Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
6′ adenyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AadE | Reference Gene CatalogResFinder DatabaseReslit | 39 | streptomycin, STREPTOMYCIN +1 | Enterococcus faecium +31 | Taiwan, Italy, Europe, Italy|Spain, China, Poland, Denmark, Japan, New Hampshire, USA, Spain, United States, South Korea, Northeastern Ohio, the United States|Northeastern Ohio, USA|Belgium|Canada, Europe|Netherlands, Germany, Chiang Mai province, Northern Thailand|Thailand, Czech Republic, Belgium, Vietnam, Germany|Vietnam, South Africa, Brazil, Various zoo locations | 2001, 2007, 2008, 2010, 2012, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF330699 | ABB59530.1 |
| aad E | Reslit | 1 | streptomycin | Campylobacter coli | Ghana | 2020 | - | - |
| aadE* | Reslit | 1 | streptomycin | Mycoplasma bovirhinis HAZ141_2 +1 | Japan | 2021 | AP018135.1 | - |
| aad(E) | Reslit | 1 | streptomycin | Enterococcus thailandicus 52 | West Africa | 2023 | - | - |
Aminoglycoside-streptothricin resistance gene cluster aadE-sat4-aphA-3 disseminated among multiresistant isolates of Enterococcus faecium.
The study identifies the aadE-sat4-aphA-3 gene cluster responsible for aminoglycoside and streptothricin resistance in multidrug-resistant Enterococcus faecium isolates.
pEOC01: a plasmid from Pediococcus acidilactici which encodes an identical streptomycin resistance (aadE) gene to that found in Campylobacter jejuni.
pEOC01: a plasmid from Pediococcus acidilactici which encodes an identical streptomycin resistance (aadE) gene to that found in Campylobacter jejuni.
Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
The study identified a multidrug-resistant PVL+ CA-MRSA ST59 strain in Taiwan with a novel SCC mec type VII, carrying resistance genes such as tetK, cat, aadE, aph(3')-IIIa, ermB, blaZ, and cadDX.
The genome of Streptococcus mitis B6--what is a commensal?
The study identifies multiple antibiotic resistance genes in Streptococcus mitis B6, including tetM, aacA-aphD, aphA, sat, and aadE, which confer resistance to tetracycline and aminoglycosides. Additionally, a mutation in rpoB (H486N) was found to confer rifampicin resistance.
Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens.
The study identifies a novel mobile genetic element, 15K, carrying multiple antibiotic resistance genes including tet(O/W/32/O), erm(B), aadE, aphA, and tet(40), which can be transferred between major streptococcal pathogens.
Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis.
The study identifies several AMR genes, including aac(6')-aph(2")-Ia, vanA, vanB, tetM, ermB, aph(3')-IIIa, and sat4, which are associated with resistance to aminoglycosides, glycopeptides, tetracyclines, macrolides, lincosamides, streptogramin B, and streptothricin in Enterococcus faecium and Enterococcus faecalis.
Antibiotic Susceptibility Profiles of Dairy Leuconostoc, Analysis of the Genetic Basis of Atypical Resistances and Transfer of Genes In Vitro and in a Food Matrix.
The study identified several AMR genes in Leuconostoc strains, including erm(B) for erythromycin resistance, tet(S) for tetracycline resistance, and others like aadE, aphA-3, sat4, and vat(E) for aminoglycoside and virginiamycin resistance.
Virulence and Genomic Feature of Multidrug Resistant Campylobacter jejuni Isolated from Broiler Chicken.
The study identified multiple AMR genes and mutations in Campylobacter jejuni 1655, including gyrA T86I mutation, 23S rRNA A2075G mutation, tetO, aphA, and aadE genes, contributing to resistance against fluoroquinolones, macrolides, tetracycline, and aminoglycosides.
Assessment of antibiotic susceptibility in Lactobacillus isolates from chickens.
The study identified several tetracycline, macrolide, and aminoglycoside resistance genes in Lactobacillus isolates from chickens, highlighting the presence of resistance mechanisms in these bacteria.
ICESag37, a Novel Integrative and Conjugative Element Carrying Antimicrobial Resistance Genes and Potential Virulence Factors in Streptococcus agalactiae.
The study characterizes ICE Sag37, a novel integrative and conjugative element carrying multiple antimicrobial resistance genes, including erm(B), tet(O), aadE, aphA, and ant(6), in Streptococcus agalactiae.
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.
The study identified several tetracycline, macrolide, and lincosamide resistance genes in turkey-derived lactobacilli, including tetL, tetM, tetW, ermB, ermC, lnuA, aadE, ant(6)-Ia, cat, and lsaE. These genes were associated with resistance to tetracycline, erythromycin, lincomycin, streptomycin, chloramphenicol, and tiamulin.
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
The study identified multiple antimicrobial resistance genes, including aac(6')-Ib, ermB, tetM, and catD, in Clostridium difficile isolates from clade 4, highlighting the role of mobile genetic elements in the evolution of multidrug resistance.
Complete hybrid genome assembly of clinical multidrug-resistant Bacteroides fragilis isolates enables comprehensive identification of antimicrobial-resistance genes and plasmids.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Bacteroides fragilis isolates, including cfiA, nim, erm, tet, and others, using hybrid genome assembly and ABRicate screening.
Novel Multidrug-Resistant Enterococcal Mobile Linear Plasmid pELF1 Encoding vanA and vanM Gene Clusters From a Japanese Vancomycin-Resistant Enterococci Isolate.
The study identifies a novel multidrug-resistant enterococcal mobile linear plasmid pELF1 that encodes vanA and vanM gene clusters, conferring resistance to vancomycin, as well as other antibiotics such as streptomycin, streptothricin, kanamycin, and erythromycin.
Genomic Epidemiology and Evolution of Diverse Lineages of Clinical Campylobacter jejuni Cocirculating in New Hampshire, USA, 2017.
The study identified multiple horizontally acquired resistance genes in Campylobacter jejuni isolates from New Hampshire, including genes conferring resistance to beta-lactams, aminoglycosides, streptothricin, and tetracycline.
Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter.
The study characterizes two S. aureus ST398 strains, one methicillin-resistant (MRSA) and one methicillin-susceptible (MSSA), isolated from a pig transporter. The MRSA strain harbors the mecA gene, while the MSSA strain lacks it due to a large deletion. Both strains exhibit resistance to several antibiotics including tetracycline, lincosamides, aminoglycosides, and trimethoprim.
Comparison of Molecular Subtyping and Antimicrobial Resistance Detection Methods Used in a Large Multistate Outbreak of Extensively Drug-Resistant Campylobacter jejuni Infections Linked to Pet Store Puppies.
The study identified multiple antimicrobial resistance genes and mutations in Campylobacter jejuni isolates from a large multistate outbreak linked to pet store puppies, including resistance to tetracycline, aminoglycosides, macrolides, fluoroquinolones, and others.
Characterization of Campylobacter associated gastric enteritis among patients with Human Immunodeficiency Virus (HIV) in a hospital in Accra, Ghana.
The study identified Campylobacter coli isolates resistant to multiple antibiotics, including tetracycline, ciprofloxacin, and erythromycin, with the presence of resistance genes bla OXA-61, cme B, tet (O), and aad E.
A Possible Role of Insertion Sequence IS1216V in Dissemination of Multidrug-Resistant Elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus.
The study identifies the role of insertion sequence IS1216V in the dissemination of multidrug-resistant elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus, highlighting the contribution of IS1216V in mediating the transfer of resistance genes such as ermB, aph(3')-IIIa, aadE, aacA-aphD, and cat.
Molecular Characteristics of IS1216 Carrying Multidrug Resistance Gene Cluster in Serotype III/Sequence Type 19 Group B Streptococcus.
The study identified multidrug resistance gene clusters in non-srr1/2 serotype III Group B Streptococcus (GBS) isolates, including lnu(B), lsa(E), aadK, aadE, and aac(3)-IV, which confer resistance to lincosamides, streptomycin, and aminoglycosides.
The aadE*-sat4-aphA-3 Gene Cluster of Mycoplasma bovirhinis HAZ141_2 Undergoes Genomic Rearrangements Influencing the Primary Promoter Sequence.
The aadE*-sat4-aphA-3 gene cluster in Mycoplasma bovirhinis HAZ141_2 undergoes genomic rearrangements, including inversions and deletions, which affect the primary promoter sequence and influence gene expression. The genes aadE*, sat4, and aphA-3 confer resistance to streptomycin, streptothricin/nourseothricin, and kanamycin/neomycin, respectively.
Prevalence and Antimicrobial Resistance Profiles of Foodborne Pathogens Isolated from Dairy Cattle and Poultry Manure Amended Farms in Northeastern Ohio, the United States.
The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.
Assessing the drug resistance profiles of oral probiotic lozenges.
The study identified several antibiotic resistance genes in probiotic lozenges, including erm(T), rpoB, gyr(A), parC, dfrD, aph(3”)-III, ant(2”)-I, erm(B), mefA, cat-TC, vanX, and vatE, which confer resistance to erythromycin, rifampicin, fluoroquinolones, trimethoprim, kanamycin, gentamicin, chloramphenicol, vancomycin, and quinupristin/dalfopristin.
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
Early-life broad-spectrum antibiotics alter the infant gut microbiome and resistome, with amoxicillin + cefotaxime having the most significant impact on AMR gene profiles.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
Characterization of Campylobacter jejuni in large-billed crows (Corvus macrorhynchos) in Tochigi prefecture, Japan.
The study identified tetracycline resistance mediated by the tetO gene and streptomycin resistance mediated by the aadE gene in Campylobacter jejuni isolates from large-billed crows in Japan.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
The study identified 18 AMR genes in non-serotype 2 Streptococcus suis isolates from healthy pigs, including genes conferring resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, oxazolidinones, nucleosides, and phenicols.
Association of CRISPR-Cas System with the Antibiotic Resistance and Virulence Genes in Nosocomial Isolates of Enterococcus.
The study found that the CRISPR-Cas system is associated with reduced antibiotic resistance and virulence in Enterococcus isolates. Specific resistance genes such as ermB, aadE, ant(6), aac(6')-aph(2"), tetM, and vanA were identified in the isolates.
Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics.
The study identifies the presence of the integrative and conjugative element ICE Sag37 in type Ib ST12 GBS isolates, which carries multiple antibiotic resistance genes such as erm(B), tet(O), aadE, aphA, ant-6, lsa(E), and lun(B), contributing to high resistance rates to erythromycin and clindamycin. Additionally, the virulence gene pezT was found in these isolates.
Antibiotic Susceptibility, Resistance Gene Determinants and Corresponding Genomic Regions in Lactobacillus amylovorus Isolates Derived from Wild Boars and Domestic Pigs.
The study identified tetracycline resistance gene tetW, erythromycin resistance gene ermB, and streptomycin resistance gene aadE in Lactobacillus amylovorus isolates from domestic pigs, while only one wild boar isolate carried aadE. The findings highlight differences in resistance gene prevalence between wild and domestic pigs.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
Genomic insight into Campylobacter jejuni isolated from commercial turkey flocks in Germany using whole-genome sequencing analysis.
The study identified multiple beta-lactam resistance genes (blaOXA variants), tetracycline resistance gene tet(O), aminoglycoside resistance genes (aadE, aph(3')-IIIa, sat4), and a fluoroquinolone resistance mutation (gyrA T86I) in Campylobacter jejuni isolates from German turkey flocks.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Antimicrobial Resistance of Lactic Acid Bacteria from Nono, a Naturally Fermented Milk Product.
The study identified tetracycline resistance genes tet(S) and tet(M) in Enterococcus thailandicus 52 and Streptococcus infantarius 10, as well as the streptomycin resistance gene aad(E) in Enterococcus thailandicus 52. These genes were shown to be transferable to Enterococcus faecalis JH2-2.
Genomic and Antimicrobial Surveillance of Campylobacter Population in Italian Poultry.
The study identified several AMR genes and mutations in Campylobacter isolates from Italian poultry, highlighting the emergence of multidrug-resistant strains and the prevalence of specific resistance mechanisms such as the T86I mutation in gyrA and the tet(O) gene.
Prevalence, antibiotic resistance, and genomic characterisation of Campylobacter spp. in retail chicken in Hanoi, Vietnam.
The study identified multiple AMR genes and mutations in Campylobacter isolates from retail chicken in Hanoi, Vietnam, including aminoglycoside resistance genes (aadE, aadA9, aph(2'')-If, aac(6')-Ie/aph(2'')-Ia), erythromycin resistance gene ermB, tetracycline resistance gene tet(O), beta-lactam resistance gene blaOXA-193, and a quinolone resistance mutation (T86I) in gyrA.
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
The study identified 22 different resistance genes and gene variants, including erm(B), aph(3')-IIIa, aadE, catA, lnu(C), blaOXA, sat4, tet(O), and point mutations in gyrA, 23S rRNA, and rpsL, associated with antimicrobial resistance in thermotolerant Campylobacter spp.
Detection of Salmonella Pathogenicity Islands and Antimicrobial-Resistant Genes in Salmonella enterica Serovars Enteritidis and Typhimurium Isolated from Broiler Chickens.
The study identified several antimicrobial-resistant genes in Salmonella enterica serovars Enteritidis and Typhimurium isolated from broiler chickens, including tet(K), tet(O), tet(A), mcr-1, mcr-4, strA, strB, aadA, aadE, sulI, ampC, TEM, CTX-M, and OXA. These genes conferred resistance to tetracycline, colistin, aminoglycosides, sulfonamides, and beta-lactam antibiotics.
Five centuries of genome evolution and multi-host adaptation of Campylobacter jejuni in Brazil.
The study identifies beta-lactam resistance genes blaOXA-193 and blaOXA-184, as well as the multidrug efflux pump operon cmeABCR in Campylobacter jejuni isolates from Brazil. Mutations in gyrA and rrn genes are associated with quinolone and macrolide resistance.
Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes.
The study identified various AMR genes in zoo animal microbiomes, including resistance to tetracyclines, lincomamides, fluoroquinolones, vancomycin, beta-lactams, and aminoglycosides.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
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