Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump
Overview
Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii.
The paper discusses the antibiotic resistance profiles and molecular mechanisms of Acinetobacter baumannii, highlighting the presence of various beta-lactamases such as blaOXA-23, blaOXA-51, blaOXA-24/40, blaOXA-58, blaOXA-143, blaOXA-235, blaIMP, blaVIM, and blaNDM, as well as aminoglycoside-modifying enzymes like aac(6')-Ib, aph(3')-Ia, and ant(2'')-Ia. It also identifies efflux pumps such as adeABC and tetracycline resistance genes like tet(A).
Unearthing Antibiotic Resistance Associated with Disturbance-Induced Permafrost Thaw in Interior Alaska.
The study identified various antibiotic resistance genes in Alaskan soil bacteria, highlighting the influence of phylogeny and disturbance on the resistome. Key genes included adeF, AbaQ, FosB, BcII, bcrC, TriC, KpnF, and BES-1, which conferred resistance to multidrug, quinolones, penicillins, cephalosporins, peptide antibiotics, triclosan, and broad-spectrum antibiotics.
Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors.
The study identifies the overexpression of efflux pump genes such as adeJ, adeG, adeB, abeM, abaQ, and craA in Acinetobacter baumannii strains, contributing to fluoroquinolone resistance. It also evaluates new 1-(1-naphthylmethyl)-piperazine analogs as potential efflux pump inhibitors.
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt.
The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.
In Vitro Activity of Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates: A Multicentre Report from Italy.
The study evaluated the in vitro activity of sulbactam-durlobactam (SUL-DUR) against 141 carbapenem-resistant A. baumannii isolates. It identified several resistance genes including blaOXA-20, blaOXA-58, blaOXA-66, blaADC-25, aac(6')-Ib3, aac(6')-Ib-cr, and mutations in gyrA (S81L) and parC (V104I, D105E). Additionally, mutations in PBP3 (Q488K and Y528H) were found in SUL-DUR resistant isolates.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Whole-Genome Sequencing of Pseudomonas koreensis Isolated from Diseased Tor tambroides.
The study identified five antibiotic resistance genes in Pseudomonas koreensis CM-01, including soxR, adeF, AbaQ, and FosA, which contribute to resistance against ampicillin, aztreonam, clindamycin, and cefoxitin.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
Environmental contamination with carbapenem resistant Acinetobacter baumannii in healthcare settings in Fiji: a potential source of infection.
The study identified several carbapenem-resistant Acinetobacter baumannii (CR Ab) isolates from high-touch surfaces in Fijian hospitals, revealing the presence of resistance genes such as bla OXA-23, bla NDM-1, and others, along with mutations in genes like parC and gyrA, contributing to resistance against multiple antibiotics.
Investigating the resistome of haemolytic bacteria in Arctic soils.
The study identified multiple AMR genes in Arctic haemolytic bacteria, including genes encoding efflux pumps and ribosomal protection proteins, indicating the presence of resistance mechanisms against various antibiotics.
Genomic Characterization and Antibiotic Resistance Profiles of Acinetobacter baumannii Isolates From Intensive Care Units in Vietnam.
The study identifies multiple AMR genes in three CRAB isolates, including blaOXA-23, blaOXA-66, blaADC-198, blaADC-73, and various aminoglycoside modifying enzymes, efflux pumps, and sulfonamide resistance genes, highlighting the extensive multidrug resistance in these isolates.
Genomic and phenotypic characterization of six multidrug-resistant Acinetobacter pittii isolates.
The study identified multiple beta-lactamase genes, including blaOXA-72, blaOXA-272, and blaOXA-255, which confer resistance to carbapenems. Additionally, other resistance genes such as blaADC-245, blaADC-150, and others were found to confer resistance to cephalosporins. Efflux pump genes like adeF, abaQ, and abeS were associated with resistance to fluoroquinolones and tetracyclines. The gene lpsB was linked to colistin resistance.
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