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Rv2535

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to Rv2535

Browse AMR rules for Rv2535

Overview

Mechanism: frameshift mutation
Drug Classes: bedaquiline
Organisms: Mycobacterium tuberculosis
Papers: 1
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R271fs	-	frameshift mutation	Mycobacterium tuberculosis	bedaquiline	Card Database	Candidate
A15fs	-	frameshift mutation	Mycobacterium tuberculosis	bedaquiline	Card Database	Candidate
L44P	-	single resistance variant	Mycobacterium tuberculosis	bedaquiline	Card Database	Candidate

Papers1

1

Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.

PMID 27185800 · 2016

Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline; CARD accession: CARD:3007692

Mutation Information

Rv2535: p.R271fs Rv2535: p.A15fs Rv2535: p.L44P

Protein Change: R271fs, A15fs, L44P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: bedaquiline
Effect on Function: frameshift mutation; single resistance variant
Source Database: Card Database