aac(6)_serra

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aminoglycoside modifying enzyme

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aac(6)_serra

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: genome screening
Drug Classes: amikacin, gentamicin, tobramycin
Organisms: Serratia marcescens, Serratia ureilytica, Serratia sarumanii, Serratia bockelmannii, Serratia nevei
Geographic Location: China
Papers: 1
Databases: Reslit

Papers1

Genomic diversity, antimicrobial resistance and dissemination of Serratia marcescens complex in patients admitted to ICUs.

PMID 41181329 · 2025

The study identified multiple AMR genes in Serratia marcescens complex isolates, including beta-lactamases (bla_SRT, bla_CTX-M-14, bla_CTX-M-3, bla_CTX-M-15), carbapenemases (bla_KPC-2, bla_NDM-5), and aminoglycoside-modifying enzymes (aac(6')_Serra). These genes were associated with resistance to various antibiotics, including cephalosporins, carbapenems, and aminoglycosides.

Gene Information

Gene Name: aac(6)_serra
Allele: aac(6')_Serra
Encodes: aminoglycoside modifying enzyme
Source Database: Reslit
Confers Resistance To: amikacingentamicintobramycin
Organisms Tested In: • Serratia marcescens
• Serratia ureilytica
• Serratia sarumanii
• Serratia bockelmannii
• Serratia nevei
Geographic Location: China
Validation Method: genome screening
Sequence Accession: PRJNA1191627

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aac(6)_serra

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aac(6)_serra

Gene Information