Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
AAC(2')
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AAC(2')-Ic | Card DatabaseReference Gene CatalogReslit | 9 | aminoglycosides, neomycin +2 | Mycobacterium tuberculosis H37Rv +5 | Italy | 1997, 2008, 2010, 2022, 2023 | AL123456.3 | CCP42991.1 |
| aac(2')-Ic | ResFinder Database | 1 | DIBEKACIN, NETILMICIN +2 | Mycobacterium tuberculosis H37Rv | - | - | U72714 | - |
Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray.
The study characterizes the aminoglycoside acetyltransferases AAC(2')-Ic from Mycobacterium tuberculosis and AAC(3)-IV from Escherichia coli, demonstrating their ability to modify aminoglycosides and reduce their binding affinity to the bacterial A-site, thereby contributing to aminoglycoside resistance.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
A soft-computation hybrid method for search of the antibiotic-resistant gene in Mycobacterium tuberculosis for promising drug target identification and antimycobacterial lead discovery.
The study identified mtrA and katG as potential drug targets in Mycobacterium tuberculosis. Computational analysis suggested that carvacrol, limonene, p-Coumaric acid prenyl ester, 4-aminocinnamic acid, and 4-nitrocinnamic acid could act as inhibitors against these targets.
Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis.
The study focuses on the discovery and development of inhibitors targeting the acetyltransferase Eis, which is responsible for aminoglycoside resistance in Mycobacterium tuberculosis. Eis was shown to confer resistance to kanamycin and amikacin.
Genomics insights into a Mycobacterium pinnipedii isolate causing tuberculosis in a captive South American sea lion (Otaria flavescens) from Italy.
The study identified intrinsic resistance genes erm-37 and aac(2')-Ic in a Mycobacterium pinnipedii isolate from a sea lion, conferring resistance to macrolides and aminoglycosides, respectively.
Aminoglycoside 2'-N-acetyltransferase genes are universally present in mycobacteria: characterization of the aac(2')-Ic gene from Mycobacterium tuberculosis and the aac(2')-Id gene from Mycobacterium smegmatis.
Aminoglycoside 2'-N-acetyltransferase genes are universally present in mycobacteria: characterization of the aac(2')-Ic gene from Mycobacterium tuberculosis and the aac(2')-Id gene from Mycobacterium smegmatis.
No comments yet. Be the first to comment!