accA

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acetyl-coenzyme A carboxylase

NCBI Pathogen Isolates

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UniProt

Protein entries specific to accA

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Validation StatusCandidate

Overview

Mechanism: mutation in the accA gene leads to triclosan resistance
Validation Method: genomic sequencing and complementation experiments
Drug Classes: triclosan
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

Triclosan-resistant small-colony variants of Staphylococcus aureus produce less capsule, less phenol-soluble modulins, and are attenuated in a Galleria mellonella model of infection.

PMID 36748621 · 2023

The study identifies a mutation in the accA gene that confers triclosan resistance in a small-colony variant (SCV) of Staphylococcus aureus, which also exhibits reduced capsule production and virulence in an insect model.

Gene Information

Gene Name: accA
Allele: accA
Encodes: acetyl-coenzyme A carboxylase
Source Database: Reslit
Mechanism: mutation in the accA gene leads to triclosan resistance
Confers Resistance To: triclosan
Organisms Tested In: • Staphylococcus aureus
Validation Method: genomic sequencing and complementation experiments
Sequence Accession: PRJNA872918

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accA

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accA

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