Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside acetyltransferase
Overview
The kinetic mechanism of AAC(3)-IV aminoglycoside acetyltransferase from Escherichia coli.
The study characterizes the aminoglycoside acetyltransferase AAC(3)-IV from Escherichia coli, which confers resistance to a broad range of aminoglycosides, including apramycin.
Molecular Epidemiology of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in the Calgary Health Region: Emergence of VIM-2-Producing Isolates.
The study identifies VIM-2 and IMP-7 metallo-β-lactamase genes along with aacC1, aacA4, and aacC4 gene cassettes in Pseudomonas aeruginosa isolates, highlighting the molecular epidemiology of carbapenem-resistant strains in the Calgary Health Region.
Molecular characterization of multidrug-resistant Klebsiella pneumoniae isolates.
The study identified several AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (bla SHV, bla TEM, bla CTX-M), aminoglycoside resistance genes (aacC1, aacC4, aadA1, strB), carbapenemase (bla KPC-2), and quinolone resistance gene (qnrB). Additionally, a gyrA mutation (S83L) was found to confer quinolone resistance.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Antimicrobial Resistance, Virulence Profiles, and Public Health Significance of Enterococcus faecalis Isolated from Clinical Mastitis of Cattle in Bangladesh.
The study identified tetracycline resistance genes tetK, tetL, and tetM, as well as aminoglycoside resistance genes aacC2, aacC4, and aph(3'')-IIIa, and the vancomycin resistance gene vanB in Enterococcus faecalis isolates from bovine clinical mastitis in Bangladesh.
Phenotypic and Genotypic Characteristics of Antimicrobial Resistance in Citrobacter freundii Isolated from Domestic Ducks (Anas platyrhynchos domesticus) in Bangladesh.
The study identified multiple AMR genes in Citrobacter freundii isolates from domestic ducks in Bangladesh, including beta-lactamases (bla TEM-1, bla CMY-2, bla CMY-9, bla CTX-M-14), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tetA, tetB), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), and an aminoglycoside resistance gene (aacC4).
Growth in a biofilm promotes conjugation of a bla (NDM-1)-bearing plasmid between Klebsiella pneumoniae strains.
The study identifies the bla NDM-1 gene on the plasmid pCPE16_3 as a key contributor to carbapenem resistance in Klebsiella pneumoniae, demonstrating that biofilm growth enhances the conjugative transfer of this plasmid.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
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