Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside N-acetyltransferase AAC(6')-Im
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AAC(6')-Im | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 19 | TOBRAMYCIN, KANAMYCIN +7 | [Clostridium] clostridioforme 90B1 +15 | Slovakia|Belgium|Czech Republic|France|Guatemala|Mexico|Philippines|Portugal|South Africa|Thailand|Turkey|United States|Venezuela, France, Norway|Japan|Bangladesh, Thailand, Australia|South Korea|USA|Belgium|Thailand|Germany|United States|Poland|Saudi Arabia|Israel|Kuwait|Spain|Serbia|Italy|Russia|China|Sweden, Chile, UK, Northwestern Transylvania, Romania, Europe, Norway|Sweden, Belgium | 1997, 2001, 2016, 2022, 2023, 2024, 2025 | AGYO01000035.1 | ENZ04101.1 |
| aac(6')-Im | ResFinder Database | 1 | TOBRAMYCIN, KANAMYCIN +3 | Escherichia coli, Citrobacter freundii | - | 2001 | AF337947, Z54241 | - |
Aminoglycoside Resistance Genes aph(2")-Ib and aac(6′)-Im Detected Together in Strains of both Escherichia coli and Enterococcus faecium.
The study identifies and characterizes the aminoglycoside resistance genes aph(2")-Ib and aac(6′)-Im, which confer resistance to various aminoglycoside antibiotics in both Escherichia coli and Enterococcus faecium.
Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium.
Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium.
Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium.
Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium., Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Im [corrected] associated with a sulI-type integron.
Whole-Genome Sequence of Multidrug-Resistant Campylobacter coli Strain COL B1-266, Isolated from the Colombian Poultry Chain.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Characterization and Fitness Cost of Tn7100, a Novel Integrative and Conjugative Element Conferring Multidrug Resistance in Haemophilus influenzae.
The study identifies Tn7100, a novel integrative and conjugative element carrying six resistance genes: blaTEM-1B, catA2, aac(6')-Im, aph(2'')-Ib, mef(E), and mel, which confer resistance to multiple antibiotics in Haemophilus influenzae.
Emergence and multi-lineages of carbapenemase-producing Acinetobacter baumannii-calcoaceticus complex from canine and feline origins.
The study identifies blaOXA-23 as a prevalent carbapenemase gene in carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex isolates from dogs and cats in Thailand. Additionally, several tetracycline and aminoglycoside resistance genes, including tet(B), tet(39), strA, strB, aac(3)-Ia, aac(3)-IIa, aac(6')-Im, aac(6')-Ib, ant(2'')-Ia, and aph(3')-VI, were detected.
Acinetobacter baumannii GC2 Sublineage Carrying the aac(6')-Im Amikacin, Netilmicin, and Tobramycin Resistance Gene Cassette.
The study identifies the aac(6')-Im gene as a key contributor to resistance against amikacin, netilmicin, and tobramycin in Acinetobacter baumannii GC2 sublineage. This gene is part of a resistance island and is frequently found alongside aacC1, which confers resistance to gentamicin.
Whole-genome sequencing reveals changes in genomic diversity and distinctive repertoires of T3SS and T6SS effector candidates in Chilean clinical Campylobacter strains.
The study identified a high genetic diversity among C. jejuni strains and detected mutations in the gyrA gene associated with fluoroquinolone resistance. No macrolide-resistance determinants were found, but tetracycline resistance genes (tetO) and beta-lactamase genes (blaOXA-61, blaOXA-193, blaOXA-450, blaOXA-605) were prevalent. Aminoglycoside resistance genes (aph(2")-If, aac(6')-Im, ant(6)-Ia) and multidrug efflux pump genes (cmeABC) were also detected in a multi-resistant strain.
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.
Distribution and expression of the aac(6')-Im (aacA16) aminoglycoside resistance gene.
The aac(6')-Im gene, which confers resistance to amikacin, netilmicin, and tobramycin, was found in multiple species including Pseudomonas putida and Enterobacter hormaechei. The gene was detected in both chromosomal and plasmid contexts, but its expression varied depending on the presence of the Pc promoter.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Unravelling the Persistence of the Rare Serovar Salmonella Mikawasima in a Hospital Setting: A Whole-Genome Sequencing Study.
The study identifies aminoglycoside resistance genes (aac(6')-Iaa, aac(6')-Im, aph(2")-Ib), beta-lactamase genes (bla TEM-1B, bla SHV-2), and the tetracycline resistance gene tet(D) in Salmonella Mikawasima isolates, highlighting multidrug resistance in hospital settings.
A computational study exploring echinoderm-derived compounds for inhibition of aminoglycoside acetyltransferases.
This study identified echinoderm-derived metabolites that show strong binding affinity and inhibitory potential against aminoglycoside acetyltransferases (AACs), including AAC(3)-Ib, AAC(6′)-Im, AAC(3)-Iva, and Aminoglycoside 2′-N-acetyltransferase. These compounds demonstrate promising activity in disrupting the function of these enzymes, which are critical for bacterial resistance to aminoglycoside antibiotics.
A computational study exploring echinoderm-derived compounds for inhibition of aminoglycoside acetyltransferases.
This study identified echinoderm-derived metabolites that show strong binding affinity and inhibitory potential against aminoglycoside acetyltransferases (AACs), including AAC(3)-Ib, AAC(6′)-Im, AAC(3)-Iva, and Aminoglycoside 2′-N-acetyltransferase. These compounds demonstrate promising activity in disrupting the function of these enzymes, which are critical for bacterial resistance to aminoglycoside antibiotics.
Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones.
The study identifies the expansion of multidrug-resistant Haemophilus influenzae clones with cefotaxime resistance, primarily due to mutations in the ftsI gene encoding penicillin-binding protein 3 (PBP3). These mutations lead to cross-resistance to multiple beta-lactam antibiotics.
Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Im [corrected] associated with a sulI-type integron.
The study characterizes the aac(6')-Im gene, which encodes an aminoglycoside 6'-N-acetyltransferase responsible for amikacin resistance. The gene was identified in clinical isolates and is part of a sulI-type integron.
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