Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside N-acetyltransferase AAC(3)-VIII
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AAC(3)-VIII | Reference Gene CatalogResFinder DatabaseReslit | 5 | AMINOGLYCOSIDE, UNKNOWN AMINOGLYCOSIDE +4 | Streptomyces fradiae +2 | - | 2005, 2023 | AB211959.1 | BAD95833.1 |
| aac(3)-VIII | ResFinder Database | 1 | UNKNOWN AMINOGLYCOSIDE | Streptomyces fradiae, Streptomyces ribosidificus | - | 2005 | AB211959, AJ843080, AJ748131 | - |
| AAC(3)-VIIIa | Card DatabaseReference Gene CatalogReslit | 3 | AMINOGLYCOSIDE, aminoglycosides | Streptomyces fradiae +1 | - | 1991, 2010 | M55426.1 | AAA26685.1 |
| aac(3)-VIIIa | ResFinder Database | 1 | AMIKACIN, PAROMOMYCIN +5 | Streptomyces fradiae | - | 1991 | M55426 | - |
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.
The ribostamycin biosynthetic gene cluster in Streptomyces ribosidificus: comparison with butirosin biosynthesis.
The ribostamycin biosynthetic gene cluster in Streptomyces ribosidificus: comparison with butirosin biosynthesis.
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773., The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine., The ribostamycin biosynthetic gene cluster in Streptomyces ribosidificus: comparison with butirosin biosynthesis.
Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae.
Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae.
Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.
The study identifies numerous novel aminoglycoside resistance genes (AMEs) in human pathogens through extensive computational screening of bacterial genomes. Twenty-four out of twenty-eight experimentally tested AMEs conferred resistance to aminoglycosides in E. coli, with seventeen exceeding clinical breakpoints.
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