Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside 2'-N-acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AAC(2')-Ia | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | aminoglycosides, PLAZOMICIN +4 | Providencia stuartii +4 | Italy, China, Egypt | 1993, 2001, 2010, 2020, 2023, 2024, 2025 | JABLTB000000000|JABLTC000000000 | AAA03550.1 |
| aac(2') | Reslit | 4 | amikacin, kanamycin +2 | Mycobacterium abscessus +2 | - | 2017, 2018, 2021, 2022 | PRJNA655109|GSE163621 | - |
| aac2 | Reslit | 1 | aminoglycosides | human clinical isolate of Salmonella | Northern Italy | 2020 | PRJEB36291 | - |
| aac(2')-If | Reslit | 1 | neomycin | Providencia wenzhouensis R33 +1 | China | 2021 | MW984427|CP003488.1|CP066315.1|CP031123.2|CP053042.1 | - |
| aac(2′)-If | Reslit | 1 | neomycin, gentamicin +3 | Providencia wenzhouensis R33 | China | 2021 | MW984427|CP003488.1|CP066315.1|CP031123.2|CP053042.1 | - |
| aac 2 | Reslit | 1 | aminoglycosides | Escherichia coli | Saudi Arabia | 2022 | - | - |
| AAC2' | Reslit | 1 | aminoglycosides | Mycobacterium tuberculosis | - | 2022 | - | - |
| aac(2')-Ia | ResFinder Database | 1 | DIBEKACIN, NETILMICIN +2 | Providencia stuartii | - | 1993 | L06156 | - |
Overexpression and characterization of the chromosomal aminoglycoside 2′-N-acetyltransferase of Providencia stuartii.
The study characterizes the chromosomal aminoglycoside 2′-N-acetyltransferase (AAC(2′)-Ia) from Providencia stuartii, demonstrating its role in O-acetylation of peptidoglycan rather than direct aminoglycoside resistance.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene.
The study identifies erm(41) and eis2 as genes involved in clarithromycin and amikacin resistance in Mycobacterium abscessus, mediated by the whiB7 gene.
Kanamycin and its derivative, arbekacin: significance and impact.
The paper discusses the significance of kanamycin (KM) and its derivative, arbekacin (ABK), highlighting their roles in combating antibiotic resistance, particularly in methicillin-resistant Staphylococcus aureus (MRSA). It describes the mechanisms of resistance to aminoglycosides, including the role of genes such as aac(6')/aph(2"), aad(6), aac(3), and aac(2').
Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture.
The study characterizes the resistome of the healthy oral microbiome, identifying several resistance genes including mefA, ermB, tetB, aac1, SHV, QnrD, and msrA, which confer resistance to macrolides, tetracyclines, aminoglycosides, beta-lactams, and fluoroquinolones.
Genomic Analysis of two NDM-1 Providencia stuartii Strains Recovered from a Single Patient.
The study identified 13 resistance genes, including beta-lactamases (blaOXA-1, blaTEM-1, blaNDM-1), aminoglycoside-modifying enzymes (aphA6, aac(3)-IId, aac(2')-Ia, aac(6')-Ib-cr5), sulfonamide resistance (sul1), chloramphenicol resistance (catB3, catA3), rifampicin resistance (arr3), bleomycin resistance (ble), and tetracycline resistance (tet(B)) in NDM-1-producing Providencia stuartii strains.
Basic and applied research on multiple aminoglycoside antibiotic resistance of actinomycetes: an old-timer's recollection.
The study identifies several aminoglycoside resistance genes, including aac(3), aac(2'), aac(6'), and aac(1), which confer resistance to various aminoglycoside antibiotics. These genes were characterized through biochemical analyses and their resistance mechanisms were elucidated.
RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus.
The study identifies several genes involved in antibiotic resistance in Mycobacterium abscessus, including erm(41) for macrolide resistance, WhiB7 for general resistance to ribosome-targeting antibiotics, sigH for tigecycline resistance, cydA for clofazimine tolerance, and various aminoglycoside-modifying enzymes like aac(2'), aph(3'), and eis2.
Identification and Characterization of a Novel Chromosomal Aminoglycoside 2′-N-Acetyltransferase, AAC(2′)-If, From an Isolate of a Novel Providencia Species, Providencia wenzhouensis R33.
A novel chromosomal aminoglycoside resistance gene, aac(2')-If, was identified in Providencia wenzhouensis R33. The gene confers resistance to ribostamycin and neomycin.
Identification and Characterization of a Novel Chromosomal Aminoglycoside 2′-N-Acetyltransferase, AAC(2′)-If, From an Isolate of a Novel Providencia Species, Providencia wenzhouensis R33.
A novel chromosomal aminoglycoside resistance gene, aac(2')-If, was identified in Providencia wenzhouensis R33. The gene confers resistance to ribostamycin and neomycin.
Bacterial diversity and the antimicrobial resistome in the southwestern highlands of Saudi Arabia.
The study identified 102 antimicrobial resistance genes (ARGs) in the soil microbiota of the southwestern highlands of Saudi Arabia, primarily associated with multidrug resistance, macrolide, tetracycline, glycopeptide, bacitracin, and beta-lactam antibiotic resistance. qPCR confirmed the detection of 18 clinically important ARGs.
Mycobacterium Time-Series Genome Analysis Identifies AAC2' as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism.
The study identifies AAC2' as a potential drug target in Mycobacterium tuberculosis, highlighting its role in aminoglycoside resistance through acetylation. Naloxone is proposed as a potential bait drug that binds to AAC2', potentially enhancing the efficacy of aminoglycosides by competing for the same binding site.
Genome-Based Retrospective Analysis of a Providencia stuartii Outbreak in Rome, Italy: Broad Spectrum IncC Plasmids Spread the NDM Carbapenemase within the Hospital.
The study identifies the presence of bla NDM-1 and rmtC genes on an IncC plasmid in Providencia stuartii, contributing to extensive drug resistance. Additional resistance genes such as aac(6')-Ib3, sul1, bla CMY-6, tet(B), catA3, and aac(2')-Ia were also found.
Genomic revisitation and reclassification of the genus Providencia.
The study identifies a novel species, Providencia zhijiangensis, and reveals extensive antibiotic resistance gene (ARG) diversity within the genus, with particular emphasis on carbapenem resistance genes such as blaIMP-27 and blaNDM-1. It also notes the prevalence of aac(2')-Ia, tet(B), and catA3 in P. stuartii, contributing to its multidrug-resistant profile.
Providencia pseudovermicola sp. nov.: redefining Providencia vermicola and unveiling multidrug-resistant strains from diabetic foot ulcers in Egypt.
The study identifies multiple multidrug-resistant genes in Providencia pseudovermicola sp. nov., including bla CTX-M-14, bla CMY-6, bla NDM-1, qnrD1, aadA, armA, msrE, mphE, lnuF, rmtC, aac(6')-Ib10, sul1, aph(3')-Ia, qacEΔ1, and dfrA1, highlighting the significance of these genes in conferring resistance to various antibiotics.
Characterization and transcriptional regulation of the 2'-N-acetyltransferase gene from Providencia stuartii.
Characterization and transcriptional regulation of the 2'-N-acetyltransferase gene from Providencia stuartii.
Characterization and transcriptional regulation of the 2'-N-acetyltransferase gene from Providencia stuartii.
Characterization and transcriptional regulation of the 2'-N-acetyltransferase gene from Providencia stuartii.
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