Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA6
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AadA6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 22 | STREPTOMYCIN, SPECTINOMYCIN +4 | Pseudomonas aeruginosa +7 | India, Australia, China, Italy, Saudi Arabia, Holtemme river, Saxony-Anhalt, Germany, Singapore, Egypt, clinical|environmental, United States, Western Balkans|Hungary, Europe | 1999, 2006, 2011, 2015, 2019, 2020, 2021, 2023, 2024, 2025 | EF184217.1 | ABO47759.1 |
| ANT(3'') | Card Database | 1 | - | Pseudomonas aeruginosa | - | - | AM087411.1 | CAJ32504.1 |
| aadA6 | ResFinder Database | 1 | STREPTOMYCIN, SPECTINOMYCIN | Pseudomonas aeruginosa | - | 1999 | AF140629 | - |
| aadA6-orfD | Reslit | 1 | streptomycin, spectinomycin | Pseudomonas aeruginosa +1 | Southwest Nigeria | 2013 | JX195555|JX195556 | - |
| aadA6/aadA10 | Reslit | 1 | aminoglycosides | Klebsiella pneumoniae | Shanxi Province, China | 2020 | NCBI BioProject: PRJNA632023 | - |
| aadA 6 | Reslit | 1 | streptomycin | Escherichia coli | Southeast Nigeria | 2022 | PRJEB43719 | - |
Molecular characterisation of In51, a class 1 integron containing a novel aminoglycoside adenylyltransferase gene cassette, aadA6, in Pseudomonas aeruginosa.
Molecular characterisation of In51, a class 1 integron containing a novel aminoglycoside adenylyltransferase gene cassette, aadA6, in Pseudomonas aeruginosa.
Molecular characterisation of In51, a class 1 integron containing a novel aminoglycoside adenylyltransferase gene cassette, aadA6, in Pseudomonas aeruginosa.
Molecular characterisation of In51, a class 1 integron containing a novel aminoglycoside adenylyltransferase gene cassette, aadA6, in Pseudomonas aeruginosa.
Incidence of class 1 integrons in multiple antibiotic-resistant Gram-negative copiotrophic bacteria from the River Torsa in India
The study identified various gene cassettes within class 1 integrons in multiple antibiotic-resistant Gram-negative bacteria from the River Torsa in India, including dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, aac(6')-Ib, aadA1, aadA6, and a novel ORF with homology to dfrA1.
Molecular epidemiology of acquired-metallo-beta-lactamase-producing bacteria in Poland.
Molecular epidemiology of acquired-metallo-beta-lactamase-producing bacteria in Poland.
Molecular epidemiology of acquired-metallo-beta-lactamase-producing bacteria in Poland.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Analysis of integrons and associated gene cassettes in clinical isolates of multidrug resistant Pseudomonas aeruginosa from Southwest Nigeria.
The study identifies aadA6-orfD and aadA13 gene cassettes within class 1 integrons in multidrug-resistant Pseudomonas aeruginosa isolates from Southwest Nigeria, conferring resistance to streptomycin and spectinomycin.
Large-scale genomic sequencing of extraintestinal pathogenic Escherichia coli strains.
High Prevalence of Metallo-β-Lactamase-Producing Enterobacter cloacae From Three Tertiary Hospitals in China.
The study identified multiple metallo-beta-lactamase genes, including blaNDM-1, blaIMP-26, blaIMP-4, blaIMP-1, blaVIM-4, and blaKPC-2, as major contributors to carbapenem resistance in Enterobacter cloacae isolates from three hospitals in China.
First detection of autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 from a patient with bloodstream infection in Italy, October 2019.
The study reports the first autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 strain in Italy, highlighting the presence of multiple beta-lactamase genes, aminoglycoside modifying enzymes, and multidrug efflux pumps contributing to its extensive drug resistance.
Emergence of NDM-5-Producing Carbapenem-Resistant Klebsiella pneumoniae and SIM-Producing Hypervirulent Klebsiella pneumoniae Isolated from Aseptic Body Fluid in a Large Tertiary Hospital, 2017-2018: Genetic Traits of blaNDM-Like and blaSIM-Like Genes as Determined by NGS.
The study identified NDM-5-producing CRKP and SIM-producing hvKP strains, highlighting the emergence of novel resistance mechanisms and the effectiveness of tigecycline-carbapenem combinations in treating these infections.
Genomic Characterization of Carbapenem-Non-susceptible Pseudomonas aeruginosa Clinical Isolates From Saudi Arabia Revealed a Global Dissemination of GES-5-Producing ST235 and VIM-2-Producing ST233 Sub-Lineages.
The study identified GES-5-producing ST235 and VIM-2-producing ST233 sub-lineages of Pseudomonas aeruginosa in Saudi Arabia, highlighting their global dissemination and the presence of various resistance genes including blaGES-5, blaVIM-2, and others.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
The fate of sulfonamide resistance genes and anthropogenic pollution marker intI1 after discharge of wastewater into a pristine river stream.
The study identifies and characterizes several sulfonamide resistance genes (sul1, sul2), the integrase gene intI1, and various other antibiotic resistance genes (ARGs) such as aadA2, aadA11, blaOXA-2, blaOXA-4, blaOXA-10, blaOXA-33, blaOXA-36, blaOXA-129, blaOXA-392, blaOXA-824, blaBEL-1, blaGES-11, ereA2, cmlA5, dfrA1, and qacL. These genes were found in the class 1 integron gene cassettes in the Holtemme river, highlighting the persistence of ARGs downstream from wastewater treatment plant discharge.
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
Altered microbiota, antimicrobial resistance genes, and functional enzyme profiles in the rumen of yak calves fed with milk replacer.
The study identified 138 antimicrobial resistance genes (ARGs) in the rumen of yak calves, with tetracycline resistance being the most prevalent. The study also found that feeding milk replacer (MR) altered the rumen resistome and microbiota, increasing the abundance of Prevotella and affecting the functional enzyme profiles.
Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic.
The study identified high prevalence of carbapenem resistance in Gram-negative pathogens in Egypt, with bla NDM and bla OXA-48-like being the most prevalent carbapenemase genes. Plasmid-mediated quinolone resistance genes qnrS and qnrB were also detected. Additionally, several aminoglycoside resistance genes and integron-associated gene cassettes were characterized.
Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel.
The study identifies variations in antibiotic resistance and life-history traits among the mPact panel of Pseudomonas aeruginosa strains, highlighting the presence of specific AMR genes and mutations contributing to resistance against various antibiotics.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model.
The study identified 15 AMR genes significantly more frequent in high-risk P. aeruginosa clones, including aminoglycoside, beta-lactam, phenicol, fluoroquinolone, trimethoprim, sulfonamide, and tetracycline resistance genes. These genes are often associated with mobile genetic elements, indicating a mobility-linked resistome in high-risk clones.
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