that contribute to rifampicin resistance in Mycobacterium bovis BCG. Key genes include chp2, pknE, thrE, fabD, iniB, and mce1R, which were found to enhance susceptibility when mutated.

Gene Information

Gene Name: Rv0986
Allele: Rv0986
Encodes: ATP-binding cassette transporter
Source Database: Reslit
Confers Resistance To: rifampicin
Organisms Tested In: • Mycobacterium bovis BCG
• Mycobacterium tuberculosis
Validation Method: transposon mutagenesis
Sequence Accession: PRJNA1112803

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Rv0986

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Rv0986

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