aac(6)iaa

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aminoglycoside acetyltransferase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to aac(6)iaa

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Validation StatusCandidate

Overview

Mechanism: plasmid-mediated
Validation Method: whole genome sequencing and plasmid characterization
Drug Classes: aminoglycosides
Organisms: Salmonella enterica serovar Typhi
Geographic Location: India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo
Papers: 1
Databases: Reslit

Papers1

Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.

PMID 33965548 · 2021

The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.

Gene Information

Gene Name: aac(6)iaa
Allele: aac(6')Iaa
Encodes: aminoglycoside acetyltransferase
Source Database: Reslit
Mechanism: plasmid-mediated
Confers Resistance To: aminoglycosides
Organisms Tested In: • Salmonella enterica serovar Typhi
Geographic Location: India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo
Validation Method: whole genome sequencing and plasmid characterization
Sequence Accession: ERR1862943|ERR578472|ERR578473|ERR2093236|ERR2093334|ERR3527963|ERR3527964|MQUM00000000|MQUL00000000|CP052767|CP052768|CP053702|CP053703

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aac(6)iaa

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aac(6)iaa

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