Rv1339

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cyclic nucleotide-degrading phosphodiesterase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to Rv1339

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Validation StatusCandidate

Overview

Mechanism: multidrug tolerance
Validation Method: transposon mutant screen and Tn-seq analysis
Drug Classes: rifampicin, streptomycin
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Genetic determinants of Mycobacterium tuberculosis adaptation and drug efficacy during stationary phase growth.

PMID 40793863 · 2025

The study identifies genes involved in Mycobacterium tuberculosis adaptation to stationary phase and drug efficacy, highlighting the role of lipid metabolism and specific genes like katG, rv1339, glpK, mce4, and pssA in drug resistance and tolerance.

Gene Information

Gene Name: Rv1339
Allele: rv1339
Encodes: cyclic nucleotide-degrading phosphodiesterase
Source Database: Reslit
Mechanism: multidrug tolerance
Confers Resistance To: rifampicinstreptomycin
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: transposon mutant screen and Tn-seq analysis
Sequence Accession: OEP00006176

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Rv1339

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Rv1339

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