Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AadA1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 402 | STREPTOMYCIN, streptomycin +4 | Vibrio cholerae O1 +153 | United States, Italy, India, Laos, Japan, Denmark, France, Georgia, Bolivia, Africa|Europe|Asia|America, Argentina, Ghana, Singapore|Colombia|Guyana|Brazil|Manaos, China, Europe|United States|Australia, Switzerland, Australia, Tunisia, Europe, Global, US, Germany, Thailand, Iran, China|Beijing, China, Nepal, South West London, UK, Poland, Lower Saxony|Germany, Okinawa Prefecture, Japan, Japan|Thailand|Canada|France|Spain|South Korea|United Kingdom|Croatia|Vietnam|global, Netherlands, Malaysia, Sweden|Australia|Japan|France|United Arab Emirates|India|South Africa|Netherlands|Canada|China, Europe|Italy, Germany|France|Netherlands|Belgium, San Francisco|Seattle|Minnesota|Minneapolis|Sacramento|Dallas|Jackson, Delhi, India, Europe|Switzerland|Canada, Ethiopia, Europe|seafood, Vietnam, Peru, Pakistan, UK|Latin America, Chile, Scotland, Czechia|Czech Republic, Bangladesh|Sweden, South Korea, Montreal, Canada, Nigeria, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, Michigan, USA, Senegal, Cleveland, OH|Baltimore, MD, Brazil, South Africa, Denmark|Japan, Maputo, Mozambique, Texas, Greece, Bangladesh, Belgium, Southern China, Canada, Tuscany, USA|Peru|Egypt|Cambodia|Kenya, Brazilian Amazon, Thailand|Nepal, Arizona, USA, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, Sikkim|India, Sweden, Pacific region|Hawaii, Egypt, Kenya, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Guizhou, China, North America|Asia|Europe|Australia|South America, Spain, Vietnam|Southeast Asia, Romania|Spain, sub-Saharan Africa|Burkina Faso|Ghana|Guinea-Bissau|Kenya|Senegal, Brasília, Brazil, United Kingdom|England|Australia, Mexico|Mexico City, Europe|Poland, Cambodia, England|Wales, Norway, Europe|Greece, England, North-Western Mexico, Europe|EU|China|Portugal|Germany, Hubei, China|China, Europe|Portugal, North America|Asia|Europe|Middle East|Africa, Shandong Province|China, China|France|Australia|Germany|USA|Netherlands|Japan|Cambodia|Thailand|Vietnam|India|Pakistan|Chile|Czech Republic|Colombia|China (bigeye tuna), Spain|Peru, Cameroon|South Africa, Nepal|Kathmandu, Nepal, Southern Europe, New Zealand, Alberta, Canada, North Sea|Baltic Sea, South America|Chile, Ontario, Canada, Belgium|The Netherlands|Europe, United Kingdom|Thailand|UK, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, United Kingdom, Mexico|Japan|China|Israel|New Zealand|United States, Pakistan|Karachi, Pakistan, New Hampshire, USA|global, Mexico, Oman, Central Greece, Uganda, Colombia, Central Adriatic|Central Adriatic Sea, Tennessee, USA|East Tennessee, Lebanon, North Carolina, Southeast Brazil, Portugal, Brazil|Europe|United Kingdom|United States, Bangkok, Thailand, UK, Taiwan, Thailand|Pig|Pork, Fiji, Madagascar, Netherlands|Kenya|United States|India|Tanzania, Anhui province, China, Ecuador, Portugal|various regions, Europe|South America|Asia|North Africa, Latin America, Somali region, Ethiopia|Somali Region, Ethiopia, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Europe|Africa|North America|South America|Asia|Oceania, Croatia, Finland, Northern Italy, Kano, Nigeria|Nigeria, Western Balkans|Hungary, Mansoura, Egypt, China|Lebanon|United States|Poland|France, North Carolina, USA, Vermont, Paraguay|Northern Spain, Europe|Croatia, Atlanta, Mekong Delta, Vietnam, Shenzhen, China, Australia|France|Bangladesh|United States, Harare, Zimbabwe, Upper Egypt|Egypt, Europe|Turkey, Africa, Iraq | 1985, 1992, 1998, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AB107663.1 | BAC84997.1 |
| aadA | Card Database | 1 | - | Escherichia coli | - | - | AF550679.1 | AAO49597.1 |
| aadA1 | ResFinder Database | 1 | STREPTOMYCIN, SPECTINOMYCIN | Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae | - | 2009 | FJ591054, JQ414041, JQ480156, JX185132 | - |
| ΔaadA1 | Reslit | 1 | streptomycin, spectinomycin | Escherichia coli | Europe | 2012 | FJ914220 | - |
| aad(A) | Reslit | 1 | streptomycin | Escherichia coli | Canada | 2013 | - | - |
| aad A | Reslit | 5 | streptomycin, aminoglycosides | Escherichia coli +4 | India, South Africa, Botswana, Egypt | 2018, 2021, 2022, 2025 | KX300038–KX300086|KY432753|KU573047–KU573052|KY924468–KY924470 | - |
| aad(A1) | Reslit | 1 | streptomycin | Escherichia coli | Egypt | 2018 | - | - |
| aad A1 | Reslit | 11 | streptomycin, aminoglycosides | Shigella dysenteriae +11 | India, Colombia|USA, Western Cape, South Africa, Europe, Vietnam, Egypt, Ontario, Canada, United States, Northern Spain, Guangdong, China | 2019, 2020, 2021, 2022, 2023, 2024, 2025 | MDDI00000000|MDDH00000000|MDGW00000000|MDJL00000000|MIIV00000000|MINP00000000|MINQ00000000|MINR00000000|MINU00000000|MDJJ00000000|MECX00000000|MDJI00000000|MECW00000000|MIIX00000000|MIIY00000000|MINS00000000|MINT00000000|MDJK00000000|MECT00000000|MINV00000000|NGWI00000000|NGWH00000000|NGWG00000000|NGWF00000000|NGWE00000000|NGWD00000000|NGWC00000000|NGWB00000000|NGWA00000000|NGVZ00000000|NGVY00000000|NGVX00000000|NGVW00000000|NMYB00000000|NMYA00000000|NMXZ00000000|NMXY00000000|NMXX00000000|NMXW00000000|NMXV00000000|NMXU00000000|NMXT00000000|NMXS00000000|NMXR00000000|NMXQ00000000|NMXP00000000|NMXO00000000|PDYE00000000|PDYD00000000|PDYC00000000|PDYB00000000|PDYA00000000|PDXZ00000000|PDXY00000000|PDXX00000000|PDXW00000000|PDXV00000000|PDXU00000000|PDXT00000000|PDXS00000000 | - |
| aadA1-dfrA1 | Reslit | 2 | streptomycin | Escherichia coli | Italy, Iran | 2020, 2023 | NCBI BioProject PRJNA661235 | - |
| aadA1-pm | Reslit | 2 | aminoglycosides | Acinetobacter baumannii | Alexandria, Egypt | 2023 | PRJNA856145 | - |
| aad-A | Reslit | 1 | streptomycin | Avibacterium paragallinarum | Guangdong Province, China | 2024 | PRJNA1037493 | - |
| AadA-1 | Reslit | 1 | aminoglycosides | Escherichia coli | Europe | 2025 | - | - |
| aadA-1 | Reslit | 1 | streptomycin | Escherichia coli | Tunisia | 2025 | - | - |
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.
Characterization and chromosomal mapping of antimicrobial resistance genes in Salmonella enterica serotype typhimurium.
Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes.
The study characterizes In53, a unique class 1 integron in Escherichia coli that carries multiple antibiotic resistance gene cassettes, including aadB, arr-2, cmlA5, qacI, aacA1b/orfG, oxa10, and aadA1, each contributing to resistance against various antibiotics.
Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes.
Identification and characterization of integron-mediated antibiotic resistance among Shiga toxin-producing Escherichia coli isolates.
The study identifies class 1 integrons in Shiga toxin-producing Escherichia coli (STEC) isolates, including the aadA, aadA1, aadA2, and dfrXII genes, which confer resistance to streptomycin, spectinomycin, and trimethoprim.
Expanding Drug Resistance through Integron Acquisition by IncFI Plasmids of Salmonella enterica Typhimurium.
The study identifies multiple antibiotic resistance genes, including aadB, catB3, aadA1, and oxa1, carried by IncFI plasmids in Salmonella enterica Typhimurium, highlighting the role of integrons in expanding drug resistance.
Family of Class 1 Integrons Related to In4 from Tn1696.
The study characterizes the class 1 integrons In28 and In1, identifying the genes blaP1, cmlA1, and aadA1 as conferring resistance to carbenicillin, ampicillin, chloramphenicol, streptomycin, and spectinomycin.
Characterization and movement of the class 1 integron known as Tn2521 and Tn1405.
The study characterizes the class 1 integron In33 (Tn2521) and identifies the genes blaP1a and aadA1, which confer resistance to carbenicillin, ampicillin, streptomycin, and spectinomycin.
Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1.
The study characterizes the multiresistance plasmid pJHCMW1 from Klebsiella pneumoniae, identifying four antibiotic resistance genes: aac(6')-Ib, aadA1, blaOXA-9, and blaTEM-1.
Class I integrons and SXT elements in El Tor strains isolated before and after 1992 Vibrio cholerae O139 outbreak, Calcutta, India.
The study identified the aadA1 gene cassette within class I integrons in pre-O139 Vibrio cholerae O1 El Tor strains, which confers resistance to aminoglycosides, streptomycin, and spectinomycin. The SXT element was prevalent in post-O139 strains and contributed to resistance against streptomycin and trimethoprim.
Antimicrobial resistance and genetic diversity of Shigella sonnei isolates from western Ireland, an area of low incidence of infection.
The integron In1 in plasmid R46 includes two copies of the oxa2 gene cassette.
The integron In1 in plasmid R46 includes two copies of the oxa2 gene cassette.
Antibiotic Resistance Conferred by a Class I Integron and SXT Constin in Vibrio cholerae O1 Strains Isolated in Laos.
The study identifies the presence of a class I integron with the aadA1 gene cassette and an SXT constin in Vibrio cholerae O1 strains from Laos, which confer resistance to multiple antibiotics including streptomycin, chloramphenicol, tetracycline, and sulfamethoxazole.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.
Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.
Diversity of aminoglycoside-resistance genes and their association with class 1 integrons among strains of pan-European Acinetobacter baumannii clones.
Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
The study identifies a novel trimethoprim resistance gene, dfrA23, on a Salmonella enterica serovar Typhimurium virulence plasmid, along with other resistance genes such as aadB, blaOXA-30, and aadA1.
Characterization of class 1 integrons-mediated antibiotic resistance among calf pathogenic Escherichia coli.
Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.
The study identifies high-level fluoroquinolone-resistant Salmonella enterica serovar Typhimurium isolates with mutations in gyrA (S83F, D87N/G) and parC (S80R), along with resistance genes blaOXA-30, aadA1, dhfr12, aadA2, aac3, catA, and tetRA.
Incidence of class 1 integrons in multiple antibiotic-resistant Gram-negative copiotrophic bacteria from the River Torsa in India
The study identified various gene cassettes within class 1 integrons in multiple antibiotic-resistant Gram-negative bacteria from the River Torsa in India, including dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, aac(6')-Ib, aadA1, aadA6, and a novel ORF with homology to dfrA1.
Class 1 integrons and tetracycline resistance genes in alcaligenes, arthrobacter, and Pseudomonas spp. isolated from pigsties and manured soil.
The study identifies several tetracycline resistance genes (tet(A), tet(C), tet(33)) and gene cassettes (aadA1, aadA2, aadA9, aadA11, dfrA1, dfrB2a) associated with class 1 integrons in various bacterial species isolated from pigsties and manured soil.
Comparative genomics of multidrug resistance in Acinetobacter baumannii.
The study identifies numerous resistance genes in the multidrug-resistant Acinetobacter baumannii strain AYE, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of its resistance mechanisms.
Large conjugative plasmids from clinical strains of Salmonella enterica serovar virchow contain a class 2 integron in addition to class 1 integrons and several non-integron-associated drug resistance determinants.
Antibiotic resistance, integrons and Salmonella genomic island 1 among non-typhoidal Salmonella serovars in The Netherlands.
Antibiotic resistance, integrons and Salmonella genomic island 1 among non-typhoidal Salmonella serovars in The Netherlands.
Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center.
The study identified multiple antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates, including bla ADC, bla OXA-69-like, bla OXA-23-like, bla OXA-58-like, bla TEM, bla PER, aacC1, aacC2, aadA1, aadB, and aphA6, which confer resistance to various antibiotics such as ceftazidime, cefepime, imipenem, meropenem, ampicillin, ampicillin-sulbactam, gentamicin, tobramycin, streptomycin, spectinomycin, amikacin, kanamycin, and neomycin.
Impact of antimicrobial usage on antimicrobial resistance in commensal Escherichia coli strains colonizing broiler chickens.
The study identified the aadA1 gene as a major contributor to streptomycin resistance in commensal E. coli strains from broiler chickens, highlighting the impact of antimicrobial usage on resistance development.
Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure.
The study identified various acquired antibiotic resistance genes in commensal E. coli isolates from a remote community with minimal antibiotic exposure, including blaTEM, catI, cmlA6, tet(A), tet(B), dfrA1, dfrA7, dfrA8, dfrA17, sul1, sul2, aphA1, aadA1, aadA2, aadA5, aadB, and sat-1. These genes were found to be similar to those seen in antibiotic-exposed settings, indicating the dissemination of resistant bacteria and resistance genes from such environments.
High genetic stability of integrons in clinical isolates of Shigella spp. of worldwide origin.
The study identifies blaOXA-30 and aadA1 as key genes contributing to antibiotic resistance in Shigella spp., highlighting the role of integrons in multidrug resistance.
Comparative analysis of IncHI2 plasmids carrying blaCTX-M-2 or blaCTX-M-9 from Escherichia coli and Salmonella enterica strains isolated from poultry and humans.
Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant.
Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant.
Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements.
The study characterizes the multiresistance plasmid pMET1 from Klebsiella pneumoniae, identifying several AMR genes including bla TEM-1, aac(6')-Ib, aadA1, and bla OXA-9, which confer resistance to beta-lactams and aminoglycosides.
Characterization of antimicrobial resistance and class 1 integrons in Enterobacteriaceae isolated from Mediterranean herring gulls (Larus cachinnans).
Characterization of antimicrobial resistance and class 1 integrons in Enterobacteriaceae isolated from Mediterranean herring gulls (Larus cachinnans).
Vibrio cholerae O1 from Accra, Ghana carrying a class 2 integron and the SXT element.
The study identifies the presence of class 2 integrons carrying dfrA1, sat, and aadA1 cassettes in Vibrio cholerae O1 isolates from Accra, Ghana, which confer resistance to trimethoprim and streptomycin.
Occurrence of antibiotic resistance and class 1, 2 and 3 integrons in Escherichia coli isolated from a densely populated estuary (Seine, France)., New integron gene arrays from multiresistant clinical isolates of members of the Enterobacteriaceae and Pseudomonas aeruginosa from hospitals in Malaysia., Antibiotic-resistant Escherichia coli in karstic systems: a biological indicator of the origin of fecal contamination?, Detection of VIM-34, a novel VIM-1 variant identified in the intercontinental ST15 Klebsiella pneumoniae clone.
Molecular Diagnostic Technologies in Clinical Microbiology
The paper describes a DNA microarray for genotyping antibiotic resistance in Pseudomonas aeruginosa, identifying several resistance genes and mutations associated with various antibiotics.
Mechanism of drug resistance in a clinical isolate of Vibrio fluvialis: involvement of multiple plasmids and integrons.
Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant.
Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant.
Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant.
High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.
The study identified a high prevalence of multidrug-tolerant bacteria and various antimicrobial resistance genes in ornamental fish and their carriage water, highlighting the potential risk of resistance gene spread through the aquatic environment.
Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.
The study identifies several antibiotic resistance genes in the enteroaggregative E. coli strain 042, including cat, tetA, aadA1, suI, and emrE, which contribute to resistance against chloramphenicol, tetracycline, streptomycin, spectinomycin, sulfonamide, and ethidium bromide.
Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
Identification and molecular characterization of antimicrobial-resistant shiga toxin-producing Escherichia coli isolated from retail meat products.
The study identified class 1 integrons carrying aadA1 and dfrA1 gene cassettes in Shiga toxin-producing Escherichia coli (STEC) isolates from retail meat products, contributing to multidrug resistance.
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
The study characterizes various AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I, identifying multiple AMR genes such as blaTEM-1, aacC1, aadA1, aacA4, dfrA1, catA1, sul1, and tetA, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Acinetobacter baumannii isolates from pets and horses in Switzerland: molecular characterization and clinical data.
The study identified several AMR genes and mutations in Acinetobacter baumannii isolates from pets and horses in Switzerland, including blaOXA-66, blaADC-25, blaTEM-1, aacC2, aadA1, aacC1, IS1133, ISAb1, and mutations in gyrA and parC genes associated with resistance to carbapenems, cephalosporins, piperacillin/tazobactam, gentamicin, and ciprofloxacin.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China.
The study identifies several AMR genes and mutations in the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06, including bla oxa-23, armA, and various efflux pumps, contributing to resistance against multiple antibiotics.
QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India.
The study identified QRDR mutations in gyrA and parC, as well as the aac(6')-Ib-cr gene, class 1 and class 2 integrons, and various resistance genes including blaTEM-1, catA1, dfrA1, dfrA17, aadA1, aadA5, strA, tet, and aphA1-Ia in ETEC strains, contributing to multidrug resistance.
Phenotypic and genotypic characterization of Salmonella enterica recovered from poultry meat in Tunisia and identification of new genetic traits.
The study identified various AMR genes in Salmonella enterica isolates from poultry meat in Tunisia, including blaTEM, aadA1, aadA2, dfrA1, sul1, sul2, sul3, strA-strB, cmlA, and tet(A). These genes contribute to resistance against multiple antibiotics such as ampicillin, sulfonamides, streptomycin, trimethoprim, chloramphenicol, and tetracycline.
Genome organization of epidemic Acinetobacter baumannii strains.
The study identifies several beta-lactamase genes (blaOXA-20, blaOXA-23, blaOXA-58, blaOXA-72) and other resistance genes (aadA1, satR, dhfr, merRCAD, feoAB, czc, ars) associated with multidrug resistance in epidemic Acinetobacter baumannii strains.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Discovery and characterization of gene cassettes-containing integrons in clinical strains of Riemerella anatipestifer.
Discovery and characterization of gene cassettes-containing integrons in clinical strains of Riemerella anatipestifer.
IncP-1ε Plasmids are Important Vectors of Antibiotic Resistance Genes in Agricultural Systems: Diversification Driven by Class 1 Integron Gene Cassettes.
Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an α-hemolytic Escherichia coli O108:H- human clinical isolate.
The study identifies a 21.4 kb plasmid pECTm80 carrying a class 2 integron with gene cassettes dfrA1, sat2, and ΔaadA1, which confer resistance to trimethoprim, streptothricin, and streptomycin/spectinomycin respectively.
Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species.
The study demonstrates that natural transformation facilitates the transfer of transposons, integrons, and gene cassettes between bacterial species, leading to the acquisition of antibiotic resistance traits. Specific resistance genes such as aadB, blaIMP-5, blaOXA-30, dfrA12, aadA2, and aacA4 were identified and characterized.
Identification of novel genomic islands and transposons encoding genes that may contribute to host specificity and Salmonella transmission
The study identified various antibiotic resistance genes in Salmonella plasmids, including beta-lactamases (bla CTX, bla CMY, bla TEM), aminoglycoside resistance genes (aadA1, aadA2, strA, strB), tetracycline resistance gene (tetA), chloramphenicol resistance gene (cmlA), sulfonamide resistance gene (sul2), and genes conferring resistance to heavy metals and disinfectants (sugE, arsR, cusR, silE, qacH).
Development and Evaluation of a Microarray-Based Serogenotyping Assay for Salmonella
The study presents a microarray-based serogenotyping assay for Salmonella, demonstrating high correlation between genotypic and phenotypic characteristics. Several AMR genes were identified and validated, showing strong association with AMR phenotypes.
Comparative sequence analysis of a multidrug-resistant plasmid from Aeromonas hydrophila.
The study identifies multiple AMR genes in the multidrug-resistant plasmid pR148 from Aeromonas hydrophila, including blaOXA-10, aadA1, sul1, catA2, and tetA, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, chloramphenicol, and tetracyclines, respectively.
Phylogenetic diversity, antibiotic resistance and virulence traits of Aeromonas spp. from untreated waters for human consumption.
Identification and characterization of integron-mediated antibiotic resistance in the phytopathogen Xanthomonas oryzae pv. oryzae.
The study identifies and characterizes the aacA3, arr3, and aadA1 genes within class 1 integrons in Xanthomonas oryzae pv. oryzae, which confer resistance to various aminoglycosides and rifampicin.
Identification and characterization of integron-mediated antibiotic resistance in the phytopathogen Xanthomonas oryzae pv. oryzae.
Molecular clonality and antimicrobial resistance in Salmonella enterica serovars Enteritidis and Infantis from broilers in three Northern regions of Iran.
The study identified multiple antimicrobial resistance genes, including aadA1, floR, dfrA14, sulI, and tetA, in Salmonella enterica serovars Enteritidis and Infantis from broilers in Iran. These genes were associated with resistance to streptomycin, florfenicol, trimethoprim, sulfamethoxazole, and tetracycline, respectively. Additionally, a single mutation in the gyrA gene was found to confer resistance to nalidixic acid and ciprofloxacin.
Uropathogenic Escherichia coli in Iran: serogroup distributions, virulence factors and antimicrobial resistance properties.
The study identified aadA1 and qnr as the most prevalent antibiotic resistance genes in UPEC strains, with high resistance to penicillin and tetracycline.
Into the wild: dissemination of antibiotic resistance determinants via a species recovery program.
Class 1 integrons containing gene cassettes encoding resistance to streptomycin, spectinomycin, and trimethoprim were detected in captive brush-tailed rock wallabies, suggesting acquisition from human or domestic animal sources.
Chronological Change of Resistance to β-Lactams in Salmonella enterica serovar Infantis Isolated from Broilers in Japan.
The study identified the emergence of Salmonella enterica serovar Infantis isolates carrying blaTEM-52, blaTEM-20, blaCTX-M-25, and blaCMY-2 genes, which confer resistance to extended-spectrum cephalosporins and other beta-lactams. Additionally, non-beta-lactam resistance genes such as aadA1, sul1, tet(A), and aphA1-Iab were prevalent.
Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements.
The study identifies multiple AMR genes and resistance islands in three multidrug-resistant Acinetobacter baumannii isolates, highlighting the role of genomic plasticity in the dissemination of resistance mechanisms.
Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.
The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.
Draft Whole-Genome Sequence of VIM-1-Producing Multidrug-Resistant Enterobacter cloacae EC_38VIM1.
The study identifies the presence of multiple antibiotic resistance genes in the multidrug-resistant Enterobacter cloacae strain EC_38VIM1, including the metallo-beta-lactamase gene blaVIM-1, aadA1, aacA4, qnrA1, catB2, and dfrB1.
NDM-1 Metallo-β-Lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal.
The study identifies multidrug-resistant Providencia rettgeri clinical isolates in Nepal carrying bla NDM-1, bla OXA-72, and armA genes, which confer resistance to carbapenems and aminoglycosides.
Diversity of plasmids encoding resistance and virulence functions in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains circulating in Europe.
The study identifies various AMR genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains, including aac(3)-IV, bla TEM-1, cmlA1, aadA1, aadA2, strA, sul1, sul2, sul3, tet(A), tet(B), and dfrA12, which confer resistance to multiple antibiotics.
Characterization of Escherichia coli virulence genes, pathotypes and antibiotic resistance properties in diarrheic calves in Iran.
The study identified several antibiotic resistance genes in E. coli isolates from diarrheic calves in Iran, including aadA1, sul1, aac[3]-IV, dfrA1, tetA, and tetB, which confer resistance to streptomycin, sulfonamide, gentamicin, trimethoprim, and tetracycline.
Antimicrobial resistance, virulence profiles and molecular subtypes of Salmonella enterica serovars Typhi and Paratyphi A blood isolates from Kolkata, India during 2009-2013.
The study identified several AMR genes in Salmonella enterica serovars Typhi and Paratyphi A, including blaTEM-1, catA, sul1, sul2, dfrA15, aadA1, strA, strB, and intI1, which contribute to resistance against various antibiotics such as ampicillin, chloramphenicol, co-trimoxazole, streptomycin, and others.
Proteus genomic island 1 (PGI1), a new resistance genomic island from two Proteus mirabilis French clinical isolates.
The contribution of Escherichia coli from human and animal sources to the integron gene pool in coastal waters.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Prevalence of virulence determinants and antimicrobial resistance among commensal Escherichia coli derived from dairy and beef cattle.
The study identified several antimicrobial resistance genes in commensal E. coli from dairy and beef cattle, including blaTEM, blaSHV, aadA1, tetA, tetB, and tetC. These genes conferred resistance to ampicillin, streptomycin, and tetracycline. Dairy cattle isolates showed higher resistance rates compared to beef cattle.
Transferable antibiotic resistance plasmids from biogas plant digestates often belong to the IncP-1ε subgroup.
The study identified IncP-1ε plasmids carrying genes such as tet(A), sul1, qacEΔ1, intI1, and aadA1, which confer resistance to tetracycline, sulfadiazine, quaternary ammonium compounds, and streptomycin.
Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subspecies enterica serovar Choleraesuis strains, including blaTEM, strA, strB, aadA1, aadA2, aphA1, aacC2, tetB, sul1, sul2, dhfrXII, and dhfrXIII. Additionally, mutations in the QRDRs of gyrA and parC were associated with quinolone resistance.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Insight into the mobilome of Aeromonas strains.
The study characterizes various antibiotic resistance genes (ARG) in Aeromonas strains, highlighting the presence of beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others. These genes are often located on plasmids and contribute to multidrug resistance.
Draft genome sequence of blaVeb-1, blaoxa-10 producing multi-drug resistant (MDR) Pseudomonas aeruginosa strain VRFPA09 recovered from bloodstream infection.
The study reports the draft genome sequence of MDR Pseudomonas aeruginosa strain VRFPA09, identifying several AMR genes including blaVeb-1, blaOXA-10, aadA1, aph(3')Iib, Sul1, CatB7, TetG, dfrB5, and fosA, which contribute to resistance against various antibiotics.
Molecular characterization of multidrug-resistant Klebsiella pneumoniae isolates.
The study identified several AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (bla SHV, bla TEM, bla CTX-M), aminoglycoside resistance genes (aacC1, aacC4, aadA1, strB), carbapenemase (bla KPC-2), and quinolone resistance gene (qnrB). Additionally, a gyrA mutation (S83L) was found to confer quinolone resistance.
Environmental Isolate of Rahnella aquatilis Harbors Class 1 Integron.
The study reports the first description of a class 1 integron in an environmental isolate of Rahnella aquatilis, harboring the dfrA1-aadA1 gene cassette array and the blaTEM gene, contributing to resistance against trimethoprim, streptomycin, spectinomycin, ampicillin, and piperacillin.
Evolution of AbGRI2-0, the Progenitor of the AbGRI2 Resistance Island in Global Clone 2 of Acinetobacter baumannii.
The study identifies several AMR genes in the A320 strain of Acinetobacter baumannii, including blaTEM, aacC1, aadA1, sul1, catA1, and aphA1b, which confer resistance to various antibiotics.
Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism.
The study identified blaOXA-23 and blaAmpC genes contributing to carbapenem and extended-spectrum cephalosporin resistance, and mutations in pmrA, pmrB, lpxD, lpxC, and lpsB genes linked to polymyxin resistance in A. baumannii AC30.
The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids.
The study characterizes the multidrug-resistant plasmid pEC302/04 from an extraintestinal pathogenic E. coli strain, identifying several AMR genes including blaTEM-1, aadA1, aadB, cmlA, and sul1, which confer resistance to various antibiotics.
Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates.
The study identified various aminoglycoside resistance genes and novel transposons, including Tn6279, ΔTn6279, and Tn1548-like structures, contributing to the resistance of carbapenem-resistant Acinetobacter baumannii isolates.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella.
The study identified 65 unique resistance genes in nontyphoidal Salmonella, including bla CTX-M1 and bla SHV2a, which were first reported in retail meat isolates in the United States. The research highlights the effectiveness of whole-genome sequencing in detecting antimicrobial resistance genes and correlating them with phenotypic resistance.
Corrected Genome Annotations Reveal Gene Loss and Antibiotic Resistance as Drivers in the Fitness Evolution of Salmonella enterica Serovar Typhimurium.
The study identifies antibiotic resistance genes and genomic islands in Salmonella enterica serovar Typhimurium, highlighting the role of horizontal gene transfer in the acquisition of multidrug resistance and fitness-related genes.
Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples.
The study identifies the bla NDM-1 gene as a major cause of carbapenem resistance in Vibrio fluvialis isolates from Kolkata, India. Several additional resistance genes, including aadA1, aadB, aac(6')-Ib-cr, sul1, sul3, floR, bla OXA-1, bla OXA-7, bla OXA-9, bla TEM-9, bla CTX-M-3, strA, and tetB, were also characterized.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates.
The study identifies carbapenem-resistant Acinetobacter indicus-like isolates from cattle carrying the blaOXA-23 gene, along with various other AMR genes such as aac(3)-IIa, strA/B, aph(3')-Ic, sul2, floR, tet(A), tet(Y), aadA1, aadB, sul1, and tet(X).
Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains.
The study identifies several AMR genes in ST95 E. coli strains, including blaTEM-1, blaCTX-M14, aadA1, aadA2, aadA5, aac3, strA, strB, tetA, tetB, tetD, sul1, sul2, dfrA5, dfrA12, dfrA17, mphA, and catA1, which confer resistance to various antibiotics such as ampicillin, cephalothin, streptomycin, tetracycline, sulfamethoxazole, trimethoprim, azithromycin, and chloramphenicol.
Multidrug Resistance Salmonella Genomic Island 1 in a Morganella morganii subsp. morganii Human Clinical Isolate from France.
The study reports the first identification of Salmonella genomic island 1 (SGI1) in a multidrug-resistant clinical isolate of Morganella morganii subsp. morganii, carrying resistance genes dfrA15, floR, tetA(G), blaCARB-2, and sul1, conferring resistance to trimethoprim, chloramphenicol, tetracycline, ticarcillin, and sulfonamides, respectively.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Biofilm Formation Potential of Heat-Resistant Escherichia coli Dairy Isolates and the Complete Genome of Multidrug-Resistant, Heat-Resistant Strain FAM21845.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant, heat-resistant E. coli strain FAM21845, including beta-lactamase blaTEM-1, aminoglycoside resistance genes strA, strB, aadA1, aph(3')-Ic, aph(4)-Ia, aac(3)-IVa, sulfonamide resistance gene sul1, trimethoprim resistance gene dfrA1, tetracycline resistance gene tet(B), disinfectant resistance gene qacEΔ1, and biofilm-related genes mrkABCDF. Additionally, the strain carried genes for resistance to arsenic, silver, and copper.
Characterization of a Large Antibiotic Resistance Plasmid Found in Enteropathogenic Escherichia coli Strain B171 and Its Relatedness to Plasmids of Diverse E. coli and Shigella Strains.
The study characterized a large antibiotic resistance plasmid, pB171_90, from EPEC strain B171, identifying several AMR genes including aadA1, sul1, tetA, tetR, qacE Δ 1, csi, hha, and traI.
Molecular determination of antimicrobial resistance in Escherichia coli isolated from raw meat in Addis Ababa and Bishoftu, Ethiopia.
The study identified several AMR genes in E. coli isolates from raw meat, including blaCMY, tet(A), and sul1, which confer resistance to beta-lactams, tetracyclines, and sulfonamides, respectively.
Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds.
The study identified multiple antibiotic resistance genes, including sul1, sul2, floR, aadA1, aac(6')-Ib, blaTEM, blaCTX-M, blaPSE, blaNDM-1, qacEΔ1, pcoA/copA, chrB, and pcoR, in bacterial isolates from seafood. These genes conferred resistance to sulfonamides, phenicols, aminoglycosides, beta-lactams, and heavy metals.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
VIM-1 carbapenemase-producing Escherichia coli isolated from retail seafood, Germany 2016.
The study identifies a VIM-1 carbapenemase-producing E. coli isolate from retail seafood in Germany, highlighting the presence of multiple resistance genes including blaVIM-1, aacA4, aadA1, aph(3')-XV, catB2, qnrS1, blaSHV-12, blaACC-1, strA-like, strB-like, dfrA14-like, mph(A), sul1, and sul2.
New eight genes identified at the clinical multidrug-resistant Acinetobacter baumannii DMS06669 strain in a Vietnam hospital.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Acinetobacter baumannii DMS06669 strain, including eight novel genes not previously reported in A. baumannii. These genes conferred resistance to various antibiotic classes, including aminoglycosides, beta-lactams, phenicols, sulfonamides, tetracyclines, macrolides, lincosamides, streptogramin B, and rifampicins.
A Novel IncA/C1 Group Conjugative Plasmid, Encoding VIM-1 Metallo-Beta-Lactamase, Mediates the Acquisition of Carbapenem Resistance in ST104 Klebsiella pneumoniae Isolates from Neonates in the Intensive Care Unit of V. Monaldi Hospital in Naples.
The study identifies a novel IncA/C1 conjugative plasmid, pIncAC_KP4898, which carries the blaVIM-1 gene and other resistance genes, mediating carbapenem resistance in ST104 Klebsiella pneumoniae isolates from neonates in the NICU of V. Monaldi Hospital in Naples.
Characterization of multiple antibiotic resistance of culturable microorganisms and metagenomic analysis of total microbial diversity of marine fish sold in retail shops in Mumbai, India.
The study identified multiple antibiotic resistance genes in marine fish isolates, including blaTEM, Class I integron, tetA, aph(3')-IIIa, ermB, aadA, and sul1, indicating a potential risk of antibiotic resistance transmission to humans through the food chain.
Characterization of Salmonella enterica isolates causing bacteremia in Lima, Peru, using multiple typing methods.
The study identified aadA1 and dfrA1 genes in Salmonella isolates, which confer resistance to streptomycin, spectinomycin, and trimethoprim. These genes were found in Infantis and Dublin isolates, respectively.
High Prevalence of CTX-M-15-Type ESBL-Producing E. coli from Migratory Avian Species in Pakistan.
The study identified a high prevalence of CTX-M-15-type ESBL-producing E. coli in migratory avian species in Pakistan, highlighting the role of wild birds as reservoirs of multidrug-resistant bacteria and the potential for horizontal gene transfer of resistance determinants.
A Highly Promiscuous Integron, Plasmids, Extended Spectrum Beta Lactamases and Efflux Pumps as Factors Governing Multidrug Resistance in a Highly Drug Resistant Vibrio fluvialis Isolate BD146 from Kolkata, India.
The study identified several AMR genes and mutations contributing to multidrug resistance in Vibrio fluvialis BD146, including blaOXA10, arr3, aadA1, cmlA, dfrVI, qnrVC5, and BDint, as well as mutations in gyrA and parC.
pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions.
The IncHI2 plasmid pSTM6-275 from Salmonella enterica carries multiple antibiotic and heavy-metal resistance genes, including blaTEM, strA, strB, sul3, aadA1, aadA2, cmlA, aphA2, tetA, mejB, silESRCFBAGP, and pcoGE1ABCDRSE2, which confer resistance to various antibiotics and metals. The plasmid exhibits temperature-dependent resistance to silver and copper, highlighting its adaptability under changing physiological conditions.
Impact of Wastewater Treatment on the Prevalence of Integrons and the Genetic Diversity of Integron Gene Cassettes.
The study identified various antibiotic resistance genes within integron gene cassettes in wastewater treatment plants, including aadA1, aadA2, aadA5, blaOXA-1, blaOXA-10, blaOXA-101, blaOXA-129, blaOXA-21, blaOXA-28, catB8, dfrA14, erm, qacE2, sul1, tet, orfD, and orfA, which confer resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, tetracyclines, and quaternary ammonium compounds.
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China.
The study identified multiple antimicrobial resistance genes in Haemophilus parasuis isolates from pigs in China, including blaTEM-1, blaROB-1, ermB, ermA, flor, catl, tetB, tetC, rmtB, rmtD, aadA1, aac(3′)-IIc, sul1, and sul2. Additionally, mutations in the gyrA and parC genes were associated with fluoroquinolone resistance.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenylyltransferase.
Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenylyltransferase.
Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenylyltransferase.
Isolation, Functional Characterization and Transmissibility of p3PS10, a Multidrug Resistance Plasmid of the Fish Pathogen Piscirickettsia salmonis.
The study identifies and characterizes the multidrug resistance plasmid p3PS10 in Piscirickettsia salmonis, which carries genes conferring resistance to chloramphenicol (cat2), tetracyclines (tetA(t31)), aminoglycosides (aadA1, sat1), and sulfonamides (sul2).
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
Gene cassettes of class I integron-associated with antimicrobial resistance in isolates of Citrobacter spp. with multidrug resistance.
The study identified several gene cassettes associated with antimicrobial resistance in multidrug-resistant Citrobacter isolates, including aadA1, aadA2, dfrA1, dfrA12, dfrA15, dfrA1-aadA1, and dfrA12-orfF-aadA2.
Genetic analysis of invasive Escherichia coli in Scotland reveals determinants of healthcare-associated versus community-acquired infections.
The study identified several antibiotic resistance genes in E. coli isolates, including blaCTX-M-15, blaCTX-M-9, aac(3)-II, aac(6')-Ib, aadA1, dfrA1, sul1, sul2, mphA, and mrxA, which contribute to resistance against various antibiotics such as third-generation cephalosporins, aminoglycosides, trimethoprim, sulfonamides, and macrolides.
Characterization of NDM-Encoding Plasmids From Enterobacteriaceae Recovered From Czech Hospitals.
The study characterized NDM-encoding plasmids from Enterobacteriaceae isolates in Czech hospitals, identifying blaNDM-1, blaNDM-4, and blaNDM-5 genes as the primary resistance determinants.
Tracing back multidrug-resistant bacteria in fresh herb production: from chive to source through the irrigation water chain.
The study identified multidrug-resistant bacteria in irrigation water and chive, highlighting the role of water quality in the transmission of antibiotic-resistant bacteria. Key resistance genes included blaCTX-M-15, mphA, and tet(A).
Antimicrobial Resistance in Commensal Escherichia coli Isolated from Pigs and Pork Derived from Farms Either Routinely Using or Not Using In-Feed Antimicrobials.
The study identified aadA1, aadA2, aadB, and bla CTX-M-1 as the primary AMR genes in commensal E. coli from pigs and pork, with higher prevalence in farms using in-feed antimicrobials.
Antimicrobial resistance genes in pathogenic Escherichia coli isolated from diseased broiler chickens in Egypt and their relationship with the phenotypic resistance characteristics.
The study identified multiple antimicrobial resistance genes in pathogenic E. coli isolates from broiler chickens in Egypt, including CITM, ere, aac(3)-(IV), tet(A), tet(B), dfr(A1), and aad(A1). These genes were associated with resistance to various antibiotics, highlighting the presence of multidrug-resistant E. coli in poultry.
Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance.
High levels of Bifidobacterium in early life are associated with reduced levels of antimicrobial resistance (AMR) in the gut microbiome. Specifically, the gene ermX, encoding a 23S rRNA methyltransferase, was found to be significantly enriched in high-Bifidobacterium samples and is associated with resistance to macrolides, lincosamides, and streptogramin B.
Interplay Between the Phenotype and Genotype, and Efflux Pumps in Drug-Resistant Strains of Riemerella anatipestifer.
The study identified multiple AMR genes and mutations in Riemerella anatipestifer, including aac(6')-Ib, aadA1, aadA2, aadA5, aac(3')-IIc, aac(3')-IV, aph(3')-VII, aph(2')-Ib, bla TEM, bla OXA, tet(A), tet(B), sul1, sul2, sul3, cat2, cmlA, floR, emrF, qnrS, and qnrD. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.
Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms.
The study identified tetracycline resistance genes tet(A) and tet(B) as the most common in commensal E. coli isolates from cattle farms, along with gene cassettes such as aadA1, dfrA1, dfrA12, sul1, cat1, and floR associated with class 1 integrons.
Genome sequence analysis of an extensively drug-resistant Acinetobacter baumannii indigo-pigmented strain depicts evidence of increase genome plasticity.
The study identifies multiple antibiotic resistance genes in the extensively drug-resistant Acinetobacter baumannii strain Ab33405, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, highlighting the genetic basis of its multidrug resistance.
Investigation of a Carbapenemase-producing Acinetobacter baumannii outbreak using whole genome sequencing versus a standard epidemiologic investigation.
The study identified the carbapenemase gene blaOXA-237 and intrinsic blaOXA-66 as responsible for carbapenem resistance in Acinetobacter baumannii. Aminoglycoside resistance was mediated by aadA1, aph(3')-Ia, armA, strA, and strB. Quinolone resistance was due to mutations in GyrA (Ser-83-Leu) and ParC (Ser-80-Leu).
High abundances of class 1 integrase and sulfonamide resistance genes, and characterisation of class 1 integron gene cassettes in four urban wetlands in Nigeria.
The study identified high abundances of class 1 integrase (intI1) and sulfonamide resistance genes (sul1 and sul2) in urban wetlands in Nigeria, along with various gene cassettes in class 1 integrons that confer resistance to trimethoprim, aminoglycosides, rifampicin, and fluoroquinolones.
Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.
The study shows that Acinetobacter baumannii A118 can acquire antibiotic resistance genes from other species through natural transformation, leading to increased resistance to various antibiotics such as meropenem, imipenem, and sulfamethoxazole.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
Whole-genome analysis of extraintestinal Escherichia coli sequence type 73 from a single hospital over a 2 year period identified different circulating clonal groups.
The study identified multiple antibiotic resistance genes, including aadA1, sul1, and blaOXA-1, in ST73 isolates from a hospital in Sydney, highlighting the diversity of resistance mechanisms in these strains.
Characterisation of antibiotic resistance of Salmonella isolated from dog treats in Japan.
The study identified the presence of antibiotic-resistant Salmonella in dog treats in Japan, including the blaTEM gene, aadA1, aadA2, tetB, floR, catA1, dfrA12, and intI1 genes, indicating multidrug resistance.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Prevalence of antimicrobial resistance and potential pathogenicity, and possible spread of third generation cephalosporin resistance, in Escherichia coli isolated from healthy chicken farms in the region of Dakar, Senegal.
The study identified various AMR genes and mutations in E. coli isolates from healthy chicken farms in Senegal, including bla CTX-M, bla CMY-2, tetA, dfrA1, dfrA7, aadA1, qnrB, and bla TEM, as well as mutations in gyrA and parC genes contributing to ciprofloxacin resistance.
Rapid Replacement of Acinetobacter baumannii Strains Accompanied by Changes in Lipooligosaccharide Loci and Resistance Gene Repertoire.
The study identified various AMR genes in clade F strains of Acinetobacter baumannii, including blaOXA-23, aadB, aadA2, aphA6, aacC1, aadA1, and armA, which confer resistance to multiple antibiotics.
Phenotypic and genotypic characterization of enterotoxigenic Escherichia coli isolated from diarrheic calves in Argentina.
The study identified multidrug-resistant ETEC strains from diarrheic calves in Argentina, including the presence of integrons carrying resistance genes such as dhfrA1, aadA1, dhfrA17, aadA5, and sul1.
Antimicrobial resistance, virulence & plasmid profiles among clinical isolates of Shigella serogroups.
The study identified multiple antimicrobial resistance genes including bla OXA-1, bla TEM-1B, qnr S1, dfr A1, aad A1, sul II, tet B, and cat A1 in Shigella isolates. Additionally, novel mutations in gyr A, gyr B, par C, and par E genes were observed, contributing to quinolone resistance.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Characterization of Non-O157 Escherichia coli from Cattle Faecal Samples in the North-West Province of South Africa.
The study identified several antimicrobial resistance genes in non-O157 E. coli isolates from cattle fecal samples, including tetA, tetB, blaTEM-1, aadA1, and catA1, which were associated with resistance to tetracycline, ampicillin, streptomycin, and chloramphenicol.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Isolation and Antibiotic Resistant Research of Tetragenococcus halophilus from Xuanwei Ham, A China High-Salt-Fermented Meat Products.
The study identified several antibiotic resistance genes in Tetragenococcus halophilus strains isolated from Xuanwei ham, including acrB, blaTEM, AAda1, SulII, and GyrB, which confer resistance to aminoglycosides, beta-lactams, sulfonamides, and quinolones.
Manure Application Did Not Enrich Antibiotic Resistance Genes in Root Endophytic Bacterial Microbiota of Cherry Radish Plants.
The study found that manure application increased the occurrence of antibiotic resistance genes (ARGs) in the rhizosphere and phyllosphere of cherry radish, but not in the endophytic bacterial microbiota of the root, which is the edible part of the plant.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene.
The study identifies the chromosomally-encoded mcr-1 gene in a colistin-resistant E. coli ST695 strain, along with various other resistance genes such as bla NDM-1, aadA1, aadA2, aph(3')-Ia, aph(3')-VI, rmtB, cmlA1, floR, tet(A), tet(M), dfrA12, oqxA, oqxB, qnrS1, mph(A), bla TEM-105, and bla TEM-1B, contributing to its multidrug-resistant phenotype.
WGS based study of the population structure of Salmonella enterica serovar Infantis.
The study identified multiple resistance genes, including aadA1, sul1, tetA, and dfrA14, carried on a pESI-like plasmid in multidrug-resistant Salmonella enterica serovar Infantis strains.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Emerging Variants of the Integrative and Conjugant Element ICEMh1 in Livestock Pathogens: Structural Insights, Potential Host Range, and Implications for Bacterial Fitness and Antimicrobial Therapy.
The study identified multiple antimicrobial resistance genes within the ICE Mh1 PM22, including aminoglycoside, sulfonamide, macrolide, and tetracycline resistance genes. These genes contribute to multidrug resistance in livestock pathogens.
Effects of a Four-Week High-Dosage Zinc Oxide Supplemented Diet on Commensal Escherichia coli of Weaned Pigs.
The study identifies several antibiotic resistance genes (ARGs) and zinc tolerance genes in commensal Escherichia coli from weaned pigs, highlighting the impact of high-dose zinc oxide diets on selecting for resistant strains.
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Genomic Characterization of New Variant of Hydrogen Sulfide (H(2)S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China †
The study reports the first detection of a hydrogen sulfide (H2S)-producing Escherichia coli variant isolated from a human in China, with multidrug resistance properties, including colistin resistance mediated by the mcr-1 gene, along with other resistance genes such as aadA1, aadA2, dfrA12, blaTEM-1B, oqxA, oqxB, floR, cmlA1, sul3, and tet(A).
Molecular Detection of Multidrug Resistant Salmonella Species Isolated from Broiler Farm in Bangladesh.
The study identified multidrug-resistant Salmonella enterica serovar Typhimurium isolates from broiler farms in Bangladesh, carrying resistance genes tetA, floR, blaTEM-1, aadA1, and class 1 integron gene intl1.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Prevalence, Antimicrobial Resistance, Virulence Genes and Genetic Diversity of Salmonella Isolated from Retail Duck Meat in Southern China.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from retail duck meat in Southern China, including blaTEM, blaCTX-M, strA, aadA1, qnrS, aac(6')-Ib, qnrB, and floR, which confer resistance to various antibiotics such as ampicillin, cefotaxime, streptomycin, ciprofloxacin, ofloxacin, and florfenicol.
Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
The study evaluated the performance of various bioinformatics tools for predicting antimicrobial resistance (AMR) and serotypes of Salmonella enterica using whole-genome sequencing (WGS). It identified several AMR genes and mutations associated with resistance to various antibiotics.
Pathotypes and Antimicrobial Susceptibility of Escherichia Coli Isolated from Wild Boar (Sus scrofa) in Tuscany.
The study identified various antimicrobial resistance genes in E. coli isolates from wild boar in Tuscany, including blaCMY-2, sul1, sul2, tetG, aadA1, and strA-strB, indicating significant resistance to beta-lactams, sulfonamides, tetracyclines, and streptomycin.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Whole Genome Sequencing Analysis of Porcine Faecal Commensal Escherichia coli Carrying Class 1 Integrons from Sows and Their Offspring.
The study identified multiple antimicrobial resistance genes in porcine faecal commensal E. coli, including blaTEM-1, strA, strB, tetA, dfrA12, aadA1, aadA2, cmlA, aph(3')-Ia, sul2, and sul3, which confer resistance to beta-lactams, streptomycin, tetracyclines, trimethoprim, aminoglycosides, chloramphenicol, neomycin, kanamycin, and sulfonamides.
Genomic Characterisation of a Multiple Drug Resistant IncHI2 ST4 Plasmid in Escherichia coli ST744 in Australia.
The study describes the first complete sequence of a multiple drug-resistant IncHI2 ST4 plasmid, pTZ41_1P, from a commensal E. coli in Australia. The plasmid carries genes conferring resistance to heavy metals, beta-lactams, aminoglycosides, and sulfonamides.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Phenotypic and Genotypic Properties of Vibrio cholerae non-O1, non-O139 Isolates Recovered from Domestic Ducks in Germany.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii.
The study shows that removing the AbaR resistance island from Acinetobacter baumannii restores antibiotic susceptibility and increases natural transformability. Several AMR genes within AbaR were identified, including aadB, aacC1, aphA1b, aacA, aadA1, strA, strB, blaVEB-1, blaOXA-10, sul1, dhfrI, dhfrX, tetA(A), tetA(G), cmlA1, cmlA5, cmlA9, catA1, arr-2, and sup.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Genomic insights of Klebsiella pneumoniae isolated from a native Amazonian fish reveal wide resistome against heavy metals, disinfectants, and clinically relevant antibiotics.
The study identifies a multidrug-resistant Klebsiella pneumoniae strain carrying several AMR genes, including blaCTX-M-15, blaTEM-1B, blaSHV-27, aac(3)-IId, aadA1, sul2, tetB, tetD, fosA-like, oqxA, oqxB, and qnrE1, highlighting the potential of native Amazonian fish as reservoirs of clinically relevant AMR genes.
Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii.
The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.
Characterization of Multidrug Resistance Patterns of Emerging Salmonella enterica Serovar Rissen along the Food Chain in China.
The study identified multiple AMR genes in Salmonella enterica serovar Rissen isolates, including tet(A), blaTEM-1B, aadA2, aadA1, aac(6')-Iaa, aph(3")-lld, sul3, and dfrA12, which confer resistance to various antibiotics such as tetracycline, ampicillin, streptomycin, sulfisoxazole, and trimethoprim-sulfamethoxazole.
Bacterial Genome Wide Association Studies (bGWAS) and Transcriptomics Identifies Cryptic Antimicrobial Resistance Mechanisms in Acinetobacter baumannii.
The study identified several AMR genes and mutations in Acinetobacter baumannii, including beta-lactamases like blaOXA-23, blaOXA-64, and blaOXA-235, as well as aminoglycoside resistance genes like aadA1 and AAC(3)-Ia. It also found a gyrA S82L mutation associated with quinolone resistance.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.
Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
Distribution of Antibiotic-Resistant Enterobacteriaceae Pathogens in Potable Spring Water of Eastern Indian Himalayas: Emphasis on Virulence Gene and Antibiotic Resistance Genes in Escherichia coli.
The study identified antibiotic resistance genes CITM, aadA1, tetO, and qnrB in Escherichia coli isolates from spring water in Sikkim, indicating the presence of multidrug-resistant Enterobacteriaceae.
Isolation and molecular characterization of multidrug-resistant Escherichia coli from chicken meat.
The study identified multiple antibiotic resistance genes in multidrug-resistant E. coli isolates from chicken meat, including tetA, sul1, aadA1, ereA, aac-3-IV, cmlA, catA1, SHV, and CITM, highlighting the prevalence of resistance to various antibiotics such as tetracycline, sulfonamide, streptomycin, erythromycin, gentamicin, chloramphenicol, and beta-lactams.
Genomic and phenotypic analyses of multidrug-resistant Acinetobacter baumannii NCCP 16007 isolated from a patient with a urinary tract infection.
The study identifies multiple AMR genes and mutations in the multidrug-resistant A. baumannii NCCP 16007 strain, including pmrC, pmrB, blaOXA-23, and various aminoglycoside, tetracycline, and beta-lactam resistance genes, contributing to its high resistance to polymyxin B and other antibiotics.
Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.
The study reports the emergence of the mcr-9.1 gene in a colistin-resistant Enterobacter kobei strain isolated from a critically endangered franciscana dolphin in Brazil, along with various other AMR genes.
Genomic Characterization of VIM and MCR Co-Producers: The First Two Clinical Cases, in Italy.
The study characterizes two clinical Enterobacter cloacae complex isolates co-producing VIM and MCR enzymes, identifying specific AMR genes and their resistance mechanisms.
Colistin Dependence in Extensively Drug-Resistant Acinetobacter baumannii Strain Is Associated with ISAjo2 and ISAba13 Insertions and Multiple Cellular Responses.
The study identifies the disruption of lpxA, mlaD, and pldA genes by IS Ajo2 and IS Aba13 insertions in colistin-dependent A. baumannii, leading to lipid A deficiency and colistin dependence.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Collateral sensitivity associated with antibiotic resistance plasmids.
The study identifies several AMR genes carried by clinically relevant plasmids, including blaOXA-48, qnrS1, blaSHV-12, aac(6')-Ib3, blaVEB-9, qnrVC-1, sul1, tetA', tetC, dfrA1, dfrA23, blaVIM-1, aadA1, qacEΔ1, blaBEL-1, blaGES-5, blaIMP-8, and blaFOX-8. These genes confer resistance to various antibiotics, and the study highlights the collateral sensitivity associated with the acquisition of these plasmids.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
A Preliminary Study: Antibiotic Resistance of Escherichia coli and Staphylococcus aureus from the Meat and Feces of Various South African Wildlife Species.
The study identified antibiotic resistance genes in Escherichia coli and Staphylococcus aureus from wildlife meat and feces, including blaCMY, aadA, sul1, sul2, tetA, tetB, tetK, tetL, tetM, vanA, vanB, and blaZ, which conferred resistance to ampicillin, streptomycin, sulfonamides, tetracycline, vancomycin, and penicillin.
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
The study identified several AMR genes in Salmonella isolates from Kenya, including blaTEM-1, aadA1, strA, strB, catA1, dhfr1, sul1, and sul2, which confer resistance to various antibiotics such as penicillins, cephalosporins, streptomycin, chloramphenicol, trimethoprim, and sulfonamides.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Analysis of antibiotic resistance phenotypes and genes of Escherichia coli from healthy swine in Guizhou, China.
The study identified multiple antibiotic resistance genes in Escherichia coli isolates from healthy swine in Guizhou, China, highlighting the prevalence of multidrug resistance, particularly for tetracycline, doxycycline, and sulfisoxazole. Key genes included blaTEM, blaCTX-M-9G, aac(3')-IV, aadA1, aadA2, floR, qnrS, oqxA, and mcr-1.
Molecular Detection of Antibiotic Resistance Genes in Shiga Toxin-Producing E. coli Isolated from Different Sources.
The study identified multiple antibiotic resistance genes in Shiga toxin-producing E. coli (STEC) isolates, including aadA1, aac(3)-I, ere(A), ampC, blaSHV, blaCMY, and tet(A), which conferred resistance to various antibiotics such as streptomycin, gentamicin, erythromycin, ampicillin, penicillin, cephalosporin, and tetracycline.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Limited and Strain-Specific Transcriptional and Growth Responses to Acquisition of a Multidrug Resistance Plasmid in Genetically Diverse Escherichia coli Lineages.
The study identified the ESBL plasmid pLL35 carrying blaCTX-M-15, TEM-112, and OXA-9, which conferred varying levels of cefotaxime resistance across different E. coli strains. The transcriptional response to plasmid acquisition was limited and strain-specific, with minimal global changes in gene expression.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
The study identified various beta-lactam-resistant Escherichia coli strains from Australian fruit bats, highlighting the presence of multiple AMR genes such as bla TEM-1A, bla TEM-1B, bla CTX-M-27, bla NDM-5, and others, indicating anthropogenic origins of these resistant strains.
Molecular Characterization of Multidrug-Resistant Yersinia enterocolitica From Foodborne Outbreaks in Sweden.
The study identified a chromosomally encoded multidrug-resistance cassette carrying resistance genes against chloramphenicol (catA1), streptomycin (aadA1), sulfonamides (sul1), and a mercury resistance module, as well as a 5.7-kbp plasmid with tetB encoding an ABC transporter in Yersinia enterocolitica strains from a foodborne outbreak in Sweden.
Genomic Insights into Drug Resistance and Virulence Platforms, CRISPR-Cas Systems and Phylogeny of Commensal E. coli from Wildlife.
The study identified various AMR genes in commensal E. coli strains from wildlife, including bla TEM-1, bla CTX-M-1, tet(A), tet(B), and several resistance gene cassettes in integrons. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of AMR in wildlife E. coli populations.
WGS-Based Analysis of Carbapenem-Resistant Acinetobacter baumannii in Vietnam and Molecular Characterization of Antimicrobial Determinants and MLST in Southeast Asia.
The study identified several AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Vietnam, including bla OXA-51-like, bla OXA-23, bla TEM-1, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, and other antibiotics.
Escherichia coli Antibiotic Resistance Patterns from Co-Grazing and Non-Co-Grazing Livestock and Wildlife Species from Two Farms in the Western Cape, South Africa.
The study identified several antibiotic resistance genes in E. coli isolates from livestock and wildlife, including bla CMY, aad A1, sul 1, sul 2, tet A, and tet B, which conferred resistance to ampicillin, streptomycin, sulfonamides, and tetracycline. The research highlights differences in resistance patterns between co-grazing and non-co-grazing animals.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.
The study identifies various AMR genes in the IncC plasmid pUO-STmRV1, including blaTEM-1, cmlA1, aac(3)-IV, aadA1, aadA2, sul1, sul2, sul3, tet(A), dfrA12, arsR2, arsH, merRTPCADE, and silESRCBAP, which confer resistance to antibiotics and heavy metals.
Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.
The study identified several antibiotic resistance genes (ARGs) in chicken manure, mushroom residues, and heat-treated chicken manure, highlighting the impact of different organic manures on the soil resistome. Key findings include the enrichment of specific ARGs such as aadE, aadD, qacE1, qacH, lnuA, vatE, and tetL in soils treated with various manures, indicating the potential for ARG transfer through manure application.
Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates.
The study identifies several AMR genes including bla OXA-23, bla OXA-24, bla OXA-51, and various aminoglycoside, sulfonamide, tetracycline, and macrolide resistance genes in XDR A. baumannii isolates from Romania.
Function Characterization of Endogenous Plasmids in Cronobacter sakazakii and Identification of p-Coumaric Acid as Plasmid-Curing Agent.
The study identified the aadA1 gene in Cronobacter sakazakii GZcsf-1, which confers resistance to spectinomycin and streptomycin. Additionally, the plasmid pGW1 was found to be associated with multidrug resistance in C. sakazakii GZcsf-1.
Genomic evolution of antimicrobial resistance in Escherichia coli.
The study identified several AMR genes in Escherichia coli isolates from different animal sources in Europe, including blaTEM-1B, qnrB19, qnrS1, sul1, sul2, sul3, tet(A), aadA1, and aph(6)-Id. These genes were associated with resistance to beta-lactams, fluoroquinolones, sulfonamides, tetracyclines, and aminoglycosides.
Detection of bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) Genes Among Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Migratory Birds Travelling to Bangladesh.
The study identified bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) genes in extended-spectrum beta-lactamase-producing Escherichia coli isolated from migratory birds in Bangladesh, highlighting the role of migratory birds as potential carriers of antibiotic resistance genes.
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
The study identified multiple AMR genes and mutations in invasive non-typhoidal Salmonella isolates from sub-Saharan Africa, highlighting the prevalence of multidrug resistance.
Molecular study of metallo-β-lactamases and integrons in Acinetobacter baumannii isolates from burn patients.
High prevalence of MBLs genes, especially blaVIM, was identified in MDR A. baumannii isolates. Most of the strains carried class 1 integrons, and gene cassettes arrays including cmlA5 and cmlA7 were detected for the first time in A. baumannii strains in Iran.
Two carbapenem-resistant ST1:ST231:KL1:OCL1 Acinetobacter baumannii strains recovered in Tehran, Iran, carry AbaR31 in the chromosome and AbaR4 and TnaphA6 in a RepAci6 plasmid.
The study identifies multiple antibiotic resistance genes, including catA1, tetA(A), sul1, aacC1, aadA1, aphA6, and oxa23, in two carbapenem-resistant Acinetobacter baumannii strains, ABH008 and ABS200, highlighting their extensive drug resistance.
Genomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.
The study identified various beta-lactamase genes, including blaSHV-11, blaKPC-2, and blaNDM-1, along with qnrS1, aadA1, dfrA1, and sul1, which contribute to multidrug resistance in extensively drug-resistant Klebsiella pneumoniae isolates.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.
Whole Genome Sequencing of Pediatric Klebsiella pneumoniae Strains Reveals Important Insights Into Their Virulence-Associated Traits.
The study identified various AMR genes in K. pneumoniae strains, including beta-lactamases (blaSHV, blaOXA, blaTEM, blaCTX-M), fosfomycin resistance (fosA), quinolone resistance (oqxA, qnrB), chloramphenicol resistance (catB3), aminoglycoside resistance (aac(3), aadA1, strB), sulfonamide resistance (sul1), trimethoprim resistance (dfrA), and tetracycline resistance (tet(A)).
Antimicrobial Resistance and Whole-Genome Characterisation of High-Level Ciprofloxacin-Resistant Salmonella Enterica Serovar Kentucky ST 198 Strains Isolated from Human in Poland.
The study identified several AMR genes and mutations in high-level ciprofloxacin-resistant Salmonella Enterica serovar Kentucky ST198 strains isolated from humans in Poland, including blaTEM-1B, qnrS1, aac(3)-Id, aac(3)-IId, aac(6')-Iaa, aac(6')-Iid, aph(3")-Ib, aph(3")-Id, aadA1, sul1, dfrA1, and tetA, along with mutations in gyrA and parC that confer resistance to quinolones and beta-lactams.
A One-Health Genomic Investigation of Gentamicin Resistance in Salmonella from Human and Chicken Sources in Canada, 2014 to 2017.
The study identified several aminoglycoside-modifying enzymes, including aac(3)-VIa, aac(3)-IId, aac(3)-Id, aac(3)-IVa, aac(3)-IIa, ant(2′′)-Ia, aac(6′)-Ib-cr, aadA2, aadA7, aadA1, ant(3′′)-Ia, aac(6′)-Ib3, and rmtB, as key contributors to gentamicin resistance in Salmonella isolates from both human and chicken sources in Canada.
Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant K. pneumoniae strain KPE16, including bla NDM-1, bla CTX-M-15, and various aminoglycoside, sulfonamide, and tetracycline resistance genes. Additionally, chromosomal mutations in ompK36, ompK37, and acrR contribute to resistance.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales.
The study characterizes a pESI-like plasmid harboring multiple resistance genes, including bla CTX-M-65, in multidrug-resistant Salmonella enterica Infantis isolates from England and Wales. The plasmid was associated with resistance to beta-lactams, aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, sulfonamides, fosfomycin, and heavy metals.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Carbapenem-Resistant Citrobacter spp. as an Emerging Concern in the Hospital-Setting: Results From a Genome-Based Regional Surveillance Study.
The study identifies various carbapenemase genes, including bla KPC-2, bla OXA-48, bla VIM-1, bla NDM-5, bla OXA-162, and bla KPC-3, in Citrobacter spp. isolates, highlighting their role in carbapenem resistance.
Prevalence of genotypic antimicrobial resistance in clinical Shiga toxin-producing Escherichia coli in Norway, 2018 to 2020.
The study identified a low prevalence of genotypic antimicrobial resistance in clinical STEC in Norway, with aminoglycoside resistance being the most common. Key resistance genes included strA, strB, aadA1, sul1, sul2, tetA, blaTEM-1B, and dfrA1.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Dairy Calf Exposure, United States, 2015-2018.
The study identifies a multidrug-resistant (MDR) Salmonella Heidelberg outbreak linked to dairy calf exposure, highlighting the presence of plasmid-borne resistance genes such as aadA1, aph(3')-Ia, bla CMY-2, floR, fosA7, qnrB19, strA, strB, sull, sul2, tet(A), tet(B), tet(O), and a novel gene dfrA34.
Plethora of Resistance Genes in Carbapenem-Resistant Gram-Negative Bacteria in Greece: No End to a Continuous Genetic Evolution.
The study identified a variety of resistance genes in carbapenem-resistant Gram-negative bacteria, including bla KPC, bla NDM, bla VIM, and others, highlighting the complex genetic diversity of these pathogens.
Anti-microbial resistance of Salmonella isolates from raw meat-based dog food in Japan.
Decreasing the abundance of tetracycline-resistant Escherichia coli in pig feces during nursery using flavophospholipol as a pig feed additive.
Flavophospholipol (FPL) effectively reduced the abundance of tetracycline-resistant Escherichia coli in pig feces by inhibiting conjugational transfer and growth of resistant plasmids carrying tetA, tetB, blaTEM-1B, mdfA, aph(3')-I, sul2, aadA1, and dfrA1.
A Genomic and Bioinformatics View of the Classification and Evolution of Morganella Species and Their Chromosomal Accessory Genetic Elements Harboring Antimicrobial Resistance Genes.
The study identified 88 acquired antimicrobial resistance genes (ARGs) in 166 Morganella isolates, with a focus on tetracycline, aminoglycoside, sulfonamide, trimethoprim, and beta-lactam resistance genes. Key ARGs included blaKPC-2, blaNDM-1, aacA4, aadA5, dfrA17, catB3, arr-3, blaOXA-1, aacA4cr, mph(A), rmtB, sul2, floR, qnrS1, tetA, and ermB.
Distribution and Molecular Characterization of Functional Class 2 Integrons in Clinical Proteus mirabilis Isolates.
The study identified functional class 2 integrons in three Proteus mirabilis isolates, containing gene cassettes dfrA1-sat2-aadA1 and four novel open reading frames. The internal stop codons in intI2 genes were mutated, indicating functional intI2 genes.
HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities.
The study identified various AMR genes, including aadA1, aadA2, blaCFE-1, cmlA1, dfrA12, mdf(A), sul3, tet(34), and lnu(A), in pig fecal microbiomes. Notably, the lnu(A) gene was exclusively found in conventional farms and associated with Lactobacillus species.
Virulome and genome analyses identify associations between antimicrobial resistance genes and virulence factors in highly drug-resistant Escherichia coli isolated from veal calves.
The study identifies multiple antimicrobial resistance genes (ARGs) in highly drug-resistant Escherichia coli isolates from veal calves, including blaCMY-2, blaCTX-M-15, mph(A), erm(B), aac(6')-Ib-cr, qnrS1, aadA5, aadA1, aph(3')-Ic, aph(3')-Ia, aph(3')-Ib, aph(6')-Id, sul1, sul2, tet(A), and tet(B). Additionally, mutations in gyrA (S83L, D87N) and parC (A56T) were found to contribute to fluoroquinolone resistance.
Assessing bacterial diversity and antibiotic resistance dynamics in wastewater effluent-irrigated soil and vegetables in a microcosm setting.
The study identified the bla TEM gene as the only beta-lactam resistance gene in wastewater effluent, effluent-treated soil, and vegetables, highlighting the potential dissemination of antibiotic resistance genes through wastewater irrigation.
Carbapenem-Resistant Acinetobacter baumannii in U.S. Hospitals: Diversification of Circulating Lineages and Antimicrobial Resistance.
The study identifies multiple carbapenemase genes, including blaOXA-23 and blaOXA-207, as well as various resistance islands harboring genes such as aacA4, catB8, and armA, contributing to the multidrug resistance of CR Ab isolates in U.S. hospitals.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
The study identified multidrug-resistant Escherichia coli isolates from surface water in north-western Mexico, including international high-risk lineages ST410 and ST617. These isolates carried various AMR genes such as blaTEM-1B, blaCTX-M-15, aadA1, aadA2, aadA5, aac(3)-IIa, aac(3)-IId, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, floR, cmlA1, lnu(F), mdf(A), sul2, sul3, tet(A), tet(B), dfrA12, and dfrA17. Additionally, mutations in gyrA (S83L, D87N), parC (S80I), and parE (S458A) were found to contribute to fluoroquinolone resistance.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.
The report highlights the presence of various antimicrobial resistance genes such as blaVIM-1, blaTEM-1B, blaTEM-1C, and cfr in different bacterial isolates, indicating resistance to carbapenems, beta-lactams, and macrolides/lincosamides/streptogramin B.
The Current Landscape of Antibiotic Resistance of Salmonella Infantis in Italy: The Expansion of Extended-Spectrum Beta-Lactamase Producers on a Local Scale.
The study identified multiple antimicrobial resistance genes in Salmonella Infantis strains from Italy, including blaCTX-M-1, aadA1, dfrA1, dfrA14, sul1, and tet(A), which contribute to resistance against various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, sulfonamides, and tetracyclines.
Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).
The study identifies several AMR genes, including blaTEM-1, dfrA1, tetA, sul1, floR, aac(6')-laa, qnrE1, aadA1, and aac(6')-ly, in non-typhoidal Salmonella enterica strains. It also reports mutations in mgrB, pmrB, and pmrC associated with colistin resistance.
Multidrug Resistance Genes Carried by a Novel Transposon Tn7376 and a Genomic Island Named MMGI-4 in a Pathogenic Morganella morganii Isolate.
The study identifies a novel transposon Tn7376 and a genomic island MMGI-4 in a multidrug-resistant Morganella morganii isolate, carrying multiple antimicrobial resistance genes including dfrA24, mph(A), aadA1, sul1, floR, catA2, cmlA1, aph(3')-Ia, aac(6')-Ib-cr, tet(A), tet(B), arr-3, blaTEM-1B, blaDHA-17, blaCARB-2, blaOXA-1, blaCTX-M-3, and fosA3.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Epidemiology, Environmental Risks, Virulence, and Resistance Determinants of Klebsiella pneumoniae From Dairy Cows in Hubei, China.
The study identified several AMR genes in K. pneumoniae isolates from dairy cows in Hubei, China, including blaTEM, blaSHV, strA, strB, aadA1, and aac(6')-Ib-cr, which contribute to resistance against various antibiotics.
KPC-3-, GES-5-, and VIM-1-Producing Enterobacterales Isolated from Urban Ponds.
The study identified bla KPC-3, bla GES-5, and bla VIM genes in various Enterobacterales isolates from urban ponds, highlighting their role in carbapenem resistance.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Epidemiological investigation on drug resistance of Salmonella isolates from duck breeding farms in Shandong Province and surrounding areas, China.
The study identified 12 types of antibiotic resistance genes in 110 Salmonella isolates from duck farms in Shandong Province, China, including beta-lactam, aminoglycoside, tetracycline, macrolide, and quinolone resistance genes. The most prevalent resistance genes were blaTEM, aac(6')-Ib-cr, and tetA. The study also found that class I integrons and plasmids play a significant role in the dissemination of these resistance genes.
GR13-type plasmids in Acinetobacter potentiate the accumulation and horizontal transfer of diverse accessory genes.
The study identifies multiple antibiotic resistance genes, including bla OXA-58, bla NDM-1, ble MBL, sul2, aacC2d, msr(E)-mph(E), and tet(B), in GR13-type plasmids from Acinetobacter isolates, highlighting their role in multidrug resistance and horizontal gene transfer.
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
Genomic Analysis of Two MDR Isolates of Salmonella enterica Serovar Infantis from a Spanish Hospital Bearing the bla(CTX-M-65) Gene with or without fosA3 in pESI-like Plasmids.
The study reports two multidrug-resistant (MDR) isolates of Salmonella enterica serovar Infantis from Spain carrying the blaCTX-M-65 gene on pESI-like plasmids, along with other resistance genes such as floR, aac(3)-IVa, aph(3′)-Ia, aph(4)-Ia, aadA1, tet(A), sul1, dfrA14, and fosA3. Mutations in gyrA and parC were associated with fluoroquinolone resistance, while truncations in nsfA and nsfB were linked to nitrofurantoin resistance.
Longitudinal study on background lesions in broiler breeder flocks and their progeny, and genomic characterisation of Escherichia coli.
The study identified several AMR genes in E. coli isolates, including mdfA, sitABCD, blaTEM1B, sul2, dfrA1, tet(A), aadA1, and qnrS1, which conferred resistance to multidrug, beta-lactams, sulfonamides, trimethoprim, tetracycline, aminoglycosides, and quinolones.
Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients.
The study characterizes the bla NDM-5 gene in multidrug-resistant commensal E. coli from diarrheal patients, highlighting its resistance to various antibiotics and its potential for horizontal transfer.
Genome Analysis of ESBL-Producing Escherichia coli Isolated from Pigs.
The study identified several AMR genes in ESBL-producing E. coli isolates from pigs, including blaCTX-M-15, aminoglycoside resistance genes, qnrS1, and mcr-1, highlighting the presence of multidrug-resistant strains with potential implications for human health.
Antibiotic resistance genes of public health importance in livestock and humans in an informal urban community in Nepal.
The study identified several antibiotic resistance genes, including bla SHV-1, QnrS, ermC, tetA, tetB, aacC2, and aadA1, in various sources such as humans, animals, and water in an urban informal settlement in Nepal.
Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa.
The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
Identification and Characterisation of pST1023 A Mosaic, Multidrug-Resistant and Mobilisable IncR Plasmid.
The study identifies and characterizes the mosaic, multidrug-resistant, and mobilizable IncR plasmid pST1023, which carries several AMR genes including cmlA1, aadA1, aadA2, sul3, tetA(B), dfrA12, and a sil operon conferring resistance to various antibiotics and silver.
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-15, and bla OXA-1 genes in ESBL- and AmpC-producing E. coli isolates from New Zealand dairy farms, highlighting the presence of plasmid-mediated resistance mechanisms.
Genomic Analysis of Shiga Toxin-Producing E. coli O157 Cattle and Clinical Isolates from Alberta, Canada.
The study identified eight antimicrobial resistance gene cassettes (ARCs) in 14 isolates, with streptomycin resistance genes (aadA1, aadA2, ant(3'')-Ia, and aph(3'')-Ib) being the most prevalent. Other resistance genes included sul1, sul2, tet(A), tet(B), and beta-lactam resistance genes (blaTEM-1B and blaTEM-1C).
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China.
The study identifies the emergence of an extensively drug-resistant Citrobacter portucalensis strain, K218, which carries multiple resistance genes including bla KPC-2 and bla NDM-1, contributing to its multidrug-resistant phenotype.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
A One Health Genomic Investigation of Gentamicin Resistance in Escherichia coli from Human and Chicken Sources in Canada, 2014 to 2017.
The study identified several aminoglycoside-modifying enzymes, including aac(3)-IId, aac(3)-VIa, aac(3)-IIa, aac(6′)-Ib-cr, aac(3)-IVa, ant(2″)-Ia, aadA5, aadA1, aadA2, aph(3″)-Ib, and strA, as key contributors to gentamicin and spectinomycin resistance in Escherichia coli from human and chicken sources in Canada.
Three Distinct Annotation Platforms Differ in Detection of Antimicrobial Resistance Genes in Long-Read, Short-Read, and Hybrid Sequences Derived from Total Genomic DNA or from Purified Plasmid DNA.
The study compared different annotation platforms for detecting antimicrobial resistance (AMR) genes in various sequencing data types. It found that plasmid DNA purification was unnecessary for detecting plasmid-borne AMR genes and that hybrid sequencing improved AMR gene detection. The study also highlighted variations in AMR gene detection among different databases.
Genomic Characterization of an Extensively Drug-Resistant Extra-Intestinal Pathogenic (ExPEC) Escherichia coli Clinical Isolate Co-Producing Two Carbapenemases and a 16S rRNA Methylase.
The study describes an extensively drug-resistant (XDR) E. coli ST361 isolate co-carrying bla KPC-3, bla NDM-5, and various other resistance genes on multiple plasmids, showing resistance to nearly all antibiotics except tigecycline, colistin, and fosfomycin.
A First Report of Molecular Typing, Virulence Traits, and Phenotypic and Genotypic Resistance Patterns of Newly Emerging XDR and MDR Aeromonas veronii in Mugil seheli.
The study identified XDR and MDR Aeromonas veronii strains in Mugil seheli carrying resistance genes bla TEM, bla CTX-M, bla SHV, tet A, aad A1, and sul 1.
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
Genomic landscape of prominent XDR Acinetobacter clonal complexes from Dhaka, Bangladesh.
The study identified multiple beta-lactamase genes, including bla OXA-23, bla OXA-66, bla NDM-1, and others, as well as aminoglycoside resistance genes such as aac(3)-Ia, aadA1, and dfrA1, which contribute to the extensive drug resistance in Acinetobacter strains from Bangladesh.
Isolation, Identification and Genetic Characterization of Antibiotic Resistant Escherichia coli from Frozen Chicken Meat Obtained from Supermarkets at Dhaka City in Bangladesh.
The study identified several antimicrobial resistance genes in E. coli isolates from frozen chicken meat, including tet(A), tet(B), aadA1, aac(3)-IV, ereA, blaCITM, blaSHV, sulI, catA1, and cmlA, which confer resistance to tetracycline, streptomycin, gentamicin, erythromycin, ampicillin, sulfonamide, and chloramphenicol.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Epidemiology and Genetic Characteristics of Carbapenem-Resistant Escherichia coli in Chinese Intensive Care Unit Analyzed by Whole-Genome Sequencing: a Prospective Observational Study.
The study identified bla KPC-2 and bla NDM-5 as the main carbapenem resistance genes in carbapenem-resistant Escherichia coli (CREC) isolates. Additionally, various other resistance genes were detected, including extended-spectrum beta-lactamases (CTX-M-14, CTX-M-15, CTX-M-27, CTX-M-3, OXA-1, OXA-10, TEM-1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-Iva, aac(6′)-Ib-AKT, aac(6′)-Ib-D181Y, aadA1, aadA2, aadA5, aph(3″)-Ib, aph(3′)-Ia, aph(4)-Ia, aph(6)-Id), quinolone resistance genes (qnrS1, qnrS2), tetracycline resistance genes (oqxA10, oqxB17), fosfomycin resistance gene (fosA3), and chloramphenicol resistance genes (cmlA1, cmlA5).
oprL Gene Sequencing, Resistance Patterns, Virulence Genes, Quorum Sensing and Antibiotic Resistance Genes of XDR Pseudomonas aeruginosa Isolated from Broiler Chickens.
The study identified XDR P. aeruginosa strains from broiler chickens in Egypt, which harbor multiple antibiotic resistance genes including bla TEM, bla CTX-M, bla OXA-1, aad A1, tet A, and sul 1. These strains showed resistance to multiple antimicrobial classes.
Genetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection.
The study identified multiple acquired antimicrobial resistance genes and resistance-mediating mutations in a Gallibacterium anatis isolate from a calf with a respiratory tract infection, highlighting the potential for this bacterium to serve as a reservoir for antimicrobial resistance genes.
Analysis of Antimicrobial Resistance Genes (ARGs) in Enterobacterales and A. baumannii Clinical Strains Colonizing a Single Italian Patient.
The study identified various antimicrobial resistance genes in Enterobacterales and A. baumannii clinical strains from a single patient, highlighting the presence of blaNDM-1, qnrS1, aadA1, strA-strB, sul2, tet(J), catA1, blaACT-15, blaTEM-1B, dfrA14, oqxB, fosA, blaLEN-22, blaOXA-23, blaADC-25, blaOXA-66, armA, mph(E), msr(E), and tetB, indicating multidrug resistance and potential for horizontal gene transfer.
Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation.
The study identified multiple AMR genes and efflux pump systems in P. aeruginosa persister isolates, highlighting their multidrug-resistant phenotype and biofilm-forming capabilities.
The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China.
The study identifies multiple antimicrobial resistance genes in Salmonella enterica isolates from China, highlighting the increasing prevalence of resistance to beta-lactams, quinolones, tetracyclines, and sulfonamides. Key genes include blaTEM-1B, blaCTX-M-14, aac(3)-IV, and mcr-1.
Prevalence and Genomic Characteristics of mcr-Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China.
The study identified mcr-1 as a major gene conferring colistin resistance in Escherichia coli isolates from humans, pigs, and foods in China. Additionally, several other resistance genes such as tet(A), floR, sul2, aadA1, strA, strB, blaCTX-M-14, fosA, lnu(F), and arr-3 were found to confer resistance to various antibiotics.
Potential Use of a Combined Bacteriophage-Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study.
The study evaluated the effectiveness of a combined probiotic-phage sanitation system (PCHSφ) in reducing microbial contamination and antimicrobial resistance (AMR) in hospital environments. PCHSφ significantly reduced staphylococcal contamination and AMR gene prevalence compared to conventional chemical disinfection and PCHS alone.
High Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Isolates Recovered in Nigerian Hospitals in 2016 to 2020.
The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.
Analysis of antibiotic resistance gene cassettes in a newly identified Salmonella enterica serovar Gallinarum strain in Korea.
The study identifies the presence of aadA1 and sul1 resistance genes in Salmonella enterica serovar Gallinarum strain SG4021. However, the insertion of ISCR16 downstream of the sul1 promoter leads to reduced expression of sul1, resulting in sulfonamide sensitivity despite the presence of the gene.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Pathogen genomics and phage-based solutions for accurately identifying and controlling Salmonella pathogens.
The study identified various AMR genes in Salmonella isolates from the UK and Thailand, highlighting the prevalence of resistance to multiple antibiotics, particularly in certain serovars like S. Typhimurium and S. 1,4,[5],12:i:-. Key AMR genes included bla TEM-1b, bla CARB-2, bla TEM-135, bla TEM-1D, mphB, cmlA1, floR, gyrA, qnrS1, aac(3)-Id, aac(3)-IVa, strA, strB, sul1, sul2, sul3, tetA(B), tet(A), tet(G), tet(M), and dfrA12.
Whole-genome sequencing and phylogenetic analysis capture the emergence of a multi-drug resistant Salmonella enterica serovar Infantis clone from diagnostic animal samples in the United States.
The study identifies a multidrug-resistant Salmonella infantis clone harboring a pESI-like megaplasmid with the blaCTX-M-65 gene, which confers resistance to ceftriaxone and ampicillin. Several other AMR genes, including aac(3)-IVa, aadA1, aph(4)-Ia, sul1, tetA, floR, dfrA14, and fosA, were also characterized.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
Growth in a biofilm promotes conjugation of a bla (NDM-1)-bearing plasmid between Klebsiella pneumoniae strains.
The study identifies the bla NDM-1 gene on the plasmid pCPE16_3 as a key contributor to carbapenem resistance in Klebsiella pneumoniae, demonstrating that biofilm growth enhances the conjugative transfer of this plasmid.
A national study confirms that Escherichia coli from Australian commercial layer hens remain susceptible to critically important antimicrobials.
The study found that Escherichia coli from Australian commercial layer hens show low rates of antimicrobial resistance, with most isolates susceptible to all tested antimicrobials. Resistance was observed for several antibiotics, including tetracycline, ampicillin, and ciprofloxacin, but no resistance to critical antimicrobials like colistin. Whole genome sequencing identified various AMR genes such as aadA1, dfrA1, strA, strB, sul1, sul2, tet(A), lnu(C), blaTEM-1B, and qnrS1.
On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective.
The study identifies several AMR genes and mutations associated with streptomycin, kasugamycin, gentamicin, and oxytetracycline resistance in plant pathogenic bacteria, highlighting the role of Tn 5393 and other mobile genetic elements in the dissemination of these resistance traits.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Occurrence of ESBL- and AmpC-Producing E. coli in French Griffon Vultures Feeding on Extensive Livestock Carcasses.
The study identified ESBL-producing E. coli carrying the bla CTX-M-15 gene in French griffon vultures, highlighting the spread of multidrug-resistant bacteria through scavenging behavior.
Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.
The study identified various AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Alexandria, Egypt, including bla OXA-51-like variants, bla OXA-23, bla NDM-1, bla PER-7, bla GES-like, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, tetracyclines, and other antibiotics.
High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China.
The study identified a high rate of multidrug resistance in E. coli isolates from diseased ducks in China, with several AMR genes such as bla TEM, bla CTX-M, qnrS, aadA1, sul1, sul2, tet A, floR, mcr-1, intI1, and intI2 being characterized.
Isolation and characterization of multidrug resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens.
The study identified 25 different antimicrobial resistance genes in multidrug-resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens, including tetB, blaTEM-1, blaROB-1, floR, sul2, sul3, dfrK, aadA1, aadA2, aph(3)-la, aph(3)-lb, aph(6)-ld, sat2, dfrA14, dfrA32, merC, merP, merR, merT, qacL, and cmlA1.
Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves.
The study identifies multiple antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) co-localized on plasmids in Klebsiella pneumoniae isolated from marine bivalves, highlighting the potential for co-selection of these genes in the marine environment.
Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales.
The study identified 10 variants of the intrinsic beta-lactamase gene blaOXY-2 in clinical Klebsiella oxytoca isolates, which confer resistance to penicillins. Additionally, two novel blaOXY-2 variants (blaOXY-2-35 and blaOXY-2-36) were discovered.
Comparative Genomics Reveals Novel Species and Insights into the Biotechnological Potential, Virulence, and Resistance of Alcaligenes.
The study identifies multiple antimicrobial resistance genes in Alcaligenes species, particularly in clinical isolates, highlighting the presence of genes conferring resistance to β-lactams, aminoglycosides, sulfonamides, and other antibiotics.
Protistan predation selects for antibiotic resistance in soil bacterial communities.
The study found that increasing protistan predation pressure significantly enhances the abundance and diversity of antibiotic resistance genes (ARGs) in soil bacterial communities, particularly multidrug efflux pump genes (oprJ, ttgB), tetracycline efflux pump gene (tetV), aminoglycoside resistance gene (aadA1), beta-lactamase genes (blaTEM, ampC-04), and glycopeptide resistance genes (vanWG, vanC-03).
Extensive Expression of the Virulome Related to Antibiotic Genotyping in Nosocomial Strains of Klebsiella pneumoniae.
The study identified several antibiotic resistance genes in multidrug-resistant Klebsiella pneumoniae strains, including beta-lactamases (bla TEM, bla SHV, bla CITM, bla CTXM-1), tetracycline resistance (tetA), sulfonamide resistance (sul1), aminoglycoside resistance (aac(3)-IV, aadA1), and others.
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Characterization of integrons, extended spectrum beta lactamases and genetic diversity among uropathogenic Escherichia coli isolates from Kerman, south east of Iran.
The study identified the presence of class I integrons and ESBLs, particularly bla CTX-M, bla TEM, and bla SHV, in uropathogenic E. coli isolates from Kerman, Iran. Additionally, various gene cassettes such as dfrA17-aadA5, aadA1-dfrA1, and others were detected, contributing to resistance against multiple antibiotics.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
A One Health approach based on genomics for enhancing the Salmonella enterica surveillance in Colombia.
The study identified various AMR genes in Salmonella enterica serovars, including qnrB81, aph_6, sul2, tetA, blaCMY_2, qnrB19, aac_3_IV, blaLEN_15, aph4_la, aadA1, blaTEM_95, qnrB82, and mcr-5.1, which confer resistance to quinolones, aminoglycosides, sulfonamides, tetracyclines, beta-lactams, and colistin.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance.
The study identified multiple antimicrobial resistance genes and mutations in Shigella isolates from Lebanon, including bla CTX-M-15 and bla CTX-M-3 for extended-spectrum beta-lactamase resistance, and gyrA mutations for quinolone resistance.
Tracing the Evolutionary Pathways of Serogroup O78 Avian Pathogenic Escherichia coli.
The study characterizes the AMR genes and mutations in O78 APEC strains, highlighting the presence of resistance genes such as blaTEM, blaSHV, blaCTX-M, ampC, tetB, tetA, sul1, sul2, dfrA1, aadA, aac(3)II, strA/strB, and floR, indicating multidrug resistance in these strains.
Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina.
The study identified several AMR genes in E. coli isolates from retail meat products in North Carolina, including aac(3)-IV, aadA1, aph(3'')-lb, blaTEM-1, tetB, and others, highlighting the prevalence of multidrug-resistant E. coli in ground turkey.
Genomic Features of an MDR Escherichia coli ST5506 Harboring an IncHI2/In229/bla(CTX-M-2) Array Isolated from a Migratory Black Skimmer.
An MDR E. coli ST5506 strain was isolated from a migratory black skimmer, harboring a complex array including bla(CTX-M-2), bla(TEM-1C), aac(3)-VIa, aadA1, aph(3′)-Ia, sul1, dfrA27, and tetA, indicating resistance to various antimicrobials.
Plasmid content of carbapenem resistant Acinetobacter baumannii isolates belonging to five International Clones collected from hospitals of Alexandria, Egypt.
The study characterizes various AMR genes in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaPER-7, blaGES-11, blaGES-35, aph(3')-VI, aac(6')-Ib, sul1, sul2, mph(E), msr(E), armA, strA, strB, cmlA5, arr-2, ant(3'')-II, aadA1-pm, tet(B), tet(39), qacEΔ1, and dfrA7.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
The study identified several AMR genes and mutations in Salmonella enterica subsp. enterica serovar Enteritidis isolates from human and non-human sources in Portugal, including blaTEM-1A, blaTEM-1B, blaCMY-2, aac(6')-Iaa, sul1, and aaDA1, as well as mutations in gyrA associated with fluoroquinolone resistance.
Genomic Surveillance Uncovers a 10-Year Persistence of an OXA-24/40 Acinetobacter baumannii Clone in a Tertiary Hospital in Northern Spain.
The study identifies the persistence of an OXA-24/40 Acinetobacter baumannii clone over 10 years in a Spanish hospital, highlighting the role of the bla OXA-24/40 gene and a novel variant, bla OXA-1040, in carbapenem resistance. It also characterizes other resistance genes such as aad A1, aph (3')-VIa-like, str A, str B, sul1, sul2, and tet(B)-like, contributing to multidrug resistance.
Genomic Features and Phylogenetic Analysis of Antimicrobial-Resistant Salmonella Mbandaka ST413 Strains.
The study identified nine resistance genes, including aac(6')-Iaa, sul1, qacE, blaOXA-129, tet(B), and aadA1, as well as a point mutation in ParC (T57S) associated with quinolone resistance in Salmonella Mbandaka ST413 strains.
Prevalence and molecular characterization of multi-resistant Escherichia coli isolates from clinical bovine mastitis in China.
The study identified multiple AMR genes and mutations in E. coli isolates from bovine mastitis, including blaTEM, blaCTX, dfrA1, dfrA1-aadA1, dfrA1-catB2-aadA1, dfrA17-aadA5, aadA1, aadA5, catB2, catB3, and mutations in gyrA, parC, gyrB, and parE associated with fluoroquinolone resistance.
Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic.
The study identified high prevalence of carbapenem resistance in Gram-negative pathogens in Egypt, with bla NDM and bla OXA-48-like being the most prevalent carbapenemase genes. Plasmid-mediated quinolone resistance genes qnrS and qnrB were also detected. Additionally, several aminoglycoside resistance genes and integron-associated gene cassettes were characterized.
Activity of Epsilon-poly-L-lysine against Multidrug-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates of Urinary Tract Infections.
The study identified various beta-lactamase genes, including blaSPM, blaKPC, blaSHV, blaCTX-M, blaOXA, blaTEM, blaPER, blaVIM, and blaVIM-2 in Pseudomonas aeruginosa, and blaCTX-M, blaTEM, blaKPC, blaNDM, and blaOXA in Klebsiella pneumoniae. Additionally, aac(3)-IV, aadA1, aac(3)-II, sul2, sul1, sul3, dfrA, cmlA, and tetA were found to confer resistance to aminoglycosides, sulfonamides, trimethoprim, chloramphenicol, and tetracyclines.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Klebsiella pneumoniae sequence type 147: a high-risk clone increasingly associated with plasmids carrying both resistance and virulence elements.
The study identified various AMR genes and mutations in Klebsiella pneumoniae ST147 isolates, including bla NDM-5, bla NDM-1, bla OXA-181, bla OXA-232, bla OXA-48, aadA1, aph(3')-VI, bla CTX-M-15, bla TEM-1B/C, bla OXA-9, truncated catA1, qnrS1, sul1, dfrA5, mph(A), erm(B), aac(6')-Ib, aac(6')-Ib3, sul2, aph(3')-Ia, rmtB, fosA, oqxAB, bla SHV-11/67, arr-3, and catB3.
Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China.
The study identified multiple antimicrobial resistance genes in Avibacterium paragallinarum isolates from Guangdong, China, including tet(B), aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aad-A, sul2, sul3, catP, floR, blaOXA-1, blaCTX-M-14, erm(X), mef(B), and fosA3. These genes were associated with resistance to tetracycline, streptomycin, kanamycin, trimethoprim-sulfamethoxazole, chloramphenicol, ampicillin, erythromycin, and fosfomycin.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Green Synthesized Chitosan Nanoparticles for Controlling Multidrug-Resistant mecA- and blaZ-Positive Staphylococcus aureus and aadA1-Positive Escherichia coli.
The study identifies mecA, blaZ, and aadA1 as resistance genes in multidrug-resistant Staphylococcus aureus and Escherichia coli, demonstrating the efficacy of chitosan nanoparticles against these pathogens.
Molecular basis of the persistence of chloramphenicol resistance among Escherichia coli and Salmonella spp. from pigs, pork and humans in Thailand.
The study identifies catA and cmlA as the primary genes responsible for chloramphenicol resistance in E. coli and Salmonella isolates from Thailand, highlighting their persistence through co-selection and horizontal gene transfer.
Molecular Characterization of Resistance and Virulence Factors of Trueperella pyogenes Isolated from Clinical Bovine Mastitis Cases in China.
The study identified aadA9, tetW, ermX, aadA1, aadA11, strA-strB, and aadB as key AMR genes in T. pyogenes isolates from bovine mastitis in China, highlighting high resistance to streptomycin and tetracycline.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
A panel of genotypically and phenotypically diverse clinical Acinetobacter baumannii strains for novel antibiotic development.
The study identifies various AMR genes and mutations in a diverse panel of Acinetobacter baumannii strains, including bla OXA-23, bla OXA-24, bla OXA-58, bla NDM-1, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Metagenome-wide characterization of shared antimicrobial resistance genes in sympatric people and lemurs in rural Madagascar.
The study identified five tetracycline resistance genes (tet(32), tet(40), tet(W), tet(Q)) and one trimethoprim resistance gene (dfrF) that were significantly more abundant in human microbiomes compared to lemur microbiomes. These genes were found to be highly conserved between human and lemur microbiomes.
Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands.
The study identifies the NDM-1-producing Pseudomonas aeruginosa ST357 as an extensively drug-resistant strain with a unique resistome, highlighting the importance of tracking the origin of such isolates through genomic epidemiology.
The synergy effect of matrine and berberine hydrochloride on treating colibacillosis caused by an avian highly pathogenic multidrug-resistant Escherichia coli.
The study identified multiple antibiotic resistance genes in a multidrug-resistant Escherichia coli strain, including blaTEM, ermA, ermB, aadA1, qnrS, qepA, oqxA, tetA, tetB, and tetC, which conferred resistance to various antibiotics such as beta-lactams, macrolides, aminoglycosides, quinolones, and tetracyclines. The combination of matrine and berberine hydrochloride showed synergistic antibacterial effects against this strain.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
Characterization of the carbapenem-resistant Acinetobacter baumannii clinical reference isolate BAL062 (CC2:KL58:OCL1): resistance properties and capsular polysaccharide structure.
The study characterizes the carbapenem-resistant Acinetobacter baumannii isolate BAL062, identifying resistance genes such as oxa23, ampC, strA-strB, tet(B), sul1, aadA1, and aacC1. It also reveals that BAL062 has lost certain resistance genes, resulting in susceptibility to amikacin, tobramycin, and kanamycin.
Assessment of the presence of multidrug-resistant Escherichia coli, Salmonella and Staphylococcus in chicken meat, eggs and faeces in Mymensingh division of Bangladesh.
The study identified multiple AMR genes in E. coli, Salmonella spp., and Staphylococcus aureus isolated from chicken meat, eggs, and faeces in Bangladesh, highlighting the presence of multidrug-resistant pathogens.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Whole-genome sequencing of Klebsiella pneumoniae MDR circulating in a pediatric hospital setting: a comprehensive genome analysis of isolates from Guayaquil, Ecuador.
The study identified several AMR genes and mutations in K. pneumoniae isolates from Ecuador, including bla KPC-3, bla OXA-9, aadA1, aac(6')-Ib-AKT, and mutations in ompK35, ompK36, ompK37, gyrA, parC, and acrR, contributing to resistance against beta-lactams, aminoglycosides, fluoroquinolones, and other antibiotics.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Natural compound-induced downregulation of antimicrobial resistance and biofilm-linked genes in wastewater Aeromonas species.
The study identifies aadA1, aadA2, and sul1 as antimicrobial resistance genes in wastewater Aeromonas species, which are downregulated by natural compounds.
Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
The study identified multiple AMR genes and mutations in multidrug-resistant Shigella strains, including beta-lactamases, macrolide resistance genes, quinolone resistance genes, and chromosomal mutations contributing to fluoroquinolone resistance.
Genomic perspective on the bacillus causing paratyphoid B fever.
The study identified mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones in Salmonella enterica serotype paratyphi B strains.
Exploring the genomic and antimicrobial resistance tapestry: comparative insights into Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama in Latin American surface waters.
The study identifies several AMR genes, including fosA7.2, qnrB19, aadA1, floR, sat2, tet(B), and tet(A), in Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama from Latin American surface waters, highlighting the prevalence of multidrug resistance in these isolates.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.
The study identified multiple antibiotic resistance genes in E. coli isolates from raw milk in Gujarat, India, including beta-lactamases, quinolone resistance genes, efflux pumps, folate pathway antagonists, aminoglycoside resistance genes, and tetracycline resistance genes.
Characterization of Klebsiella pneumoniae Isolates Resistant to Cefiderocol from Hospitals and Outpatient Settings in Croatia.
The study characterizes AMR genes in FDC-resistant K. pneumoniae isolates, identifying bla OXA-48, bla KPC, bla NDM, bla CTX-M, aac(6')-Ib, aadA1, aadA2, qnrB, shv, and tem as significant contributors to resistance.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli.
The study identified various AMR genes and mutations in AmpC/ESBL-producing E. coli from wastewater samples in Finland, highlighting the prevalence of blaCTX-M-15, blaCTX-M-27, and other resistance determinants.
Broiler litter moisture and trace metals contribute to the persistence of Salmonella strains that harbor large plasmids carrying siderophores.
The study identified several antimicrobial resistance genes in Salmonella strains isolated from broiler litter, including aadA1, aac(3)-IV, aph(3′)-Ia, aph(4)-Ia, dfrA14, floR, sul1, tetA, sul2, merRTPCA, qacE, aph(3″)-Ib, aph(6)-Id, pcoABCDRE, silP, and silE. These genes were found on various plasmids and contributed to resistance against multiple antibiotics such as streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, mercury, quaternary ammonium compounds, copper, and silver.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019-2021).
The study identified a variety of antimicrobial resistance genes in clinical Klebsiella pneumoniae species complex isolates, including bla KPC−2, bla CTX−M, bla SHV, aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, oqxAB, qnrB19, qnrS1, tet(A), tet(D), sul1, sul2, sul3, cmlA1, floR, fosA, and fosA3. These genes confer resistance to multiple classes of antibiotics, highlighting the complexity of antimicrobial resistance in these isolates.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
Inhibitory effects of benzyl isothiocyanate on widespread mcr-1-harbouring IncX4 plasmid transfer.
The study characterizes the presence of mcr-1.1, mcr-3.5, blaCTX-M-55, and tet(X4) genes in clinical isolates of Enterobacterales from Thailand, highlighting their role in multidrug resistance and the potential for horizontal gene transfer.
Genome-Based Molecular Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
AmrProfiler: A Comprehensive Tool for Antimicrobial Resistance Gene Detection and Analysis
AmrProfiler identifies a wide range of AMR genes and mutations across multiple bacterial species, demonstrating high accuracy and broader species coverage compared to existing tools.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Emergence and characteristics of multidrug-resistant Salmonella enterica subspecies enterica serovar Infantis harboring the pESI plasmid in chicken slaughterhouses in South Korea.
The study identifies multidrug-resistant Salmonella enterica subsp. enterica serovar Infantis isolates harboring the pESI plasmid, which carries genes such as bla CTX-M-65, aadA1, dfrA14, sul1, tetA, and floR, leading to resistance against multiple antibiotics including third-generation cephalosporins.
Local Genomic Epidemiology of Acinetobacter baumannii Circulating in Hospital and Non-hospital Environments in Kano, Northwest Nigeria.
The study identifies various AMR genes in Acinetobacter baumannii isolates from hospital and non-hospital environments in Kano, Nigeria, including bla OXA-66, bla OXA-180, bla ADC-25, aadA1, aph(3')-Ia, aph(3'' )-Ib, aac(3)-Ia, aph(6)-Id, tetB, sul1, and sul2, which confer resistance to beta-lactams, aminoglycosides, tetracyclines, and sulfonamides.
Retrospective analysis of antimicrobial resistance of Salmonella spp. isolated from livestock and its environment in Thailand.
The study identified several AMR genes in Salmonella isolates from livestock and their environment in Thailand, including aadA1, aadA2, aadB, aac(6')-Ia, blaTEM, tetA, tetB, catA, catB, cmlA, sulI, and dfrA1, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, chloramphenicol, sulfamethoxazole, and trimethoprim.
Occurrence and Drivers of Antibiotic Resistance Genes Carried by Bacteriophages in Soils Following Different Fertilization Treatments.
The study identified 19 pARG subtypes in soils with different fertilization treatments, highlighting the impact of organic fertilizers on the diversity and abundance of antibiotic resistance genes carried by bacteriophages.
Genomic insights into multidrug - resistant Salmonella enterica isolates from pet dogs and cats.
The study identified multiple AMR genes in multidrug-resistant Salmonella enterica isolates from pet dogs and cats, including aac(6')-Iaa, aadA1, aadA2, blaTEM-1B, qacL, sul3, tet(A), qnrS1, fosA7, dfrA12, cmlA1, aph(3')-Ib, aph(6)-Id, blaCTX-M-55, blaTEM-215, and floR, which confer resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole, ciprofloxacin, and chloramphenicol.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Pan-drug, colistin, streptomycin, erythromycin, clindamycin resistant Salmonella enterica serovars isolated from slaughtered cattle and human in mansoura, Egypt.
The study identified multiple AMR genes in Salmonella isolates, including aadA1, tetA, sul1, and aac(3)-IV, which conferred resistance to streptomycin, tetracycline, sulfamethoxazole/trimethoprim, and gentamicin, respectively.
Taxonomic and phenotypic characterization of a novel Providencia species: Providencia lanzhouensis sp. nov.
The study identifies Providencia lanzhouensis sp. nov., a novel species with multiple antimicrobial resistance genes, including aadA1, aadA2, aph(6)-Id, aph(3'')-Ib, aph(3')-Ia, sat2, sul2, ere(A), dfrA32, floR, tetC, and qnrD1, which confer resistance to aminoglycosides, streptomycin, sulfonamides, macrolides, trimethoprim, phenicols, tetracyclines, and quinolones.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars detected in poultry retail meat in North Carolina, USA.
The study identifies the clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars in poultry retail meat in North Carolina, USA. It characterizes the resistance profiles of these isolates, including the presence of bla(CTX-M-65), aac(3)-Iva, aadA1, aph(4)-Ia, floR, mdsA, mdsB, sul1, tet(A), dfrA14, aph(3')-Ia, sul2, aph(3'')-Ib, and fosA3.
Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.
The paper discusses the identification of various AMR genes in Acinetobacter baumannii and other pathogens, highlighting their role in resistance to multiple antibiotics and the potential of phage therapy as an alternative treatment.
Prevalence, Risk Factors, and Human Health Implications of Salmonella enterica and Campylobacter spp. in Vermont Backyard Poultry.
The study identified various AMR genes and mutations in Salmonella enterica isolates from Vermont backyard poultry, highlighting resistance to streptomycin, tetracycline, sulfonamides, and ampicillin, as well as quinolone resistance through specific mutations.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb.
The study reports an outbreak of carbapenem-resistant Proteus mirabilis in a psychiatric hospital in Zagreb, Croatia, characterized by the presence of VIM-1 and VIM-4 carbapenemases, along with other resistance genes such as bla CTX-M-15, bla TEM, and aminoglycoside resistance genes.
Molecular epidemiology of pESI-carrying Salmonella Infantis in Korea: insights from a one health framework.
The study identifies multiple antimicrobial resistance genes and a quinolone resistance mutation in pESI-carrying Salmonella Infantis isolates from the Korean poultry production chain, highlighting the potential for zoonotic transmission.
Characterization of Aeromonas hydrophila isolated from freshwater fish with control trial.
The study identified the presence of the bla TEM gene, which confers resistance to beta-lactam antibiotics, and the aadA1 gene, which confers resistance to streptomycin, in Aeromonas hydrophila isolates from freshwater fish in Egypt.
Phenotypic and Molecular Study of Multidrug-Resistant Escherichia coli Isolates Expressing Diverse Resistance and Virulence Genes from Broilers in Tunisia.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from broilers in Tunisia, including bla CTX-M-G1, bla TEM, bla SHV, bla OXA-48, bla IMP, mcr-1, aadA-1, aadA-5, aac(6)-Ib-cr, qnrS, and qnrB.
Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020-2023.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Molecular characterization of drug-resistance genes and dynamics of multidrug-resistant Salmonella spp. in waterfowl: a pre- and post-antibiotic ban surveillance in Guangdong, China from 2013 to 2023.
The study identified several AMR genes in Salmonella isolates from waterfowl in Guangdong, China, including bla CTX-M, bla TEM, bla OXA, aad A1, aad A2, aac C2, aac (3)-IV, aph (3’)-I, qnr A, qnr S, clm A, flo R, tet (A), and Sul II. These genes were associated with resistance to various antibiotics such as β-lactams, aminoglycosides, quinolones, chloramphenicol, tetracyclines, and sulfonamides.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Antibiotic resistance and pathogenicity of Shiga-toxin-producing Escherichia coli (STEC) and non-STEC isolated from goats in the Mekong Delta, Vietnam.
The study identified several antibiotic resistance genes, including blaampC, tetA, sulII, qnrA, aadA1, and czcD, in E. coli isolates from goats in the Mekong Delta, Vietnam. It also detected virulent genes such as stx1, stx2, eae, and hlyA.
The transferable resistome of biosolids-plasmid sequencing reveals carriage of clinically relevant antibiotic resistance genes.
The study identified various antibiotic resistance genes (ARGs) carried by plasmids isolated from biosolids, highlighting the role of wastewater treatment plants (WWTPs) as hotspots for horizontal gene transfer of clinically relevant resistance genes.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Genetic diversity and antimicrobial resistance profiles of Salmonella enterica in the broiler supply chain in Harare, Zimbabwe: tracking transmission from farm to table.
The study identified several AMR genes and mutations in Salmonella enterica isolates from the broiler supply chain in Zimbabwe, including fosA7.2, qnrB19, aadA1, aph(3'')-Ib, aph(6)-Id, aac(3)-Id, fosA3, sul1, sul3, tetA, cmlA1, blaCMY-2, blaTEM-1B, blaCTX-M-14, and mutations in gyrA and parC. These genes and mutations confer resistance to various antibiotics, including fosfomycin, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, and beta-lactams.
Escherichia coli O157:H7 prevalence in Upper Egypt: impacts on food safety and human Health, with a protection trial using natural antibacterial Piper cubeba.
The study identified blaTEM, tetA, and Aada1 as the most common resistance genes in multidrug-resistant E. coli O157:H7 isolates in Upper Egypt. These genes confer resistance to beta-lactams, tetracyclines, and aminoglycosides, respectively.
Integrated Analysis of Salmonella Infantis in Chicken Meat: Epidemiological Surveillance, Antibiotic Resistance, and Potential Bioactive Control Agents.
The study identified multiple antibiotic resistance genes in Salmonella Infantis isolates from chicken meat, including blaTEM-1, aadA1, aphA1-IAB, and sul1, indicating multidrug resistance. Carvacrol showed the strongest antimicrobial activity against these isolates.
Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance.
The study identified a high prevalence of trimethoprim resistance genes (dfrA1, dfrA15, dfrA31) and other resistance genes such as floR, strA, strB, varG, blaCARB-2, aadA1, aadA2, sul1, sul2, catB9, tet(C), tet(G), tet(59), qacEdelta, and blaCMY-4 in Vibrio cholerae isolates from Africa. Fluoroquinolone resistance mutations (gyrA_S83I and parC_S85L) and nitrofuran resistance mutations (nfsA_R169C and nfsB_Q5*) were also prevalent.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Virulence profiles and antibiotic resistance patterns of Escherichia coli isolated from clinical samples and chicken meat: Implications for public health and food safety.
The study identified several antibiotic resistance genes in E. coli isolates from clinical and chicken meat samples, including ermA, tetM, blaTEM, qnrS, and aadA1, highlighting the prevalence of multidrug resistance and the potential public health risks associated with contaminated food sources.
Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype typhimurium.
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