Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
multidrug efflux pump
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| acrEF | Reslit | 9 | fluoroquinolones, tetracycline +20 | Escherichia coli +4 | South America | 2001, 2004, 2005, 2011, 2015, 2023 | ASM694v2 | - |
| AcrEF | Reslit | 1 | fluoroquinolones, chloramphenicol florfenicol +1 | Salmonella enterica serovar Typhimurium | - | 2022 | - | - |
Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.
The study identifies the enhanced expression of multidrug efflux pumps AcrAB and AcrEF in Escherichia coli mutants selected with a fluoroquinolone, associated with insertion element transposition. The mutations in acrR and acrS lead to increased resistance to various antibiotics.
Analysis of a complete library of putative drug transporter genes in Escherichia coli.
The study identified 20 genes in Escherichia coli that confer resistance to various antimicrobial agents, including novel drug resistance determinants such as yceE, yceL, yidY, ydgFE, yegO, cusA, and ybjYZ. Additionally, several previously known genes were found to have broader resistance spectra than previously reported.
Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).
The study identified several efflux transporter genes, including tet(B), tet(C), tet(K), acrAB, acrEF, and bcr, that influence the susceptibility of Escherichia coli to tigecycline. While tigecycline was effective against strains expressing these efflux pumps, it was found to be a substrate for AcrAB and AcrEF, suggesting potential resistance mechanisms.
Overexpression of the multidrug efflux operon acrEF by insertional activation with IS1 or IS10 elements in Salmonella enterica serovar typhimurium DT204 acrB mutants selected with fluoroquinolones.
Insertional activation of the acrEF operon via IS1 or IS10 elements leads to overexpression of the AcrEF efflux pump, restoring high-level fluoroquinolone resistance in Salmonella enterica serovar Typhimurium DT204 acrB mutants.
Exposure of Salmonella enterica serovar Typhimurium to high level biocide challenge can select multidrug resistant mutants in a single step.
The study identified the AcrEF multidrug efflux pump as a key mediator of multidrug resistance in Salmonella enterica serovar Typhimurium following exposure to biocides.
Importance of Real-Time Assays To Distinguish Multidrug Efflux Pump-Inhibiting and Outer Membrane-Destabilizing Activities in Escherichia coli.
The study identifies that PAβN primarily functions as an inhibitor of the AcrAB and AcrEF multidrug efflux pumps in Escherichia coli, distinguishing its effect from outer membrane destabilization.
Mathematical Modelling Highlights the Potential for Genetic Manipulation as an Adjuvant to Counter Efflux-Mediated MDR in Salmonella.
The study highlights the role of RND efflux pump systems in mediating multidrug resistance (MDR) in Salmonella, particularly focusing on AcrAB, AcrEF, MdsAB, and MdtAB. Experimental data shows that overexpression of these efflux pumps leads to resistance against fluoroquinolones, chloramphenicol-florfenicol, and tetracyclines.
Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Salmonella Typhimurium Isolated from Human Milk.
The study identified several antimicrobial resistance genes in Salmonella Typhimurium 69M, including aac(6')-Ib-cr, acrAB, acrEF, mdtABC, and macA, which are associated with resistance to various antibiotics. Additionally, mutations in rfbP were found to affect the O-antigen synthesis and may influence bacterial virulence.
Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosa.
The study characterizes the role of RND multidrug efflux pumps in drug resistance and physiological functions in Salmonella enterica, Escherichia coli, and Pseudomonas aeruginosa. Key findings include the identification of multiple RND efflux pumps and their contributions to multidrug resistance, biofilm formation, and cellular processes.
CTX-M-producing Escherichia coli ST602 carrying a wide resistome in South American wild birds: Another pandemic clone of One Health concern.
The study identifies two CTX-M-producing E. coli ST602 strains, UNB7 and GP188, from wild birds in Brazil and Chile, carrying a wide resistome against antibiotics, heavy metals, disinfectants, and herbicides.
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