aacc2a

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modification of aminoglycoside antibiotics

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Validation StatusCandidate

Overview

Mechanism: modification of aminoglycoside antibiotics
Validation Method: whole-genome sequencing and phenotypic testing
Drug Classes: aminoglycosides
Organisms: Enterobacter cloacae
Geographic Location: UK
Papers: 1
Databases: Reslit

Papers1

Whole-genome sequencing enhances existing pathogen and antimicrobial-resistance surveillance schemes within a neonatal unit.

PMID 35696727 · 2022

The study identified the ESBL-encoding gene blaCTX-M-15 in various Gram-negative isolates, highlighting horizontal gene transfer of resistance genes within the neonatal unit. Additionally, the aminoglycoside-resistance gene aacC2a was found in Enterobacter cloacae isolates.

Gene Information

Gene Name: aacc2a
Allele: aacC2a
Encodes: modification of aminoglycoside antibiotics
Source Database: Reslit
Mechanism: modification of aminoglycoside antibiotics
Confers Resistance To: aminoglycosides
Organisms Tested In: • Enterobacter cloacae
Geographic Location: UK
Validation Method: whole-genome sequencing and phenotypic testing
Sequence Accession: PRJNA778615

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aacc2a

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aacc2a

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