Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside N-acetyltransferase AAC(6')-Il
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AAC(6')-Il | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 17 | TOBRAMYCIN, KANAMYCIN +6 | Proteus mirabilis +6 | South Korea, Egypt, Saudi Arabia, Singapore, Brazil, Netherlands|Kenya|United States|India|Tanzania, India, Spain, Western Balkans|Hungary, Europe | 1995, 2010, 2019, 2020, 2023, 2024, 2025 | HM750249.1 | ADO50680.1 |
| aac (6')-Il | Reslit | 1 | aminoglycosides | Providencia rettgeri | Colombia|USA | 2020 | VRPG00000000|VRPH00000000 | - |
| aac(6')-Il | ResFinder Database | 1 | TOBRAMYCIN, AMIKACIN | Klebsiella aerogenes | - | 1995 | U13880 | - |
Variability of the bla(IMP-15)-containing integrons, highly related to In95, on an endemic clone of Pseudomonas aeruginosa in Mexico.
Phenotypic and Genotypic Characterization of Acinetobacter spp. Panel Strains: A Cornerstone to Facilitate Antimicrobial Development.
The study characterized various AMR genes in Acinetobacter spp. including blaPER-1, blaTEM-1D, blaADC-31, blaOXA-82, aac(3')-Ia, aac(6')-Il, aph(3')-Ic, strAB, and others. Mutations in gyrA and parC were associated with fluoroquinolone resistance. Overexpression of efflux pumps like adeB and adeJ contributed to multidrug resistance.
First Genomic Characterization of bla(VIM-1) and mcr-9-Coharbouring Enterobacter hormaechei Isolated from Food of Animal Origin.
The study reports the first genomic characterization of a multidrug-resistant Enterobacter hormaechei isolate coharboring bla(VIM-1) and mcr-9 genes from food of animal origin. The isolate was resistant to carbapenems and other antibiotics, but susceptible to colistin. The bla(VIM-1) and mcr-9 genes were located on the same IncHI2 plasmid, along with other resistance genes.
Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.
Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Whole Genome Sequencing of Ceftolozane-Tazobactam and Ceftazidime-Avibactam Resistant Pseudomonas aeruginosa Isolated from a Blood Stream Infection Reveals VEB and Chromosomal Metallo-Beta Lactamases as Genetic Determinants: A Case Report.
The study identifies multiple AMR genes in a multidrug-resistant Pseudomonas aeruginosa strain, including beta-lactamases (blaVEB-9, blaOXA-10, blaOXA-50, blaPDC-11), aminoglycoside resistance genes (aph(3')-IIb, aac(6')-Il, ant(2'')-Ia), fluoroquinolone resistance gene (crpP), phenicol resistance gene (catB7), and tetracycline resistance gene (tet(A)).
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
Brevundimonas brasiliensis sp. nov.: a New Multidrug-Resistant Species Isolated from a Patient in Brazil.
The study characterizes Brevundimonas brasiliensis sp. nov., a novel species isolated from a neonatal intensive care unit, and identifies several antimicrobial resistance genes and mutations associated with resistance to β-lactams, aminoglycosides, fluoroquinolones, and colistin.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands.
The study identifies the NDM-1-producing Pseudomonas aeruginosa ST357 as an extensively drug-resistant strain with a unique resistome, highlighting the importance of tracking the origin of such isolates through genomic epidemiology.
Molecular Characterization of Pseudomonas aeruginosa Clinical Isolates Through Whole-Genome Sequencing: A Comprehensive Analysis of Biotypes, Sequence Types, and Antimicrobial and Virulence Genes.
The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa clinical isolates, including bla PDC, bla OXA, and bla VIM, which confer resistance to beta-lactams, as well as aac(6')-Il, aadA10, aph, and others that confer resistance to aminoglycosides. Additionally, genes like catB7, fosA, qnrVC1, and crpP were found to confer resistance to chloramphenicol, fosfomycin, quinolones, and fluoroquinolones, respectively.
Ceftazidime-avibactam plus aztreonam cocktail for the treatment of VIM-producing Pseudomonas aeruginosa infections: good enough to have another?
The study characterizes several AMR genes and mutations in VIM-producing P. aeruginosa isolates, including aac(6')-Ib3, aac(6')-Il, aac(6')-Ib-Hangzhou, aadA6, qnrVC1, VIM-2, VIM-1, blaCARB-4, and mutations in mexR and mexB. These genes and mutations contribute to resistance against various antibiotics such as aminoglycosides, quinolones, and beta-lactams.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model.
The study identified 15 AMR genes significantly more frequent in high-risk P. aeruginosa clones, including aminoglycoside, beta-lactam, phenicol, fluoroquinolone, trimethoprim, sulfonamide, and tetracycline resistance genes. These genes are often associated with mobile genetic elements, indicating a mobility-linked resistome in high-risk clones.
New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301.
New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301.
New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301.
New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301.
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