Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside acetyltransferase
Overview
Plasmid-mediated high-level gentamicin resistance among enteric bacteria isolated from pet turtles in Louisiana.
The study identified the aac(3)-IIa and aac(3)-VIa genes as responsible for plasmid-mediated high-level gentamicin resistance in enteric bacteria isolated from pet turtles in Louisiana.
Complete DNA sequence, comparative genomics, and prevalence of an IncHI2 plasmid occurring among extraintestinal pathogenic Escherichia coli isolates.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals.
The study identifies various AMR genes in Salmonella enterica, Escherichia coli, and Enterococcus spp. isolated from U.S. food animals, including aac(3'), aac(6'), aadA, aadA1, aadA2, aadA12, aphAI, aph(3')-Ii-iv, strA, strB, bla CMY-2, bla TEM-1, bla PSE-1, floR, cmlA, cat1, cat2, sul1, sul2, dfr1, dfrA10, tet(A), tet(B), tet(C), tet(D), tet(G), and tetR.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
The study identified numerous aminoglycoside and β-lactam resistance gene homologues in the gut microbiota of healthy adults, indicating that the human gut microbiota serves as a reservoir for antibiotic resistance genes even in the absence of recent antibiotic exposure.
Comparative genomic analysis and virulence differences in closely related salmonella enterica serotype heidelberg isolates from humans, retail meats, and animals.
The study identified several AMR genes and mutations in Salmonella enterica serotype Heidelberg isolates, including bla, aac(6')-Ib, tet(M), qnrS1, and erm(B). Mutations in genes such as SEEHRA37_03221, SEEHRA37_24108, and others were associated with resistance traits.
Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella.
The study identified 65 unique resistance genes in nontyphoidal Salmonella, including bla CTX-M1 and bla SHV2a, which were first reported in retail meat isolates in the United States. The research highlights the effectiveness of whole-genome sequencing in detecting antimicrobial resistance genes and correlating them with phenotypic resistance.
Rapid Aminoglycoside NP Test for Rapid Detection of Multiple Aminoglycoside Resistance in Enterobacteriaceae.
The study presents a rapid colorimetric test for detecting multiple aminoglycoside resistance in Enterobacteriaceae, focusing on the identification of 16S rRNA methylases (armA, rmtB, rmtC, rmtF, rmtG, npmA) and aminoglycoside-modifying enzymes (aac(3)-IV, aac(3)-Ia, aac(3)-V, aph(3')-I, aph(3')-Ib, ant(2'')).
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
The study evaluated the performance of various bioinformatics tools for predicting antimicrobial resistance (AMR) and serotypes of Salmonella enterica using whole-genome sequencing (WGS). It identified several AMR genes and mutations associated with resistance to various antibiotics.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Effects of in ovo probiotic administration on the incidence of avian pathogenic Escherichia coli in broilers and an evaluation on its virulence and antimicrobial resistance properties.
The study identified various antimicrobial resistance genes in APEC isolates, including blaTEM, aac(3)-VIa, aac(3)-VIb, aadA, tetA, tetB, dfr7, qacEΔ, qnr, sul1, intl1, arsC, and merA. These genes conferred resistance to multiple antibiotics such as beta-lactams, aminoglycosides, tetracyclines, quinolones, sulfonamides, and heavy metals.
Rapid and Accurate Detection of Aminoglycoside-Modifying Enzymes and 16S rRNA Methyltransferases by Targeted Liquid Chromatography-Tandem Mass Spectrometry.
The study developed a targeted LC-MS/MS assay for the rapid and accurate detection of aminoglycoside-modifying enzymes and 16S rRNA methyltransferases in E. coli and K. pneumoniae, demonstrating high sensitivity and specificity for detecting resistance mechanisms to gentamicin, tobramycin, and amikacin.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Molecular Characterization and Survive Abilities of Salmonella Heidelberg Strains of Poultry Origin in Brazil.
The study identified the presence of bla CTX-M and bla CMY-2 genes in Salmonella Heidelberg strains, which confer resistance to various beta-lactam antibiotics. These genes were detected in 80% of the strains, highlighting the prevalence of multidrug resistance in poultry-origin Salmonella Heidelberg.
A One-Health Genomic Investigation of Gentamicin Resistance in Salmonella from Human and Chicken Sources in Canada, 2014 to 2017.
The study identified several aminoglycoside-modifying enzymes, including aac(3)-VIa, aac(3)-IId, aac(3)-Id, aac(3)-IVa, aac(3)-IIa, ant(2′′)-Ia, aac(6′)-Ib-cr, aadA2, aadA7, aadA1, ant(3′′)-Ia, aac(6′)-Ib3, and rmtB, as key contributors to gentamicin resistance in Salmonella isolates from both human and chicken sources in Canada.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
Using Targeted Liquid Chromatography-Tandem Mass Spectrometry to Rapidly Detect β-Lactam, Aminoglycoside, and Fluoroquinolone Resistance Mechanisms in Blood Cultures Growing E. coli or K. pneumoniae.
The study developed and validated a targeted LC-MS/MS assay for the rapid detection of β-lactam, aminoglycoside, and fluoroquinolone resistance mechanisms in blood cultures growing E. coli or K. pneumoniae. The assay successfully detected various resistance genes including β-lactamases (SHV, TEM, CTX-M-1-like, OXA-1, CMY-2-like, cAmpC, KPC, OXA-48, NDM, VIM), aminoglycoside-modifying enzymes (AAC(3)-Ia, AAC(3)-II, AAC(3)-IV, AAC(3)-VI, AAC(6′)-Ib, ANT(2′′)-I, APH(3′)-VI), 16S-RMTases (ArmA, RmtB, RmtC, RmtF), and quinolone resistance mechanisms (QnrA, QnrB, AAC(6′)-Ib-cr, and wildtype QRDR of GyrA).
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment.
The study identified a multidrug-resistant ST648 E. coli isolate carrying various AMR genes, including blaCTX-M-2, blaCMY-2, qnrB, tetB, sul1, sul2, aadA1, aac(3)-VIa, and mdfA, highlighting the presence of critical priority pathogens in wild birds.
A One Health Genomic Investigation of Gentamicin Resistance in Escherichia coli from Human and Chicken Sources in Canada, 2014 to 2017.
The study identified several aminoglycoside-modifying enzymes, including aac(3)-IId, aac(3)-VIa, aac(3)-IIa, aac(6′)-Ib-cr, aac(3)-IVa, ant(2″)-Ia, aadA5, aadA1, aadA2, aph(3″)-Ib, and strA, as key contributors to gentamicin and spectinomycin resistance in Escherichia coli from human and chicken sources in Canada.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.
The study identifies numerous novel aminoglycoside resistance genes (AMEs) in human pathogens through extensive computational screening of bacterial genomes. Twenty-four out of twenty-eight experimentally tested AMEs conferred resistance to aminoglycosides in E. coli, with seventeen exceeding clinical breakpoints.
Genomic Features of an MDR Escherichia coli ST5506 Harboring an IncHI2/In229/bla(CTX-M-2) Array Isolated from a Migratory Black Skimmer.
An MDR E. coli ST5506 strain was isolated from a migratory black skimmer, harboring a complex array including bla(CTX-M-2), bla(TEM-1C), aac(3)-VIa, aadA1, aph(3′)-Ia, sul1, dfrA27, and tetA, indicating resistance to various antimicrobials.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
Prevalence, Risk Factors, and Human Health Implications of Salmonella enterica and Campylobacter spp. in Vermont Backyard Poultry.
The study identified various AMR genes and mutations in Salmonella enterica isolates from Vermont backyard poultry, highlighting resistance to streptomycin, tetracycline, sulfonamides, and ampicillin, as well as quinolone resistance through specific mutations.
Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase.
The aac(3)-VIa gene was identified as encoding a novel 3-N-acetyltransferase responsible for resistance to gentamicin in Enterobacter cloacae 88020217.
Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase.
Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase.
Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase.
Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase., Complete DNA sequence, comparative genomics, and prevalence of an IncHI2 plasmid occurring among extraintestinal pathogenic Escherichia coli isolates.
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