Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
sensor component of the AmgRS two-component system
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R182C | - | gain-of-function mutation that activates the AmgRS two-component system, two-component system sensor histidine kinase AmgS | Pseudomonas aeruginosa | tobramycin|gentamicin|amikacin|paromomycin|neomycin|streptomycinamikacin|tobramycin | ReslitReference Gene Catalog | Candidate |
| A203V | - | mutations in the linker domain of AmgS, the closest Escherichia coli homolog of AmgS, often cause activation of the kinase sensor | Pseudomonas aeruginosa | aminoglycosides | Reslit | Candidate |
| P116L | - | mutations in the sensor domain of AmgS, where mutations involved in aminoglycoside resistance have been previously described | Pseudomonas aeruginosa | aminoglycosides | Reslit | Candidate |
| C28A | - | - | Pseudomonas aeruginosa | tobramycin | Reslit | Candidate |
| E108Q | - | - | Pseudomonas aeruginosa | amikacin | Reslit | Candidate |
| V121G | - | increased mexXY expression, two-component system sensor histidine kinase AmgS | Pseudomonas aeruginosa | tobramycin|gentamicin|amikacinamikacin|tobramycin | ReslitReference Gene Catalog | Candidate |
| W120G | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| P435A | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| P381S | - | two-component system sensor histidine kinase AmgS | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.
The R182C mutation in amgS was shown to activate the AmgRS two-component system, leading to increased resistance to aminoglycosides.
amgS
Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.
Transcriptional and Mutational Profiling of an Aminoglycoside-Resistant Pseudomonas aeruginosa Small-Colony Variant.
The predictive potential of different molecular markers linked to amikacin susceptibility phenotypes in Pseudomonas aeruginosa.
Gene-Gene Interactions Reduce Aminoglycoside Susceptibility of Pseudomonas aeruginosa through Efflux Pump-Dependent and -Independent Mechanisms.
Increases MIC by 2-fold
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.
missense mutation
AmgRS-mediated envelope stress-inducible expression of the mexXY multidrug efflux operon of Pseudomonas aeruginosa.
amgS
A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical Pseudomonas aeruginosa.
amgS
[Overview of the Swiss Red Cross service activities in professional education].
amgS