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WalKR

two-component system

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to WalKR

Browse AMR rules for WalKR

Overview

Drug Classes: vancomycin
Organisms: Staphylococcus aureus
Papers: 1
Mutations: 4

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G223D	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate
K208R	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate
H364R	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate
S221P	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate

Papers1

1

Crosstalk involving two-component systems in Staphylococcus aureus signaling networks.

PMID 38456702 · 2024

Mutations in WalKR contribute to resistance against cell-wall-inhibiting antibiotics.

Mutation Information

WalKR: p.G223D WalKR: p.K208R WalKR: p.H364R WalKR: p.S221P

Protein Change: G223D, K208R, H364R, S221P
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: reported in cited literature
Source Database: Reslit