Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside O-nucleotidyltransferase ANT(4')-Ia
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| ANT(4')-Ia | Card DatabaseReference Gene Catalog | 5 | KANAMYCIN, TOBRAMYCIN | Plasmid pUB110 +3 | - | 1984, 1986, 1999, 2010 | AB121443.1 | BAC98411.1 |
| aadD | ResFinder DatabaseReslit | 19 | TOBRAMYCIN, AMIKACIN +2 | Staphylococcus aureus +11 | Germany|United Kingdom|Ireland|France|Malta|Abu Dhabi|Hong Kong|Australia|Trinidad & Tobago|United States|Italy|Spain|Portugal|Switzerland|Canada|Middle East|USA|Asia|UK, global, New Zealand, China, Portugal|Spain|The Netherlands, The Netherlands, South Africa, Europe, Sudan, Africa|Asia|America|Europe|Oceania|global, Malaysia, Germany | 2000, 2011, 2018, 2020, 2021, 2022, 2023, 2024, 2025 | AF181950, M19465 | - |
| aadD1 | Reslit | 1 | aminoglycosides | Staphylococcus | Germany | 2022 | PRJNA903486 | - |
Directed evolution of thermostable kanamycin-resistance gene: a convenient selection marker for Thermus thermophilus.
Genetic organization of the downstream region of the mecA element in methicillin-resistant Staphylococcus aureus isolates carrying different polymorphisms of this region., The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation.
Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States.
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.
The study characterizes various methicillin-resistant Staphylococcus aureus (MRSA) clones, highlighting their antimicrobial resistance and virulence-associated markers, with a focus on SCC mec types and PVL status.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Isolation of a thermostable enzyme variant by cloning and selection in a thermophile.
Genomic Analysis of Multiresistant Staphylococcus capitis Associated with Neonatal Sepsis.
The study identifies several AMR genes in multidrug-resistant Staphylococcus capitis isolates associated with neonatal sepsis, including blaZ, fusB, aadD, qacA, and aac(6')-aph(2'). These genes confer resistance to amoxicillin, fusidic acid, aminoglycosides, chlorhexidine, and gentamicin, respectively.
Presence and Characterization of a Novel cfr-Carrying Tn558 Transposon Derivative in Staphylococcus delphini Isolated From Retail Food.
The study reports the identification of a novel cfr-carrying Tn558 transposon derivative in Staphylococcus delphini isolated from retail food, highlighting the presence of multiple antimicrobial resistance genes including cfr, fexA, aacA-aphD, aadD, and ble.
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.
The study identifies several antimicrobial resistance genes in old Enterococcus faecalis isolates, including tet(L), cat, erm(B), aac(6')-aph(2''), aadD, drfC, and ble, demonstrating the early emergence of antimicrobial resistance traits in this species.
Staphylococcal cassette chromosome mec containing a novel mec gene complex, B4.
The study identifies a novel SCC mec subtype, IVUMCG335, containing a new mec complex organization (IS 431 -Δ mecR1 - mecA -IS 431 -pUB110-IS 431 -ψIS 1272 ) named B4. It also reports the integration of plasmid pUB110 into SCC mec IVc, leading to resistance to bleomycin and aminoglycosides via the genes bleO and aadD.
Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.
The study identified several antibiotic resistance genes (ARGs) in chicken manure, mushroom residues, and heat-treated chicken manure, highlighting the impact of different organic manures on the soil resistome. Key findings include the enrichment of specific ARGs such as aadE, aadD, qacE1, qacH, lnuA, vatE, and tetL in soils treated with various manures, indicating the potential for ARG transfer through manure application.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples.
The study identified several antimicrobial resistance genes in non-aureus staphylococci (NAS) and Staphylococcus aureus, including lnuA, blaZ, ermA, ermB, ermC, mphC, msrA, aadD, aac-aph, str, and norA. These genes conferred resistance to lincomycin, penicillin, macrolides, aminoglycosides, and multiple antibiotics.
Genomic diversity of genus Limosilactobacillus.
The study identified 18 AMR genes in Limosilactobacillus species, primarily in L. reuteri from animal sources, including tetracycline, aminoglycoside, macrolide-lincosamide-streptogramin, and lincomycin resistance genes.
Whole-Genome Sequence of Multidrug-Resistant Methicillin-Resistant Staphylococcus epidermidis Carrying Biofilm-Associated Genes and a Unique Composite of SCCmec.
The study identified multiple antimicrobial resistance genes in multidrug-resistant methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, fusB, fosB, aadD, aac(6')-aph(2"), tet(K), dfrG, msr(A), and qacA. These genes contribute to resistance against various antibiotics such as methicillin, penicillin, fusidic acid, fosfomycin, aminoglycosides, tetracycline, trimethoprim, macrolides, and chlorhexidine.
Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance.
The study identifies various AMR genes such as mecA, blaZ, tet(M), erm(B), aac(6')-aph(2"), aadD, ant(6)-Ia, and sat4 in Staphylococcus aureus and S. pseudintermedius isolates from healthy dogs and cats, indicating widespread antibiotic resistance.
Comparative Genomic Analysis of a Multidrug-Resistant Staphylococcus hominis ShoR14 Clinical Isolate from Terengganu, Malaysia, Led to the Discovery of Novel Mobile Genetic Elements.
The study identified multiple AMR genes in the multidrug-resistant S. hominis ShoR14 isolate, including tetK, norA, aac(6')-aph(2"), aadD, blaZ, mecA, mupA, fusC, ermC, sul4, dfrC, and catA7, which contribute to resistance against various antibiotics.
Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries.
The study found that organic and alternative pig farming practices are associated with reduced antimicrobial resistance (AMR) in non-aureus staphylococci (NAS) compared to conventional farming. Specific AMR genes such as mecA, blaZ, blaPC1, and others were more prevalent in conventional farms, while organic farms showed lower levels of AMR genes for aminoglycosides, phenicols, and tetracyclines.
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Biofilm enhanced the mitigations of antibiotics and resistome in sulfadiazine and trimethoprim co-contaminated soils.
The study identifies several AMR genes, including aadA7, aac(6')-II, aac(3)-iid, aadD, tetA, tetM, tetX, and sul2, in Arthrobacter sp. D2, which are involved in resistance to aminoglycosides, tetracyclines, and sulfonamides. These genes were experimentally validated using high-throughput qPCR analysis.
The characteristics of methicillin-resistant Staphylococcus aureus co-infection in COVID-19 pneumonia.
The study identified several antimicrobial resistance genes in MRSA isolates from patients with COVID-19 pneumonia and MRSA pneumonia without COVID-19, including aac(6')-aph(2''), aph(2'')-Ia, aph(3')-III, aadD, ermA, ermB, ermC, tetM, tetK, mupA, and tst. No significant differences in antimicrobial resistance genes were observed between the two groups.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110.
Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110.
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