adeH

resistance-nodulation-cell division (RND) antibiotic efflux pump

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: overexpression studies
Drug Classes: tigecycline
Organisms: Acinetobacter baumannii AYE, Acinetobacter baumannii
Papers: 1
Databases: Card DatabaseReslit

Papers1

PMID N/A

Gene Information

Gene Name: adeH
Allele: adeH
Encodes: resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Acinetobacter baumannii AYE
Sequence Accession: CT025802.2
Protein Accession: CAJ77855.1
Notes: ARO:3000779

Resistance mechanisms of tigecycline in Acinetobacter baumannii.

PMID 37228666 · 2023

The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.

Gene Information

Gene Name: adeH
Allele: adeH
Encodes: outer membrane protein
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: tigecycline
Organisms Tested In: • Acinetobacter baumannii
Validation Method: overexpression studies

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