acrZ

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small protein interacting with AcrB

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to acrZ

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Validation StatusCandidate

Overview

Validation Method: knockout experiments showing loss of chloramphenicol resistance
Drug Classes: phenicols
Organisms: Escherichia coli K12
Papers: 1
Databases: Reslit

Papers1

Combined exposure to non-antibiotic pharmaceutics and antibiotics in the gut synergistically promote the development of multi-drug-resistance in Escherichia coli.

PMID 35014598 · 2022

Combined exposure to duloxetine and chloramphenicol synergistically enhances multidrug resistance in E. coli through upregulation of efflux pumps AcrAB-TolC and MlaFEDB, and mutations in marR.

Gene Information

Gene Name: acrZ
Allele: acrZ
Encodes: small protein interacting with AcrB
Source Database: Reslit
Confers Resistance To: phenicols
Organisms Tested In: • Escherichia coli K12
Validation Method: knockout experiments showing loss of chloramphenicol resistance

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acrZ

Gene Information

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acrZ

Gene Information