Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside acetyltransferase
Overview
Transcriptome Profiling of Antimicrobial Resistance in Pseudomonas aeruginosa.
The study identifies multiple AMR genes and mutations in Pseudomonas aeruginosa, including aadA1, aadA6, aacA4, aacA7, aacA5, blaOXA-2, blaOXA-4, blaVIM-1, blaVIM-2, blaGIM-2, blaIMP-1, blaIMP-7, blaPER-1, blaCTX-M-3, ampC, gyrA (T83I), and parC (S87L/W), which are associated with resistance to various antibiotics such as tobramycin, ceftazidime, meropenem, and ciprofloxacin.
Distribution and Molecular Characterization of Resistance Gene Cassettes Containing Class 1 Integrons in Multi-Drug Resistant (MDR) Clinical Isolates of Pseudomonas aeruginosa.
The study identified several resistance gene cassettes within class 1 integrons in multidrug-resistant Pseudomonas aeruginosa isolates, including aadB, aacA4, blaOXA-10, aacA5, cmlA5, and VIM-1, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, and chloramphenicol.
Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals.
The study identified several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica serovar Kentucky ST198 isolates from Spanish hospitals. Key findings include the presence of blaTEM-1B, aacA5, aadA7, sul1, tet(A), catA1, and aac(6′)-Ib genes, along with mutations in gyrA (Ser83Phe) and parC (Thr57Ser, Ser80Ile).
The expression of aminoglycoside resistance genes in integron cassettes is not controlled by riboswitches.
The study demonstrates that the aacA5 gene, which encodes an aminoglycoside N-acetyltransferase, is not induced by aminoglycosides in its native genetic context, refuting the existence of an aminoglycoside-sensing riboswitch in integron cassettes.
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