Rv2170

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putative acetyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to Rv2170

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: acetylation of isoniazid
Validation Method: purified recombinant protein acetylated INH, HPLC and LC-MS analysis, drug susceptibility assay, confocal analysis
Drug Classes: isoniazid
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis
Papers: 1
Databases: Reslit

Papers1

Acetylation of Isoniazid Is a Novel Mechanism of Isoniazid Resistance in Mycobacterium tuberculosis.

PMID 33106268 · 2020

Rv2170, a putative acetyltransferase in Mycobacterium tuberculosis, acetylates isoniazid (INH), rendering it ineffective and contributing to INH resistance.

Gene Information

Gene Name: Rv2170
Allele: Rv2170
Encodes: putative acetyltransferase
Source Database: Reslit
Mechanism: acetylation of isoniazid
Confers Resistance To: isoniazid
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium smegmatis
Validation Method: purified recombinant protein acetylated INH, HPLC and LC-MS analysis, drug susceptibility assay, confocal analysis

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Rv2170

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Rv2170

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