Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase AacA43
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AacA43 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | KANAMYCIN, TOBRAMYCIN +7 | Acinetobacter baumannii TG02011 +5 | Australia | 2011, 2012, 2022, 2023 | ASES01000046.1 | AEA07977.1 |
| aacA43 | ResFinder DatabaseReslit | 2 | TOBRAMYCIN, AMIKACIN +4 | Klebsiella pneumoniae | Japan | 2011, 2018 | HQ247816 | - |
A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.
A novel aminoglycoside resistance gene, aacA43, was identified in a class 1 integron. It confers resistance to kanamycin and tobramycin but not to gentamicin.
A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.
A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.
A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.
A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.
Two novel class I integron arrays containing IMP-18 metallo-β-lactamase gene in Pseudomonas aeruginosa clinical isolates from Puerto Rico.
Complete Genome Sequence of bla (IMP-6)-Positive Metakosakonia sp. MRY16-398 Isolate From the Ascites of a Diverticulitis Patient.
The study identifies the blaIMP-6 gene, along with aacA4'-3, aadA2, and tet(A), as responsible for carbapenem and aminoglycoside resistance in the novel Metakosakonia sp. strain MRY16-398.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Fecal antibiotic resistance genes were transferred through the distribution of soil-lettuce-snail food chain.
The study identified several antibiotic resistance genes (ARGs) such as aacA43, mel_1, vanRB, tetM, tnpA-2, sul1, sul2, ermF, and vatB that were transferred through the soil-lettuce-snail food chain. These genes conferred resistance to various antibiotics including aminoglycosides, tetracyclines, sulfonamides, MLSB, and vancomycin.
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