aldB

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Aldehyde dehydrogenase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aldB

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: Upregulates ampH expression, reducing β-lactam resistance
Validation Method: Gene knockout and MIC testing
Drug Classes: carbenicillin, cefalotin, cefoxitin, cefuroxime, cefotaxime, ceftazidime, cefepime, aztreonam
Organisms: Phytobacter diazotrophicus
Papers: 1
Databases: Reslit

Papers1

Regulatory relationships among aldB, ampH, and acoR and their impact on β-lactam susceptibility in Phytobacter diazotrophicus.

PMID 41311497 · 2025

The study identifies aldB, ampH, and acoR as key regulators of β-lactam resistance in Phytobacter diazotrophicus, demonstrating that aldB and acoR reduce resistance by upregulating ampH and aldB expression, respectively.

Gene Information

Gene Name: aldB
Allele: aldB
Encodes: Aldehyde dehydrogenase
Source Database: Reslit
Mechanism: Upregulates ampH expression, reducing β-lactam resistance
Confers Resistance To: carbenicillincefalotincefoxitincefuroximecefotaximeceftazidimecefepimeaztreonam
Organisms Tested In: • Phytobacter diazotrophicus
Validation Method: Gene knockout and MIC testing
Sequence Accession: PRJNA1298522

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aldB

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aldB

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