algC

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UDP-glucose pyrophosphorylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to algC

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: knockout and complementation experiments with MIC testing
Drug Classes: amoxicillin, tetracycline, clarithromycin, metronidazole, levofloxacin, rifampicin
Organisms: Helicobacter pylori
Papers: 1
Databases: Reslit

Papers1

Role of AlgC and GalU in the Intrinsic Antibiotic Resistance of Helicobacter pylori.

PMID 37016632 · 2023

AlgC and GalU are crucial for the intrinsic antibiotic resistance of H. pylori by maintaining the lipid A-core structure and reducing membrane permeability. Their knockout increases susceptibility to multiple antibiotics.

Gene Information

Gene Name: algC
Allele: algC
Encodes: UDP-glucose pyrophosphorylase
Source Database: Reslit
Confers Resistance To: amoxicillintetracyclineclarithromycinmetronidazolelevofloxacinrifampicin
Organisms Tested In: • Helicobacter pylori
Validation Method: knockout and complementation experiments with MIC testing

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algC

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algC

Gene Information