Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside modifying enzyme
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aac(6')-lb-cr | Reslit | 14 | gentamicin, aminoglycosides +2 | Escherichia coli +12 | Netherlands, Nepal, Argentina, Malawi, Italy|Far East countries, Italy, Portugal, South West Nigeria, Dar es Salaam, Tanzania, Wales|Nigeria, Finland, Brazil, Europe | 2013, 2015, 2016, 2019, 2021, 2022, 2023, 2024, 2025 | NCBI:PRJNA245113|ERR349747|ERR349855|CDQG01000001|CDQG01000097|CDPE01000001|CDPE01000062|LN714331 | - |
| aac(6)-lb-cr | Reslit | 1 | gentamicin | Escherichia coli | South Africa | 2020 | - | - |
| aac(6′)-lb-cr | Reslit | 1 | gentamicin | Klebsiella pneumoniae | Vietnam | 2021 | PRJNA646358|NZ_CP020355|NZ_CP041642|NC_019984 | - |
Characteristics of cefotaxime-resistant Escherichia coli from wild birds in the Netherlands.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-3, bla CTX-M-14, bla CTX-M-32, and bla CMY-2, as well as plasmid-mediated quinolone resistance (PMQR) genes such as aac(6')-lb-cr, qnrB1, and qnrS1, in cefotaxime-resistant Escherichia coli isolates from wild birds in the Netherlands.
A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae.
The study identified two multidrug-resistant Klebsiella pneumoniae lineages responsible for hospital outbreaks, characterized by the presence of bla NDM-1, qnrB1, and other resistance genes, along with fluoroquinolone resistance mutations in gyrA and parC.
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.
The study shows that Acinetobacter baumannii A118 can acquire antibiotic resistance genes from other species through natural transformation, leading to increased resistance to various antibiotics such as meropenem, imipenem, and sulfamethoxazole.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Molecular Epidemiology of Antibiotic-Resistant Escherichia coli from Farm-To-Fork in Intensive Poultry Production in KwaZulu-Natal, South Africa.
The study identified the presence of bla CTX-M, sul1, tetA, and tetB genes in Escherichia coli isolates from various stages of the farm-to-fork continuum in intensive poultry production in South Africa.
Genomic Characterization of VIM and MCR Co-Producers: The First Two Clinical Cases, in Italy.
The study characterizes two clinical Enterobacter cloacae complex isolates co-producing VIM and MCR enzymes, identifying specific AMR genes and their resistance mechanisms.
Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit.
The study identifies multidrug-resistant Staphylococcus aureus ST188 and various Klebsiella pneumoniae strains with distinct resistance mechanisms, highlighting the role of colonization in causing infections in ICU patients.
KPC-3-Producing Klebsiella pneumoniae Sequence Type 392 from a Dog's Clinical Isolate in Portugal.
The study characterizes a KPC-3-producing Klebsiella pneumoniae ST392 isolate from a dog in Portugal, highlighting the presence of multiple AMR genes including blaKPC-3, aac(6')-lb-cr, tet(A), sul2, qnrB1, and OqxB/A, indicating multidrug resistance.
Occurrence of Pseudomonas lactis and Pseudomonas paralactis Amongst Non-Lactose-Fermenting Bacterial Isolates in Chickens and Their Antimicrobial Resistance Patterns.
The study identified Pseudomonas lactis and Pseudomonas paralactis in chicken fecal samples and characterized their antimicrobial resistance genes including aac(6')-lb-cr, blaCTX-M, blaSHV, and qnrS.
Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania.
The study identified high levels of fluoroquinolone resistance among ESBL-producing Enterobacterales isolates from children in Dar es Salaam, Tanzania, primarily due to plasmid-mediated quinolone resistance (PMQR) genes and chromosomal mutations.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
The study identified several AMR genes in Klebsiella pneumoniae ST1788, including blaSHV-232, blaCTX-M-15, blaCTX-M-266, blaOXA-1, blaTEM-1, aac(3')-lla, aac(6')-lb-cr, strA, strB, qnrB1, dfrA14, sul2, and blaOXA-48. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, trimethoprim, sulfamethoxazole, and carbapenems.
Prevalence, risk factors, and characterisation of extended-spectrum β-lactamase -producing Enterobacterales (ESBL-E) in horses entering an equine hospital and description of longitudinal excretion.
The study identified ESBL-E in 3% of horses admitted to an equine hospital, with specific beta-lactamase genes (blaCTX-M-1, blaCTX-M-14, blaTEM, blaSHV, blaOXA) and other resistance genes (aac(6')-lb-cr, catB3) contributing to multidrug resistance.
Impact of COVID-19 pandemic on antimicrobial resistance of Proteus mirabilis in a Brazilian hospital.
The study found a significant increase in the prevalence of resistance genes such as CTX-M-8, qnrD, and aac(6')-lb-cr in Proteus mirabilis isolates during the COVID-19 pandemic compared to the pre-pandemic period.
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis.
The study evaluated the diagnostic performance of PISTE™ technology, an NGS-based workflow for detecting bloodstream pathogens and predicting antimicrobial resistance. It showed high accuracy in identifying pathogens and predicting resistance genes, including beta-lactamases, carbapenemases, aminoglycoside modifying enzymes, tetracycline efflux pumps, and quinolone resistance proteins.
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