aac(3)-IVb

AAC(3)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: cloning in E. coli + disk diffusion
Drug Classes: APRAMYCIN, TOBRAMYCIN, GENTAMICIN, gentamicin, tobramycin
Organisms: Cupriavidus gilardii, Cupriavidus gilardii W2-2, Escherichia coli
Geographic Location: California, USA
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Papers2

PMID N/A

Gene Information

Gene Name: aac(3)-IVb
Allele: AAC(3)-IVb
Encodes: AAC(3)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Cupriavidus gilardii
Sequence Accession: MN366378.1
Protein Accession: QEQ43476.1
Notes: ARO:3005061

High frequency transfer and horizontal spread of apramycin resistance in calf faecal Escherichia coli.

PMID 15231771 · 2004

Gene Information

Gene Name: aac(3)-IVb
Allele: AAC(3)-IVb
Encodes: aminoglycoside N-acetyltransferase AAC(3)-IVb
Source Database: Reference Gene Catalog
Confers Resistance To: APRAMYCINTOBRAMYCINGENTAMICIN
Organisms Tested In: • Cupriavidus gilardii
Sequence Accession: VSRI01000003.1
Protein Accession: KAA0181672.1

Comparative Genomics Reveals a Well-Conserved Intrinsic Resistome in the Emerging Multidrug-Resistant Pathogen Cupriavidus gilardii.

PMID 31578249 · 2019

The study identifies intrinsic antibiotic resistance genes in Cupriavidus gilardii, including a novel beta-lactamase (blaOXA-837), a new aminoglycoside 3-N-acetyltransferase (aac(3)-IVb), and a novel aminoglycoside 3"-adenylyltransferase (ant(3")-Ib), which contribute to resistance against various antibiotics.

Gene Information

Gene Name: aac(3)-IVb
Allele: AAC(3)-IVb
Encodes: aminoglycoside 3-N-acetyltransferase
Source Database: Reslit
Confers Resistance To: gentamicintobramycin
Organisms Tested In: • Cupriavidus gilardii W2-2
• Escherichia coli
Geographic Location: California, USA
Validation Method: cloning in E. coli + disk diffusion
Sequence Accession: MN313890|MN366378|MN366379|VSRI00000000|VSRI01000000

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aac(3)-IVb

AAC(3)

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to aac(3)-IVb

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Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: cloning in E. coli + disk diffusion
Drug Classes: APRAMYCIN, TOBRAMYCIN, GENTAMICIN, gentamicin, tobramycin
Organisms: Cupriavidus gilardii, Cupriavidus gilardii W2-2, Escherichia coli
Geographic Location: California, USA
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Papers2

PMID N/A

Gene Information

Gene Name: aac(3)-IVb
Allele: AAC(3)-IVb
Encodes: AAC(3)
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Cupriavidus gilardii
Sequence Accession: MN366378.1
Protein Accession: QEQ43476.1
Notes: ARO:3005061

High frequency transfer and horizontal spread of apramycin resistance in calf faecal Escherichia coli.

PMID 15231771 · 2004

Gene Information

Gene Name: aac(3)-IVb
Allele: AAC(3)-IVb
Encodes: aminoglycoside N-acetyltransferase AAC(3)-IVb
Source Database: Reference Gene Catalog
Confers Resistance To: APRAMYCINTOBRAMYCINGENTAMICIN
Organisms Tested In: • Cupriavidus gilardii
Sequence Accession: VSRI01000003.1
Protein Accession: KAA0181672.1

Comparative Genomics Reveals a Well-Conserved Intrinsic Resistome in the Emerging Multidrug-Resistant Pathogen Cupriavidus gilardii.

PMID 31578249 · 2019

Gene Information

Gene Name: aac(3)-IVb
Allele: AAC(3)-IVb
Encodes: aminoglycoside 3-N-acetyltransferase
Source Database: Reslit
Confers Resistance To: gentamicintobramycin
Organisms Tested In: • Cupriavidus gilardii W2-2
• Escherichia coli
Geographic Location: California, USA
Validation Method: cloning in E. coli + disk diffusion
Sequence Accession: MN313890|MN366378|MN366379|VSRI00000000|VSRI01000000

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aac(3)-IVb

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aac(3)-IVb

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