The study characterizes the integrons In4 and In2 found in transposons Tn1696 and Tn21, identifying specific genes such as aadA2, aacC1, and cmlA1 that confer resistance to streptomycin, spectinomycin, gentamicin, and chloramphenicol.

The study identifies several AMR genes and mutations in the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06, including bla oxa-23, armA, and various efflux pumps, contributing to resistance against multiple antibiotics.

The study characterizes multiple AMR genes and mutations in Acinetobacter spp., including OXA-type carbapenemases, aminoglycoside-modifying enzymes, and fluoroquinolone resistance genes, highlighting the increasing challenge of multidrug-resistant Acinetobacter infections.

The study shows that deletion of TnAbaR23 in Acinetobacter baumannii leads to increased susceptibility to sulfamethoxazole and gentamicin, highlighting the role of this transposon in multidrug resistance.

The study identifies multiple efflux pumps, porins, and β-lactamases contributing to multidrug resistance in Acinetobacter baumannii, including adeB, adeJ, tetB, tetA(39), and aacC1, aphA1, aadB genes, along with mutations in gyrA and parC.

The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from military treatment facilities, including bla OXA-51-like, bla OXA-23, bla GES-11, aac(6')-Ib, aacC1, aadB, aphA6, and others, highlighting the complex resistome of these isolates.

The study identified fluoroquinolone-resistant Escherichia coli isolates with mutations in gyrA and parC genes, as well as aac(6')-Ib-cr, aacC1, aadA1, aadB, and aacC2 genes associated with gentamicin resistance.

The study found that aacC1, aphA6, aadA1, and aadB genes are prevalent in Acinetobacter baumannii isolates in Tabriz, Iran, contributing to aminoglycoside resistance.

The study identified several AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (bla SHV, bla TEM, bla CTX-M), aminoglycoside resistance genes (aacC1, aacC4, aadA1, strB), carbapenemase (bla KPC-2), and quinolone resistance gene (qnrB). Additionally, a gyrA mutation (S83L) was found to confer quinolone resistance.

The study identifies several AMR genes in the A320 strain of Acinetobacter baumannii, including blaTEM, aacC1, aadA1, sul1, catA1, and aphA1b, which confer resistance to various antibiotics.

The study identified blaOXA-23 and blaAmpC genes contributing to carbapenem and extended-spectrum cephalosporin resistance, and mutations in pmrA, pmrB, lpxD, lpxC, and lpsB genes linked to polymyxin resistance in A. baumannii AC30.

The study identified various aminoglycoside resistance genes and novel transposons, including Tn6279, ΔTn6279, and Tn1548-like structures, contributing to the resistance of carbapenem-resistant Acinetobacter baumannii isolates.

The study describes the development of a cassette containing the thiostrepton resistance gene tsr and the gentamicin resistance gene aacC1, which can be used as selection markers in mycobacteria.

The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.

The study identified various AMR genes and mutations in extensively drug-resistant Pseudomonas aeruginosa isolates from Spain, including beta-lactamases, aminoglycoside-modifying enzymes, and mutations in genes such as ampC, oprD, gyrA, parC, mexZ, and glpT, which contribute to resistance against multiple antibiotics.

The study describes the development of new shuttle vectors, pVRL1 and pVRL2, for gene cloning and expression in multidrug-resistant Acinetobacter species. These vectors incorporate antibiotic resistance markers such as aacC1 for gentamicin and ble for zeocin, enabling effective selection in both E. coli and Acinetobacter strains.

The study demonstrates the successful detection of antimicrobial resistance-associated proteins using TiO2-facilitated MALDI-TOF MS without sample pre-treatment. Specific resistance proteins such as blaTEM-1, aacC1, cat, and ampC were identified in various bacterial strains.

The study identified various AMR genes in clade F strains of Acinetobacter baumannii, including blaOXA-23, aadB, aadA2, aphA6, aacC1, aadA1, and armA, which confer resistance to multiple antibiotics.

The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.

The study demonstrates that the aacC1 gene encoding the N-acetyltransferase AAC(3)-I provides gentamicin resistance in Phytophthora palmivora and Phytophthora infestans, enabling its use as a selectable marker for genetic transformation.

The study identifies several mutations in Shewanella oneidensis MR-1 that contribute to increased plasmid persistence in biofilms, including insertions of the transposon Tn6374 in plasmid transfer genes and chromosomal mutations affecting various cellular functions.

The study shows that removing the AbaR resistance island from Acinetobacter baumannii restores antibiotic susceptibility and increases natural transformability. Several AMR genes within AbaR were identified, including aadB, aacC1, aphA1b, aacA, aadA1, strA, strB, blaVEB-1, blaOXA-10, sul1, dhfrI, dhfrX, tetA(A), tetA(G), cmlA1, cmlA5, cmlA9, catA1, arr-2, and sup.

The study identified several aminoglycoside resistance genes (aadA1, aadB, aphA6, aacC1) and carbapenemase genes (blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, blaOXA-58-like) in Acinetobacter baumannii isolates from Ahvaz, Iran, highlighting the high prevalence of multidrug-resistant strains.

The study identifies multiple antibiotic resistance genes, including catA1, tetA(A), sul1, aacC1, aadA1, aphA6, and oxa23, in two carbapenem-resistant Acinetobacter baumannii strains, ABH008 and ABS200, highlighting their extensive drug resistance.

The study identifies multiple carbapenemase genes, including blaOXA-23 and blaOXA-207, as well as various resistance islands harboring genes such as aacA4, catB8, and armA, contributing to the multidrug resistance of CR Ab isolates in U.S. hospitals.

The study highlights the effectiveness of molecular analysis (MA) combined with molecular antibiogram in improving the diagnosis and targeted therapy of infective endocarditis (IE), particularly in blood culture-negative cases. It shows that molecular antibiogram has high concordance with traditional antimicrobial susceptibility testing (AST) and can identify resistance genes such as aadA1, aacC1, AAC(6)-Ib-cr, QnrS, CTX-M-1 Group, SHV, KPC, and tetA.

The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.

The study demonstrates the use of a CRISPR-Cas9 delivery tool, pKJK5::csg, to remove AMR plasmids, specifically targeting the gentamicin resistance gene aacC1.

The study characterizes the resistance genes aacC1, aphA, and aadA, which confer resistance to gentamicin, kanamycin, and streptomycin, respectively, in Escherichia coli MG1655. These genes were experimentally validated through chromosomal tagging and electroporation techniques.

The study identified several AMR genes within AbGRIs in GC2 A. baumannii isolates from COVID-19 patients, including strA, strB, tetA(B), tetR(B), sul2, oxa23, aacC1, aadA1, blaTEM, armA, aacA4, aphA1b, and sul1, which confer resistance to various antibiotics such as aminoglycosides, tetracyclines, sulfonamides, carbapenems, and beta-lactams.

The study identifies numerous antibiotic resistance genes (ARGs) that are transferred between plasmids, particularly beta-lactamases (bla TEM-1, bla NDM-4, bla KPC-2, bla SHV-1), aminoglycoside resistance gene aacC1, and colistin resistance gene mcr-1. These genes are shown to transfer between compatible plasmids in clinical pathogens, accelerating the spread of antibiotic resistance.

The study characterizes the carbapenem-resistant Acinetobacter baumannii isolate BAL062, identifying resistance genes such as oxa23, ampC, strA-strB, tet(B), sul1, aadA1, and aacC1. It also reveals that BAL062 has lost certain resistance genes, resulting in susceptibility to amikacin, tobramycin, and kanamycin.

The study identifies aacC1 as a gene conferring resistance to both gentamicin and G418 in Marchantia polymorpha, demonstrating cross-resistance. This finding expands the utility of G418 as a selection agent and highlights the potential for strategic antibiotic use in plant transformation.

The study presents a framework to predict no-effect concentrations for antibiotic resistance selection in the environment by integrating minimum inhibitory concentration (MIC) data with resistance-related fitness costs. It identifies various AMR genes and their resistance profiles through competition experiments.

The study identified the armA, aac(3'-IIa, aacC1, and rmtB genes as the primary aminoglycoside resistance genes in non-lactose fermenting gram-negative rods isolated from neurosurgical patients. These genes conferred resistance to gentamicin and amikacin.

The study describes the development of antibiotic-resistance and promoter-probe cassettes containing the aacC1 gene from transposon Tn1696, which confers resistance to gentamicin in various bacteria, along with a promoterless lacZ gene for transcriptional activity monitoring.

The study identifies three class 1 integrons (In-t1, In-t2, and In-t3) carrying various antibiotic resistance gene cassettes in Salmonella enterica serotype Typhimurium, highlighting the role of mobile genetic elements in the spread of multidrug resistance.