Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aacA29b | Reslit | 2 | amikacin, kanamycin +2 | Escherichia coli +1 | France | 2001, 2003 | AF263519|AF263520 | - |
| AAC(6')-Ian | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 14 | TOBRAMYCIN, AMIKACIN +10 | Serratia marcescens +4 | Bolivia, Canada, Brazil, Italy, Nigeria, France|South America|Europe|Asia|North Africa, France | 1997, 2015, 2020, 2021, 2022, 2023, 2024, 2025 | AP014611.1 | BAQ22025.1 |
| aac(6')-Ian | ResFinder Database | 1 | TOBRAMYCIN, AMIKACIN +3 | Serratia marcescens | - | 2015 | AP014611 | - |
Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.
The study identifies two novel aminoglycoside resistance gene cassettes, aacA29a and aacA29b, which confer resistance to several aminoglycosides. Additionally, the bla(VIM-2) gene, which encodes a carbapenem-hydrolyzing beta-lactamase, was characterized in Pseudomonas aeruginosa isolates.
Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase.
The study identifies the aacA29b gene, which confers aminoglycoside resistance by tightly binding the drugs rather than through enzymatic acetylation.
New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.
New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.
New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.
New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.
Mobile Genetic Elements Harboring Antibiotic Resistance Determinants in Acinetobacter baumannii Isolates From Bolivia.
The study identified multiple antibiotic resistance genes in Acinetobacter baumannii isolates from Bolivia, including bla OXA-23, strA, strB, aac(3)-IIa, aac(6')-Ian, sul2, tet(B), bla TEM-1B, and aadB, which contribute to resistance against carbapenems, aminoglycosides, sulfonamides, tetracycline, and beta-lactams.
Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030.
AB030 exhibits resistance to multiple antibiotics, including carbapenems, fluoroquinolones, aminoglycosides, and tigecycline. Key resistance genes include blaOXA-65, blaOXA-23, aac(3)-IIa, aac(6')-Ian, APH(3"-Ib, and APH(6)-Id. Mutations in gyrA, parC, and rpsJ contribute to fluoroquinolone and tigecycline resistance.
Pyomelanin biosynthetic pathway in pigment-producer strains from the pandemic Acinetobacter baumannii IC-5.
The study characterizes the pyomelanin biosynthetic pathway in XDR Acinetobacter baumannii strains, identifying several AMR genes including aac(6')-Ian, aac(3')-IIe, strA, strB, cmlA, sul1, bla TEM-1b, bla ADC-5, bla OXA-65, and bla OXA-23, which contribute to extensive drug resistance.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates.
The study identified various AMR genes in two extensively drug-resistant A. baumannii isolates, including aminoglycoside resistance genes, sulfonamide resistance genes, beta-lactamase genes, and efflux pump genes, highlighting the complexity of their resistance mechanisms.
High Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Isolates Recovered in Nigerian Hospitals in 2016 to 2020.
The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.
Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades.
The study identifies multiple AMR genes, including bla OXA-23, bla NDM-1, armA, sul2, strA, strB, tet(B), aac(6')-Ian, and aac(3)-IIa, in multidrug-resistant ST25 Acinetobacter baumannii clades, highlighting their role in resistance to various antibiotics.
Aminoglycoside resistance genes in early members of the Acinetobacter baumannii ST78A (SMAL, Italian clone) reside in an IS26-bounded island in the chromosome.
The study identifies three aminoglycoside resistance genes (aadB, aphA1, and aac(6')-Ian) in the early ST78A isolate SMAL2002, along with sul2 and floR, located in an IS26-bounded chromosomal resistance island.
Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin's Lymphoma.
The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.
Phenotypic and genetic heterogeneity of Acinetobacter baumannii in the course of an animal chronic infection.
The study identified a conserved colistin resistance due to a pmrB mutation in Acinetobacter baumannii isolates during a 5-year urinary tract infection in an animal patient, despite the absence of antibiotic treatment.
Cloning and characterization of an aminoglycoside 6'-N-acetyltransferase gene from Citrobacter freundii which confers an altered resistance profile.
No comments yet. Be the first to comment!