ahpF

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peroxiredoxin reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ahpF

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Validation StatusCandidate

Overview

Mechanism: activates 5-nitrofurans
Validation Method: genomic sequencing, genetic, biochemical, and bioinformatic approaches
Drug Classes: furazolidone, nitrofurantoin, polymyxins
Organisms: Escherichia coli, Klebsiella pneumoniae
Papers: 2
Databases: Reslit

Papers2

Novel 5-Nitrofuran-Activating Reductase in Escherichia coli.

PMID 31481448 · 2019

Gene Information

Gene Name: ahpF
Allele: ahpF
Encodes: peroxiredoxin reductase
Source Database: Reslit
Mechanism: activates 5-nitrofurans
Confers Resistance To: furazolidonenitrofurantoin
Organisms Tested In: • Escherichia coli
Validation Method: genomic sequencing, genetic, biochemical, and bioinformatic approaches

Predicting Phenotypic Polymyxin Resistance in Klebsiella pneumoniae through Machine Learning Analysis of Genomic Data.

PMID 32457240 · 2020

The study identifies several genes associated with polymyxin resistance in Klebsiella pneumoniae using machine learning analysis of genomic data, including known resistance determinants and potential novel genes.

Gene Information

Gene Name: ahpF
Allele: ahpF
Encodes: alkyl hydroperoxide reductase subunit F
Source Database: Reslit
Confers Resistance To: polymyxins
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: machine learning model interpretation

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ahpF

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ahpF

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