Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
putative permease
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G376D | - | - | Mycobacterium tuberculosis | clofazimine | Reslit | Candidate |
| R409Q | - | - | Mycobacterium tuberculosis | bedaquilinebedaquiline|clofazimine | Reslit | Candidate |
| V351A | - | - | - | clofazimine | Reslit | Candidate |
| M245L | - | - | Mycobacterium tuberculosis | bedaquiline | Reslit | Candidate |
| D286G | - | - | Mycobacterium tuberculosis | clofazimine | Reslit | Candidate |
| - | - | - | bedaquiline | Reslit | Candidate | |
| - | - | - | clofazimine | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| rv1979c | Reslit | 1 | clofazimine | Mycobacterium tuberculosis H37Rv | - | 2015 | - | - |
| Rv1979c | Reslit | 1 | clofazimine | Mycobacterium tuberculosis | - | 2020 | - | - |
Identification of novel mutations associated with clofazimine resistance in Mycobacterium tuberculosis.
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.
This study identifies numerous mutations in genes associated with resistance to bedaquiline, clofazimine, linezolid, delamanid, and pretomanid in Mycobacterium tuberculosis, highlighting the genetic basis of resistance to these drugs.
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