Rv1152

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transcriptional regulator

NCBI Pathogen Isolates

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UniProt

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AMR Rules

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Validation StatusCandidate

Overview

Mechanism: negative regulation of vancomycin responsive genes
Validation Method: overexpression and deletion studies
Drug Classes: vancomycin
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Mycobacterium tuberculosis Rv1152 is a Novel GntR Family Transcriptional Regulator Involved in Intrinsic Vancomycin Resistance and is a Potential Vancomycin Adjuvant Target.

PMID 27349953 · 2016

Rv1152 is a GntR family transcriptional regulator that negatively regulates vancomycin responsive genes, leading to reduced susceptibility to vancomycin in Mycobacterium smegmatis and Mycobacterium tuberculosis.

Gene Information

Gene Name: Rv1152
Allele: Rv1152
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: negative regulation of vancomycin responsive genes
Confers Resistance To: vancomycin
Organisms Tested In: • Mycobacterium smegmatis
• Mycobacterium tuberculosis
Validation Method: overexpression and deletion studies

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Rv1152

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Rv1152

Gene Information