amiE

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oligopeptide transporter

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to amiE

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Validation StatusCandidate

Overview

Mechanism: inhibition triggers tolerance
Validation Method: knockout in S. pneumoniae + antibiotic accumulation analysis
Drug Classes: ciprofloxacin, vancomycin, gentamicin
Organisms: Streptococcus pneumoniae
Papers: 1
Databases: Reslit

Papers1

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance.

PMID 35672367 · 2022

The study identified genes like cozEb and amiE/amiC that influence antibiotic sensitivity through various mechanisms, including cell wall synthesis and efflux pump inhibition, demonstrating the complexity of bacterial tolerance and resistance.

Gene Information

Gene Name: amiE
Allele: amiE
Encodes: oligopeptide transporter
Source Database: Reslit
Mechanism: inhibition triggers tolerance
Confers Resistance To: ciprofloxacinvancomycingentamicin
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: knockout in S. pneumoniae + antibiotic accumulation analysis

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amiE

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amiE

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