algZ

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alginate biosynthesis protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to algZ

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: mutation leading to increased antibiotic resistance
Validation Method: whole-genome sequencing and MIC testing
Drug Classes: ceftazidime
Organisms: Pseudomonas aeruginosa
Geographic Location: Europe
Papers: 1
Databases: Reslit

Papers1

Acidic Microenvironment Determines Antibiotic Susceptibility and Biofilm Formation of Pseudomonas aeruginosa.

PMID 34867864 · 2021

The study shows that acidic pH increases antibiotic tolerance and resistance in Pseudomonas aeruginosa, primarily through mutations in efflux pump genes (mexB, mexR) and other genes involved in biofilm formation and virulence.

Gene Information

Gene Name: algZ
Allele: algZ
Encodes: alginate biosynthesis protein
Source Database: Reslit
Mechanism: mutation leading to increased antibiotic resistance
Confers Resistance To: ceftazidime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe
Validation Method: whole-genome sequencing and MIC testing
Sequence Accession: NCBI Sequence Read Archive (SRA)|PRJNA685187

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algZ

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algZ

Gene Information