Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
resistance-nodulation-cell division (RND) antibiotic efflux pump
Overview
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Vibrios from the Norwegian marine environment: Characterization of associated antibiotic resistance and virulence genes.
The study identified various antibiotic resistance genes in Vibrio isolates from the Norwegian marine environment, including beta-lactamases (blaCARB, blaampC, varG), tetracycline resistance genes (tet34, tet35), a multidrug efflux pump (adeF), a quinolone resistance gene (qnr), and a chloramphenicol resistance gene (catB-related).
Genomic Analysis of Aeromonas veronii C198, a Novel Mcr-3.41-Harboring Isolate from a Patient with Septicemia in Thailand.
The study identified a novel mcr-3.41 gene in the Aeromonas veronii isolate C198, which confers resistance to colistin. Additionally, other resistance genes such as bla_cphA3, bla_OXA-12, tetA, adeF, and rsmA were found to contribute to resistance against various antibiotics.
Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?
The paper discusses the mechanisms of biocide tolerance and antibiotic resistance in bacteria, highlighting the role of mutations, horizontal gene transfer, efflux pumps, membrane alterations, and biofilms in developing resistance to disinfectants and antibiotics. It emphasizes the risks posed by the extensive use of disinfectants during the COVID-19 pandemic and the potential for increased antimicrobial resistance.
Hospital sink traps as a potential source of the emerging multidrug-resistant pathogen Cupriavidus pauculus: characterization and draft genome sequence of strain MF1.
The study identifies 12 antibiotic resistance genes in the draft genome of Cupriavidus pauculus strain MF1, including genes encoding β-lactamases, efflux pumps, and a colistin resistance determinant. The isolate shows resistance to meropenem, amoxicillin, amikacin, gentamicin, and colistin, but susceptibility to cefotaxime, cefepime, imipenem, and ciprofloxacin.
Antimicrobial Resistance and Comparative Genomic Analysis of Elizabethkingia anophelis subsp. endophytica Isolated from Raw Milk.
The study reports the first isolation of Elizabethkingia anophelis subsp. endophytica from raw milk in Russia, highlighting its multidrug resistance and the presence of various AMR genes including beta-lactamases and efflux pumps.
Identification and whole-genome sequencing analysis of Vibrio vulnificus strains causing pearl gentian grouper disease in China.
The study identified Vibrio vulnificus EPL 0201 biotype 2 as a multidrug-resistant strain with high pathogenicity, possessing virulence factors vvhA, rtxA, and wza, as well as resistance genes such as H-NS, TEM-1, sul1, tet, floR, parE, mprF, APH(6)-Id, APH(3'')-Ib, aadA16, and arr-3.
Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin.
The study identified several AMR genes in Akkermansia muciniphila strains, including adeF, tetW, sul2, and aph(6)-Id. Only the strain Amap1 showed resistance to tetracycline due to the presence of tetW. The presence of ARGs does not always translate into a resistant phenotype.
Case Report: The effect of intravenous and oral antibiotics on the gut microbiome and breath volatile organic compounds over one year.
The study identified several resistance genes in Bacteroides coprophilus and Bacteroides dorei, including adeF, ermF, tetQ, ermG, and a carbapenem resistance gene, highlighting the impact of antimicrobial exposure on the gut microbiome's resistance profiles.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
Whole-genome sequencing of Alcaligenes sp. strain MMA: insight into the antibiotic and heavy metal resistant genes.
The study identified multiple antibiotic resistance genes in Alcaligenes sp. strain MMA, including those conferring resistance to fluoroquinolones, tetracyclines, beta-lactams, penams, and macrolides. Additionally, the strain exhibited resistance to multiple heavy metals such as Cd, Ni, Cu, and Zn.
Whole-Genome Sequencing of Pseudomonas koreensis Isolated from Diseased Tor tambroides.
The study identified five antibiotic resistance genes in Pseudomonas koreensis CM-01, including soxR, adeF, AbaQ, and FosA, which contribute to resistance against ampicillin, aztreonam, clindamycin, and cefoxitin.
Global Antimicrobial Resistance Gene Study of Helicobacter pylori: Comparison of Detection Tools, ARG and Efflux Pump Gene Analysis, Worldwide Epidemiological Distribution, and Information Related to the Antimicrobial-Resistant Phenotype.
The study identified 42 antimicrobial resistance genes (ARG) in Helicobacter pylori, including 16 related to single antibiotic class resistance and 26 related to multidrug resistance. Key genes include hp1181, copA, msbA, vanT, vanTr, mepA, and several RND efflux pumps. These genes were validated through multiple detection tools and curation processes.
Using 16S rDNA and metagenomic sequencing technology to analyze the fecal microbiome of children with avoidant/restrictive food intake disorder.
The study identified several antibiotic resistance genes in the fecal microbiome of children with ARFID, including vanT, tetQ, adeF, and ermF, with ermF showing significantly higher abundance in the ARFID group compared to healthy controls.
Complete genome sequence of Bordetella parapertussis strain 400431-b, isolated from a protracted course of whooping cough in Austria, 2023.
The study reports the complete genome sequence of Bordetella parapertussis strain 400431-b, highlighting the presence of the beta-lactamase gene blaBOR-1 and two efflux pump genes, adeF and qacG, which correlate with elevated MICs for trimethoprim-sulfamethoxazole, erythromycin, and clarithromycin compared to strain FR6242.
Effects of Neolamarckia cadamba leaves extract on microbial community and antibiotic resistance genes in cecal contents and feces of broilers challenged with lipopolysaccharides.
The study found that Neolamarckia cadamba leaves extract (NCLE) reduced the abundance of antibiotic resistance genes (ARGs) in cecal contents of lipopolysaccharide (LPS)-induced broilers by maintaining microbial balance.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Impact of low-dose ozone nanobubble treatments on antimicrobial resistance genes in pond water.
Low-dose ozone nanobubble treatments increased the relative abundance of antimicrobial resistance genes (ARGs) in pond water, particularly those associated with efflux pumps and beta-lactam resistance.
Viral and thermal lysis facilitates transmission of antibiotic resistance genes during composting.
The study reveals that composting increases the proportion of extracellular antibiotic resistance genes (eARGs) due to viral and thermal lysis of bacteria, posing a transmission risk through horizontal gene transfer.
Genomic Analysis of Cronobacter condimenti s37: Identification of Resistance and Virulence Genes and Comparison with Other Cronobacter and Closely Related Species.
The study identified 17 antimicrobial resistance genes in Cronobacter condimenti s37, including genes involved in resistance to multiple antibiotic classes such as beta-lactams, tetracyclines, macrolides, phenicols, quinolones, aminoglycosides, glycopeptides, peptide antibiotics, rifamycins, nitroimidazoles, phosphonic acid derivatives, diaminopyrimidine derivatives, and elphamycins.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
Investigating the resistome of haemolytic bacteria in Arctic soils.
The study identified multiple AMR genes in Arctic haemolytic bacteria, including genes encoding efflux pumps and ribosomal protection proteins, indicating the presence of resistance mechanisms against various antibiotics.
Detection and Whole-Genome Characteristics of Bordetella trematum Isolated from Captive Snakes.
The study identified three AMR genes in Bordetella trematum isolates from captive snakes: tmexD4, adeF, and fosA8, which confer resistance to tetracyclines, fluoroquinolones/tetracyclines, and fosfomycin, respectively.
Comparative phenotypic and genotypic antimicrobial susceptibility surveillance in Achromobacter spp. through whole genome sequencing.
The study identifies multiple AMR genes in Achromobacter spp., including RND-type efflux pumps and various beta-lactamases, which contribute to resistance against multiple antibiotics.
Alistipes Bacteremia in Older Patients with Digestive and Cancer Comorbidities, Japan, 2016-2023.
The study identified several antimicrobial resistance genes in Alistipes strains, including adeF, tet(Q), cfxA3, cfxA4, and ermG, which confer resistance to various antibiotics such as minocycline, cefuroxime, and clindamycin.
Genomic and Virulence Characteristics of Brucella intermedia Isolated from Hospital Wastewater in Ghana.
The study identified the first report of trimethoprim-sulfamethoxazole resistance in Brucella intermedia, along with the presence of AMR genes such as ANT(9)-Ic and adeF.
Genomic and phenotypic characterization of six multidrug-resistant Acinetobacter pittii isolates.
The study identified multiple beta-lactamase genes, including blaOXA-72, blaOXA-272, and blaOXA-255, which confer resistance to carbapenems. Additionally, other resistance genes such as blaADC-245, blaADC-150, and others were found to confer resistance to cephalosporins. Efflux pump genes like adeF, abaQ, and abeS were associated with resistance to fluoroquinolones and tetracyclines. The gene lpsB was linked to colistin resistance.
Metagenomics reveals fibre fermentation and AMR pathways in red grouse (Lagopus scotica) microbiota.
The study identified multiple vancomycin resistance genes, including vanW, vanG, vanT, vanY, vanXY, vanH, and others, in the caecal microbiota of red grouse. Additionally, a tetracycline resistance gene (adeF) and a metronidazole resistance gene (nimJ) were detected.
Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.
The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
The study identifies several AMR genes and mutations in the novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate BB-7, including bla CTX-M-15, bla SHV-28, bla TEM-1, bla OXA-1, bla OXA-232, armA, aadA2, baeR, tetD, adeF, emrR, AAC(6')-Ib-cr6, catI, sul1, mphE, msrE, dfrA1, oqxA, and fosA, as well as mutations in GyrA, ParC, OmpA, OmpK37, and ArnT that confer resistance to multiple antibiotics.
Genomic characterization of an environmental Burkholderia thailandensis strain from Kerala, India reveals virulence and antimicrobial resistance signatures.
The study identifies multiple antimicrobial resistance genes in an environmental Burkholderia thailandensis strain, including efflux pumps and a β-lactamase, suggesting potential multidrug resistance.
Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistant Klebsiella pneumoniae from human and animal hosts in Central China.
The study identifies multiple AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates from human and animal hosts in Central China, highlighting the role of plasmid-borne resistance genes and genetic variations affecting virulence.
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