Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
resistance-nodulation-cell division (RND) antibiotic efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G288S | - | increased meropenem MIC to ≥8 µg ml−1 | Acinetobacter baumannii | meropenem | Reslit | Candidate |
| Y327A | - | increased resistance | E. coli | ethidium bromide|phenicols|levofloxacin | Reslit | Candidate |
| T605F | - | increased resistance | E. coli | phenicols|levofloxacin | Reslit | Candidate |
| Q292K | - | increased resistance | E. coli | ethidium bromide|phenicols|levofloxacin | Reslit | Candidate |
| W610F | - | increased resistance | E. coli | phenicols|levofloxacin | Reslit | Candidate |
| G306V | - | - | Acinetobacter baumannii | aminoglycosides|cephalosporins|fluoroquinolones|tigecycline | Reslit | Candidate |
| N427S | - | - | Acinetobacter baumannii | aminoglycosides|cephalosporins|fluoroquinolones|tigecycline | Reslit | Candidate |
| A562T | - | - | Acinetobacter baumannii | aminoglycosides|cephalosporins|fluoroquinolones|tigecycline | Reslit | Candidate |
| A643D | - | - | Acinetobacter baumannii | aminoglycosides|cephalosporins|fluoroquinolones|tigecycline | Reslit | Candidate |
| T646S | - | - | Acinetobacter baumannii | aminoglycosides|cephalosporins|fluoroquinolones|tigecycline | Reslit | Candidate |
| S437T | - | - | Acinetobacter baumannii | tetracycline | Reslit | Candidate |
| T48V | - | deleterious | Acinetobacter baumannii | carbapenems | Reslit | Candidate |
| T584I | - | deleterious | Acinetobacter baumannii | carbapenems | Reslit | Candidate |
| P660Q | - | deleterious | Acinetobacter baumannii | carbapenems | Reslit | Candidate |
| - | - | Klebsiella pneumoniae | phenicols|tetracycline|fluoroquinolones | Reslit | Candidate |
Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454.
The study identifies the adeB gene, which encodes a resistance-nodulation-cell division (RND) protein, as responsible for aminoglycoside resistance in Acinetobacter baumannii strain BM4454. The AdeB protein contributes to resistance against multiple antibiotics, including aminoglycosides, tetracyclines, fluoroquinolones, macrolides-lincosamides-streptogramins, and beta-lactams.
Distribution of tetracycline resistance genes in genotypically related and unrelated multiresistant Acinetobacter baumannii strains from different European hospitals.
The study identified tet(A), tet(B), and tet(M) as tetracycline resistance genes in Acinetobacter baumannii strains, with tet(B) additionally conferring resistance to minocycline. The efflux gene adeB was present in all strains regardless of tet gene status.
Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii.
The study identifies the AdeABC efflux pump as a mechanism for tigecycline nonsusceptibility in Acinetobacter baumannii, demonstrating that increased expression of adeB contributes to reduced susceptibility.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii: Major Role for AdeABC Overexpression and AdeRS Mutations.
The study identifies mutations in the AdeRS two-component system that lead to overexpression of the AdeABC efflux pump, contributing to multidrug resistance in Acinetobacter baumannii.
Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii.
The study identifies multiple efflux pumps, porins, and β-lactamases contributing to multidrug resistance in Acinetobacter baumannii, including adeB, adeJ, tetB, tetA(39), and aacC1, aphA1, aadB genes, along with mutations in gyrA and parC.
Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility.
The BaeSR two-component system regulates the expression of the AdeAB efflux pump genes in Acinetobacter baumannii, thereby influencing tigecycline susceptibility.
Detection of AdeABC efflux pump genes in tetracycline-resistant Acinetobacter baumannii isolates from burn and ventilator-associated pneumonia patients.
The study found that all tetracycline-resistant Acinetobacter baumannii isolates possessed the AdeABC efflux pump genes, and the efflux pump contributed to tetracycline resistance as evidenced by reduced MICs upon CCCP treatment.
Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance.
The study identified that the upregulation of adeB, adeJ, and macB genes is responsible for tigecycline resistance, while increased abeS expression is strongly related to amikacin resistance in multidrug-resistant Acinetobacter baumannii isolates.
The Role of the Two-Component System BaeSR in Disposing Chemicals through Regulating Transporter Systems in Acinetobacter baumannii.
The study identifies that the BaeSR two-component system regulates the expression of efflux pump genes adeA, adeB, adeI, adeJ, adeK, macA, macB, and tolC in Acinetobacter baumannii, contributing to tigecycline resistance. Deletion of baeR reduces the expression of these genes, leading to increased susceptibility to tannic acid and tigecycline.
Microbicides Alter the Expression and Function of RND-Type Efflux Pump AdeABC in Biofilm-Associated Cells of Acinetobacter baumannii Clinical Isolates.
The study shows that microbicides like cetrimide (CT) and chlorhexidine (CHX) affect the expression and function of the RND-type efflux pump AdeABC in Acinetobacter baumannii, leading to reduced biofilm viability and increased susceptibility to antimicrobials.
Acinetobacter baumannii quorum-sensing signalling molecule induces the expression of drug-resistance genes.
The study identifies that the quorum-sensing signaling molecule N-3-OH-C12-HSL induces the expression of drug-resistance genes OXA-51, AmpC, AdeA, and AdeB in Acinetobacter baumannii, enhancing resistance to meropenem.
Genomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.
The study identified a β-lactam resistance gene, NPS β-lactamase, and several multidrug resistance efflux pump genes, including acrB, cmeB, macA, and macB, in Pannonibacter phragmitetus strain 31801, which contributes to its resistance to various antibiotics.
Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in Acinetobacter baumannii.
The study shows that overproduction of efflux pumps, particularly the RND family members adeB, adeG, and adeJ, leads to reduced susceptibility to carbapenems in Acinetobacter baumannii under consecutive imipenem-selected stress. A single nucleotide mutation in the adeR gene of the adeRS regulatory system was identified as a potential cause of this overproduction.
Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978.
The study identifies that the AdeAB efflux pump, regulated by the AdeRS two-component system, mediates resistance to pentamidine, chlorhexidine, and DAPI in Acinetobacter baumannii ATCC 17978. Deletion of adeRS or adeAB reduces resistance to these dicationic compounds, while complementation restores resistance.
Characterization of an Environmental Multidrug-Resistant Acinetobacter seifertii and Comparative Genomic Analysis Reveals Co-occurrence of Antimicrobial Resistance and Metal Tolerance Determinants.
The study characterizes an environmental multidrug-resistant Acinetobacter seifertii isolate (SAb133) and identifies multiple antimicrobial resistance genes, metal tolerance genes, and virulence factors. Key findings include the presence of bla ADC–25, bla TEM, and various efflux pump genes, along with metal tolerance genes and virulence factors.
Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance.
The study identifies several efflux pumps in Acinetobacter baumannii, including AdeABC, AbeM, AbaF, and AbeS, which contribute to multidrug resistance. These pumps are involved in the efflux of various antibiotics and other antimicrobial agents.
Acinetobacter baumannii Resistance: A Real Challenge for Clinicians.
The paper discusses the various resistance mechanisms in Acinetobacter baumannii, highlighting the presence of genes such as blaOXA-23, blaOXA-51, ArmA, and adeB, which confer resistance to carbapenems, aminoglycosides, and other antibiotics. It also notes the importance of understanding these mechanisms for effective treatment strategies.
Synergistic Antibacterial Activity of Combined Antimicrobials and the Clinical Outcome of Patients With Carbapenemase-Producing Acinetobacter baumannii Infection.
The study identified bla OXA--23 as the primary carbapenemase gene in CRAB strains, and overexpression of efflux pump genes adeB, adeJ, and abeM contributed to resistance. Polymyxin plus sulbactam showed the highest synergistic effect against CRAB.
AdeABC Efflux Pump Controlled by AdeRS Two Component System Conferring Resistance to Tigecycline, Omadacycline and Eravacycline in Clinical Carbapenem Resistant Acinetobacter nosocomialis.
The study shows that the AdeABC efflux pump, regulated by the AdeRS two-component system, contributes to resistance against tigecycline, omadacycline, and eravacycline in clinical carbapenem-resistant Acinetobacter nosocomialis isolates.
Rescued chlorhexidine activity by resveratrol against carbapenem-resistant Acinetobacter baumannii via down-regulation of AdeB efflux pump.
Resveratrol enhances chlorhexidine susceptibility by down-regulating the AdeB efflux pump in carbapenem-resistant Acinetobacter baumannii.
Overexpression of Efflux Pumps, Mutations in the Pumps' Regulators, Chromosomal Mutations, and AAC(6′)-Ib-cr Are Associated With Fluoroquinolone Resistance in Diverse Sequence Types of Neonatal Septicaemic Acinetobacter baumannii: A 7-Year Single Center Study.
The study identifies aac(6')-Ib-cr as a significant contributor to fluoroquinolone resistance in Acinetobacter baumannii, alongside chromosomal mutations in gyrA and parC, and overexpression of efflux pumps regulated by adeR and adeS.
Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors.
The study identifies the overexpression of efflux pump genes such as adeJ, adeG, adeB, abeM, abaQ, and craA in Acinetobacter baumannii strains, contributing to fluoroquinolone resistance. It also evaluates new 1-(1-naphthylmethyl)-piperazine analogs as potential efflux pump inhibitors.
Overexpression of the adeB Efflux Pump Gene in Tigecycline-Resistant Acinetobacter baumannii Clinical Isolates and Its Inhibition by (+)Usnic Acid as an Adjuvant.
The study identifies adeB overexpression as a key mechanism of tigecycline resistance in Acinetobacter baumannii and shows that (+)Usnic acid enhances tigecycline efficacy by inhibiting the AdeB efflux pump.
Structural and Functional Analysis of the AdeB Multidrug Efflux Pump in Acinetobacter baumannii
Antibacterial Efficacy of Liposomal Formulations Containing Tobramycin and N-Acetylcysteine against Tobramycin-Resistant Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii.
The study identified various aminoglycoside-modifying enzymes (AMEs) and efflux pump genes contributing to tobramycin resistance in E. coli, K. pneumoniae, and A. baumannii. These genes include acc(3)-IIa, aac(6')-Ib-cr, ant(2")-Ia, aph(6)-Id, aph(3")-Ib, armA, rmtF, acrD, adeA, adeB, adeC, ompA, omp37, csgB, csgD, csgF, csgG, pgaA, pgaB, pgaC, pgaD, csuA, csuB, csuC, csuD, csuE, and bap.
Synergistic Inhibitory Effect of Polymyxin B in Combination with Ceftazidime against Robust Biofilm Formed by Acinetobacter baumannii with Genetic Deficiency in AbaI/AbaR Quorum Sensing.
The study identifies bla OXA-23, IS Aba1, and several efflux pump genes (adeA, adeB, adeC, adeS, adeR) as contributing to carbapenem and multidrug resistance in Acinetobacter baumannii. Additionally, the AbaI/AbaR quorum sensing system is implicated in regulating biofilm formation and motility.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
Efflux-Related Carbapenem Resistance in Acinetobacter baumannii Is Associated with Two-Component Regulatory Efflux Systems' Alteration and Insertion of ΔAbaR25-Type Island Fragment.
Synergistic Role of Biofilm-Associated Genes and Efflux Pump Genes in Tigecycline Resistance of Acinetobacter baumannii.
The study identifies adeB and bfs genes as key contributors to tigecycline resistance in Acinetobacter baumannii, highlighting their roles in efflux pump activity and biofilm formation.
Global genomic epidemiology of chromosomally mediated non-enzymatic carbapenem resistance in Acinetobacter baumannii: on the way to predict and modify resistance.
The study identifies several genes and mutations associated with carbapenem resistance in Acinetobacter baumannii, including efflux pump components (AdeB, AdeC, AdeS), penicillin-binding proteins (PBP1a), and outer membrane porins (OprB, OprD, CarO). Mutations in these genes are linked to altered carbapenem susceptibility.
Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria.
The paper discusses various antibiotic resistance mechanisms in Gram-negative bacteria, highlighting the role of beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps in conferring resistance to multiple antibiotics.
Genomic analysis of multidrug-resistant Delftia tsuruhatensis isolated from raw bovine milk.
The study identifies multiple efflux pump genes and a genus-specific OXA-926-like beta-lactamase in the multidrug-resistant Delftia tsuruhatensis strain MR-6/3H, contributing to resistance against various antibiotics.
Regulation of overexpressed efflux pump encoding genes by cinnamon oil and trimethoprim to abolish carbapenem-resistant Acinetobacter baumannii clinical strains.
The study identifies the efflux pump genes adeB, adeC, adeJ, and adeK as contributing to carbapenem resistance in Acinetobacter baumannii. The use of cinnamon oil and trimethoprim was shown to downregulate these genes, thereby reducing resistance.
The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline.
The study identified the RND efflux pump AdeABC as a key factor in tigecycline resistance in Acinetobacter baumannii under sub-MIC conditions. High expression of adeA and adeB was associated with rapid tigecycline resistance acquisition.
The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates.
The study identified multiple biocide resistance genes in Brazilian ESKAPE isolates, highlighting the presence of resistance mechanisms against benzalkonium chloride, chlorhexidine, and triclosan. Key genes included efflux pumps (acrE/envC, acrF/envD, adeA, adeB, adeC, mexD, oqxA, oqxB, qacA, qacR, sdeB), enzyme modifiers (fabV, sh-fabI), and porins (kpnO).
Genome-wide sRNA and mRNA transcriptomic profiling insights into carbapenem-resistant Acinetobacter baumannii.
The study identified differentially expressed sRNAs and mRNAs in carbapenem-resistant Acinetobacter baumannii, highlighting the involvement of adeK, pgaC, adeB, and katG in resistance mechanisms.
Reciprocal regulation between Acinetobacter baumannii and Enterobacter cloacae AdeR homologs: implications for antimicrobial resistance and pathogenesis.
The study identifies and characterizes the roles of AdeB and AdeR homologs in Acinetobacter baumannii and Enterobacter cloacae, demonstrating their involvement in antimicrobial resistance, motility, and virulence. The AdeR regulators from both species are functionally interchangeable, highlighting conserved regulatory mechanisms.
Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant Acinetobacter baumannii AYE.
The study identifies the contributions of RND efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence in multidrug-resistant Acinetobacter baumannii AYE. Disruption of these pumps reduces resistance to multiple antimicrobial classes and affects biofilm formation and virulence.
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