The study identifies MexAB-OprM efflux system and AmpC beta-lactamase as key contributors to intrinsic penem resistance in Pseudomonas aeruginosa, along with the outer membrane barrier.

The study identifies a mutation in the Serratia marcescens AmpC beta-lactamase gene (Thr64→Ile) that leads to high-level resistance to ceftazidime and cefpirome. This mutation enhances the catalytic efficiency of the enzyme towards these antibiotics.

The study identifies mutations in the ampC promoter region leading to high-level expression of the AmpC beta-lactamase in E. coli clinical isolates, causing resistance to extended-spectrum cephalosporins.

The ampC gene from Acinetobacter baumannii strain RAN was cloned and shown to confer resistance to cephalothin, cefuroxime, and cefoxitin when expressed in E. coli.

Exposure of Pseudomonas aeruginosa biofilms to imipenem led to significant changes in gene expression, including a 67- to 150-fold induction of the ampC gene, which encodes the chromosomal beta-lactamase. Additionally, alginate biosynthesis genes were induced, resulting in increased alginate production.

The study identified AmpC hyperproduction as the primary mechanism of resistance to ceftazidime (CAZ) in Pseudomonas aeruginosa, both in vitro and in vivo. This resistance mechanism was observed in both wild-type and hypermutable strains, with increased beta-lactamase activity contributing to resistance against β-lactam antibiotics.

The study identified mutations in the oprD gene leading to reduced susceptibility to meropenem and overproduction of AmpC beta-lactamase contributing to resistance to ceftazidime in Pseudomonas aeruginosa strains.

The study identifies AmpC, GadA, and GadB as genes involved in epigenetic-based antibiotic resistance in E. coli, demonstrating that gene expression changes can lead to resistance without DNA mutations. Additionally, the DNA methyltransferase dam was found to influence resistance to nalidixic acid.

The study identified the presence of antibiotic resistance genes including tetO, ermB, mecA, blaSHV-5, ampC, and vanA in reclaimed water from three European artificial groundwater recharge systems. These genes were detected using real-time qPCR, indicating their potential impact on the environment.

The study identifies multiple genes and mutations that contribute to antibiotic tolerance in E. coli, revealing a large mutational target size for increasing drug resistance. Key findings include the role of genes involved in electron transport, flagella synthesis, and efflux pumps in modulating susceptibility to various antibiotics.

The study characterizes the chromosomal beta-lactamase gene ampC and its regulatory genes ampR, ampD, ampE, and ampG in various Gram-negative bacteria, highlighting their roles in cephalosporin resistance.

The study identified that ceftazidime-selected mutants overexpressed AmpC beta-lactamase, while ceftobiprole-selected mutants primarily exhibited upregulation of the mexXY efflux system. Cefepime-selected mutants showed variable resistance mechanisms including AmpC overexpression or mexXY upregulation.

The study identified ampC genes of DHA, EBC, and CIT types in Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens isolates, along with TEM, CTX-M-3-like, and SHV genes, demonstrating their roles in conferring resistance to various beta-lactam antibiotics.

The study identified several AMR genes in Acinetobacter baumannii, including blaOXA-69, which confers resistance to carbapenems, and AdeT, an RND-type efflux pump involved in aminoglycoside resistance. AmpC cephalosporinase was also found to contribute to resistance against cephalosporins.

The study identifies several β-lactam resistance genes, including ampC, lacA, pbp2, pbp3, pbp4a, pbp6a, and pbp7, as well as multidrug efflux pumps such as acrAB-tolC, acrAD-tolC, mdtABC-tolC, emrAB-tolC, mexAB-oprM, and others. Additionally, genes like bacA, ksgA, crcB, and rarD are implicated in resistance to bacitracin, kasugamycin, streptomycin, camphor, and chloramphenicol, respectively.

The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.

The study identifies several AMR genes in Pseudomonas aeruginosa M18, including beta-lactamase ampC and efflux pumps mexAB-oprM, mexCD-oprJ, and mexEF-oprN, which confer resistance to various antibiotics. The strain M18 is more susceptible to certain antimicrobials compared to LESB58.

The study identifies the hyperproduction of the chromosomal cephalosporinase AmpC and the inactivation of the OprD porin as the primary mechanisms of multidrug resistance in a Pseudomonas aeruginosa outbreak.

The study identified several antibiotic resistance genes, including tetB(P), aadA5, ampC, macB, IS Pps1, and IS Sm2, in the plasmid metagenome of activated sludge, highlighting the presence of diverse resistance mechanisms in environmental microbial communities.

AmpR is a global regulator in P. aeruginosa that influences the expression of over 500 genes, including those involved in β-lactam resistance, virulence, and biofilm formation.

The study identifies genetic markers of extensive drug-resistant Pseudomonas aeruginosa high-risk clones, including ampC hyperproduction, oprD inactivation, aadB gene production, and mexZ mutations, along with specific mutations in ampR, gyrA, and parC that contribute to resistance.

The study identified several AMR genes in Morganella morganii KT, including ampC, metallo-beta-lactamase genes (MM2254, MM2308, MM2606), tetAJ, catA2, bcr, and ksgA, which confer resistance to various antibiotics such as beta-lactams, carbapenems, tetracycline, chloramphenicol, bicyclomycin, and kasugamycin.

The study identifies ampC beta-lactamase overexpression as a mechanism of resistance to BAL30072 in Pseudomonas aeruginosa, along with the involvement of the FecIRA Fe-dicitrate transporter and PiuA iron receptor in susceptibility.

The study identifies ampC as a gene that confers amoxicillin resistance through a promoter mutation leading to increased beta-lactamase activity in Escherichia coli.

The study identifies mpl and nuoN as novel genes responsible for the overexpression of ampC in Pseudomonas aeruginosa PAO1, leading to increased resistance to β-lactam antibiotics.

The study identified ampC as a gene regulated by AmpR, which encodes a beta-lactamase that confers resistance to cephalosporins in Pseudomonas aeruginosa.

The study identifies AmpR and AmpC as key regulators in β-lactam and non-β-lactam transient cross-resistance in Pseudomonas aeruginosa upon pre-exposure to subinhibitory concentrations of antibiotics.

The study reports the emergence of Escherichia coli producing extended-spectrum AmpC beta-lactamases (ESAC) in animals, highlighting the identification of specific mutations in the ampC gene that confer resistance to cephalosporins.

The study identifies mutations in the ampC gene of Pseudomonas aeruginosa that lead to overexpression and structural modifications of AmpC, contributing to resistance against ceftolozane-tazobactam and ceftazidime.

The study identifies mutations in the ampC promoter region leading to amoxicillin resistance and mutations in gyrA and parC contributing to enrofloxacin resistance in E. coli.

The study identifies the presence of the ampC gene encoding a beta-lactamase and the ermG gene encoding a ribosomal methyltransferase in the multiple antibiotic-resistant Enterobacter cloacae strain F3S3, which confers resistance to penicillin and erythromycin respectively.

The study identified the sul1 gene duplication as a mechanism for sulfamethoxazole resistance in the spaceflight mutant strain LCT-KP289. Additionally, the ampC, emrE, and ant genes were found to contribute to drug resistance in both strains.

The study identified ampC derepression and oprD loss as the primary mutation-driven resistance mechanisms in ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals.

The study identifies multiple AMR genes and mutations in the multi-resistant P. aeruginosa isolate PA49, including aac(6')-Ib, aadB, blaVIM-2, ampC, and mutations in gyrA, parC, and oprD, which confer resistance to various antibiotics.

The study identified mutations in the AmpC gene of DHA-1 plasmid-mediated Klebsiella pneumoniae isolates, which contribute to β-lactam resistance.

The study compares label-free SRM-based mass spectrometry with RT-qPCR for quantifying antibiotic resistance mechanisms in Pseudomonas aeruginosa, focusing on efflux pumps, AmpC beta-lactamase, and OprD porin. SRM showed superior accuracy in classifying efflux pump overexpression and predicting resistance.

The study characterizes the resistance genetic determinants of the hypervirulent Acinetobacter baumannii strain LAC-4, identifying multiple beta-lactamases, aminoglycoside modifying enzymes, and RND-type efflux pumps contributing to its multidrug resistance.

The study detected plasmid-mediated AmpC beta-lactamase-producing Klebsiella pneumoniae isolates in Tehran hospitals, highlighting the low prevalence of AmpC producers and the limitations of phenotypic methods for detection.

Mutations in ampD in Burkholderia cenocepacia lead to the coregulation of AmpC and PenB beta-lactamases, conferring resistance to ceftazidime, cefotaxime, and meropenem.

The study identifies that phosphorylation of AmpC beta-lactamase at Ser-90 regulates its activity and affects imipenem resistance in Acinetobacter baumannii SK17.

The study identifies that phosphorylation of AmpC β-lactamase at Ser-90 regulates its activity and affects imipenem resistance in Acinetobacter baumannii SK17.

PAHM4 exhibits resistance to multiple antibiotics, including β-lactams, aminoglycosides, and fluoroquinolones, due to mutations in genes such as ampC, creD, mexB, gyrA, parC, and parE, as well as a mutS mutation leading to hypermutation.

The study identifies multiple AMR genes and mutations in Pseudomonas aeruginosa, including aadA1, aadA6, aacA4, aacA7, aacA5, blaOXA-2, blaOXA-4, blaVIM-1, blaVIM-2, blaGIM-2, blaIMP-1, blaIMP-7, blaPER-1, blaCTX-M-3, ampC, gyrA (T83I), and parC (S87L/W), which are associated with resistance to various antibiotics such as tobramycin, ceftazidime, meropenem, and ciprofloxacin.

The study identified several antibiotic resistance genes, including ampC, tet(A), and mecA, in water samples from a First Nations community in Canada, highlighting concerns about water quality and potential health risks.

The paper discusses the mechanisms of antibiotic resistance in Burkholderia species, focusing on β-lactam resistance mediated by penA, penB, and ampC beta-lactamases, as well as efflux pumps like AmrAB-OprA, BpeAB-OprB, and BpeEF-OprC. It also highlights mutations in penA and gyrA that contribute to resistance against β-lactam and fluoroquinolone antibiotics.

The study identifies Saccharomyces cerevisiae IFST 062013 as a potential probiotic with resistance to tetracycline, ampicillin, gentamicin, penicillin, polymyxin B, and nalidixic acid.

The study identified Metallo-β-Lactamase (MBL) and Amp C β-lactamase production in Pseudomonas aeruginosa isolates from Egypt, highlighting the prevalence of carbapenem resistance and multidrug resistance.

The study identifies several AMR genes and mutations associated with multidrug-resistant Klebsiella pneumoniae in the UK and Ireland, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and mutations in gyrB contributing to fluoroquinolone resistance.

Indole induces ampicillin resistance in Pseudomonas putida KT2440 and P. aeruginosa PAO1 through the upregulation of ampC, encoding a beta-lactamase, and RND-type efflux pumps.

The study identified various antimicrobial resistance genes in STEC isolates from cattle, including ampC, blaTEM, tetE, tetB, and tetC, which confer resistance to beta-lactams and tetracyclines. These findings highlight the importance of monitoring antimicrobial resistance in STEC strains.

TCDD exposure leads to an increase in antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in the murine gut microbiome, particularly in Enterobacteriaceae, with specific genes like blaCMY2, ampC, and various MDR genes being significantly enriched.

The study identifies that the quorum-sensing signaling molecule N-3-OH-C12-HSL induces the expression of drug-resistance genes OXA-51, AmpC, AdeA, and AdeB in Acinetobacter baumannii, enhancing resistance to meropenem.

The study identified multiple antimicrobial resistance genes in the multidrug-resistant, heat-resistant E. coli strain FAM21845, including beta-lactamase blaTEM-1, aminoglycoside resistance genes strA, strB, aadA1, aph(3')-Ic, aph(4)-Ia, aac(3)-IVa, sulfonamide resistance gene sul1, trimethoprim resistance gene dfrA1, tetracycline resistance gene tet(B), disinfectant resistance gene qacEΔ1, and biofilm-related genes mrkABCDF. Additionally, the strain carried genes for resistance to arsenic, silver, and copper.

The study identified various AMR genes and mutations in extensively drug-resistant Pseudomonas aeruginosa isolates from Spain, including beta-lactamases, aminoglycoside-modifying enzymes, and mutations in genes such as ampC, oprD, gyrA, parC, mexZ, and glpT, which contribute to resistance against multiple antibiotics.

The study identifies several beta-lactamases and efflux pumps contributing to antibiotic resistance in Burkholderia cenocepacia, highlighting the complexity of its resistance mechanisms.

Four multidrug resistance plasmids were captured from the sediments of an urban coastal wetland. These plasmids carried various resistance genes, including beta-lactamases, tetracycline resistance genes, sulfonamide resistance genes, and others, conferring resistance to multiple antibiotics.

The study identifies several genes whose overexpression leads to increased resistance to various antibiotics in E. coli, including ftsI, ampC, nlpE, marC, rob, soxS, sdiA, folA, and yebV.

The study demonstrates the successful detection of antimicrobial resistance-associated proteins using TiO2-facilitated MALDI-TOF MS without sample pre-treatment. Specific resistance proteins such as blaTEM-1, aacC1, cat, and ampC were identified in various bacterial strains.

The study identifies several P. aeruginosa genes that are induced during human infections and are associated with antibiotic resistance mechanisms, including efflux pumps, beta-lactamases, and other resistance determinants.

The study characterizes the antibacterial spectrum of a tetrazole-based reversible inhibitor of serine beta-lactamases, showing significant activity against various CTX-M subtypes and other serine beta-lactamases, including CTX-M-9, CTX-M-14, CTX-M-15, CTX-M-27, SHV-2, KPC-2, AmpC, OXA-48, and TEM-1.

The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.

The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.

The study identifies numerous genes whose expression changes can confer resistance to various antibiotics, highlighting the role of nonoptimal gene expression in antibiotic resistance development.

The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.

The study shows that the expression of ampC and ampG genes in E. coli O157:H7 contributes to radioresistance, particularly when the bacteria are adapted to carbenicillin. Mutants lacking these genes showed increased sensitivity to irradiation.

The study predicts antibiotic resistance in E. coli using machine learning models trained on pan-genome data, identifying key resistance genes such as bla-CTX-M, ampC, dfrA, qep, and oxa.

The study identifies ampC gene amplification as a mechanism for de novo amoxicillin resistance in E. coli, along with various deletions and insertions mediated by transposable elements.

The study identified multiple beta-lactamase genes, including bla CTX-M, bla CMY, bla TEM, and ampC, in intrauterine pathogenic E. coli (IUPEC) isolates from cows with metritis, which conferred resistance to cephalosporins like cefotaxime and ceftiofur.

The study identifies mutations in the ampC gene, specifically V213A and Δ7, as contributing to ceftolozane/tazobactam resistance in Pseudomonas aeruginosa. The V213A mutation increases beta-lactamase activity, while the Δ7 mutation does not.

The study identified the presence of antibiotic resistance genes (ARGs) including ampC, mecA, and sul1 in drinking water samples from First Nations communities in Manitoba, Canada, highlighting potential risks to water safety.

The study identifies several periplasmic proteins involved in antibiotic resistance in Acinetobacter baumannii AB5075, including the beta-lactamases AmpC, OXA-23, and GES-11, as well as the RND-type efflux pump AdeT. Additionally, a novel metal-dependent hydrolase, ABUW_0920, was identified, suggesting potential roles in beta-lactam resistance.

The study identified multiple AMR genes and mutations in E. coli ST131 isolates from a patient with recurrent UTIs, including plasmid-borne resistance genes and chromosomal mutations contributing to fluoroquinolone resistance.

The study found that β-lactam resistance genes, including ampC and arcA, were more abundant in postweaning heifers with a higher Brahman proportion.

The study identified bla CTX-M-15 as a key determinant of cephalosporin resistance in Klebsiella pneumoniae and Enterobacter cloacae, while Enterobacter cloacae relied on chromosomal ampC for intrinsic resistance.

The study identified resistance to ampicillin, sulfamethoxazole, and tetracycline in Salmonella isolates from a pig slaughterhouse, with no significant changes in resistance patterns after cleaning and disinfection procedures.

The study identifies a promoter mutation in the ampC gene leading to increased AmpC beta-lactamase production and resistance to amoxicillin-clavulanic acid in E. coli.

The study identifies several nonessential genes involved in β-lactam resistance in Pseudomonas aeruginosa, including ampC, mltG, mepM1, amgK, and ygfB, which contribute to the induction of ampC expression and resistance against meropenem and cefepime.

The study identified several AMR genes in E. coli isolates from pigeon meat, including ampC, aadA, cmlA, sul1, sul2, and sul3, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, and sulfonamides.

Overexpression of AmpC, a beta-lactamase, increases the susceptibility of ampicillin-resistant E. coli to phage lysis by promoting the expression of the phage receptor protein OmpA.

The study identified the presence of extended-spectrum beta-lactamase genes bla CTX-M-15, bla TEM-1B, bla OXA-1, and ampC in Enterobacteriaceae isolates from urban wetlands in Nigeria, highlighting the significant contamination of these environments with clinically relevant antimicrobial resistance genes.

The study identifies a 2-amino acid deletion in the R2 loop of AmpC beta-lactamase as the mechanism of ceftazidime-avibactam, cefepime, and cefiderocol resistance in Enterobacter hormaechei.

A two amino acid deletion in the R2 loop of AmpC β-lactamases in Enterobacter cloacae leads to reduced susceptibility to ceftazidime-avibactam and cefiderocol due to structural changes enhancing hydrolysis of these antibiotics.

The study identified several AMR genes in E. coli isolates from meat in South Africa, including aadA, strA, aph(3)-Ia, aph(3)-IIa, aac(3)-IIa, blaTEM, blaZ, ampC, cat1, cat2, cmlA1, sul1, sul2, tetA, tetB, tetC, tetD, and tetM, which confer resistance to various antibiotics such as streptomycin, kanamycin, neomycin, gentamicin, amoxicillin, ampicillin, chloramphenicol, cotrimoxazole, and tetracycline.

The study identifies that the carbapenem resistance in IRP41 is primarily due to the ampC hyper-expression and an inactive OprD caused by a G831A substitution. Additionally, a frameshift mutation in ldcA leads to increased ampC expression, contributing to resistance.

The study identifies ampC beta-lactamase from Morganella morganii as a key player in beta-lactam resistance and predicts OncoglabrinolC as a potential inhibitor through computational and experimental methods.

Mutations in the ampC gene of Pseudomonas aeruginosa enhance resistance to ceftolozane and ceftazidime by increasing catalytic efficiency and reducing avibactam inhibition.

The study identified several antimicrobial resistance genes in Campylobacter species isolated from retail fresh milk and water samples, including catII, tetA, tetB, tetM, ermB, gyrA, ampC, and aac(3)-IIa-(aacC2). These genes were associated with resistance to chloramphenicol, tetracycline, erythromycin, gentamicin, and ampicillin.

This review discusses the mechanisms that protect Acinetobacter baumannii against multiple stresses, including those from the host immune response, antibiotics, and the outside environment. It highlights the role of surface glycoconjugates, outer membrane components, and various virulence factors in evading immune defenses and surviving adverse conditions.

The study identified various extended-spectrum beta-lactamase (ESBL) and ampC beta-lactamase genes, including bla TEM, bla SHV, bla CTX-M, bla OXA-1, and ampC, in Escherichia coli isolates from imported 1-day-old poultry. These genes conferred resistance to multiple beta-lactam antibiotics.

RBX2660 introduced antibiotic-resistant organisms (AROs) with various resistance genes, including AmpC, TEM-1, CARB, and CTX-M-14, which conferred resistance to multiple antibiotics.

The study identified blaTEM, AmpC, qnrS, merB, merP, merT, silE, silP, silS, arsC, IntI, SulI, ISecp1, TN3, and TN21 as significant AMR genes in bacterial isolates from Dal and Wular Lakes in Kashmir, India. These genes were found to confer resistance to various antibiotics and heavy metals, highlighting the co-existence of antibiotic and metal resistance determinants in aquatic environments.

The study identified several AMR genes and mutations in Acinetobacter baumannii, including beta-lactamases like blaOXA-23, blaOXA-64, and blaOXA-235, as well as aminoglycoside resistance genes like aadA1 and AAC(3)-Ia. It also found a gyrA S82L mutation associated with quinolone resistance.

The study identified various carbapenemase genes, including blaNDM-5, blaNDM-1, blaNDM-4, blaNDM-7, blaOXA-181, and blaOXA-48, along with extended-spectrum beta-lactamase CTX-M-15, ampC beta-lactamase CMY-42, and penicillinases TEM-1B and OXA-1 in carbapenem-non-susceptible Escherichia coli isolates from Oman.

The study identified the presence of the AmpC beta-lactamase gene in a multidrug-resistant strain of Klebsiella pneumoniae and demonstrated that the crude ethyl extract of Andrographis paniculata could suppress the expression of this gene, thereby reducing resistance to certain beta-lactam antibiotics.

The study identified extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producing gram negative bacilli, primarily Escherichia coli and Klebsiella pneumoniae, with high rates of multidrug resistance. Key ESBLs identified include blaCTX-M, blaSHV, and blaTEM, while ampC was found in E. coli, K. pneumoniae, and Citrobacter spp.

The study identifies multiple mechanisms of resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa, including the production of extended-spectrum beta-lactamases (ESBLs) and carbapenemases, overproduction of the intrinsic cephalosporinase PDC, and mutations in regulatory and peptidoglycan recycling genes.

NagZ enhances resistance to β-lactam antibiotics in Enterobacter cloacae by promoting the expression of chromosomal AmpC beta-lactamase.

The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.

The study identified antibiotic resistance genes ampC, aadB, and mphA in E. coli isolates from diarrheic camel neonates in Egypt, indicating multidrug resistance.

The study investigated the molecular basis of AmpC beta-lactamase induction by avibactam in Pseudomonas aeruginosa, focusing on the relationship between PBP4 inhibition and ampC induction. It identified specific mutations in AmpC (E247K and DelG229-E247) that reduced susceptibility to avibactam and increased resistance to ceftolozane and ceftazidime.

The study identified multiple antibiotic resistance genes in Shiga toxin-producing E. coli (STEC) isolates, including aadA1, aac(3)-I, ere(A), ampC, blaSHV, blaCMY, and tet(A), which conferred resistance to various antibiotics such as streptomycin, gentamicin, erythromycin, ampicillin, penicillin, cephalosporin, and tetracycline.

The study identified several AMR genes, including blaCTX-M, mcr-1, and qnrS1, which confer resistance to cephalosporins, colistin, and fluoroquinolones, respectively, in commensal E. coli from various sources.

The study identified variable expression of the AmpC beta-lactamase gene in multidrug-resistant clinical isolates of Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterococcus faecium, contributing to resistance against β-lactam antibiotics.

The study highlights the widespread presence of Campylobacter spp. in duck-related isolates and reports high resistance rates to fluoroquinolones, tetracycline, and other antibiotics. It emphasizes the need for improved surveillance and control measures to address antimicrobial resistance in Campylobacter.

The study identified blaKPC-2, blaNDM-1, mcr-4.3, ecr, ampC, blaCTX-M-14, blaCTX-M-9, blaSHV, and blaTEM as genes contributing to carbapenem and colistin resistance in Enterobacter cloacae Complex strains.

The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.

Exposure to amoxicillin leads to multiplication of the chromosomal ampC gene, resulting in a transferable transposon in E. coli. This transposon can be transferred between E. coli cells via transformation.

The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.

The study identified a mutation in ampD leading to hyperproduction of AmpC beta-lactamase in Cedecea davisae, resulting in resistance to beta-lactam antibiotics.

The study identifies 12 antibiotic resistance genes in the draft genome of Cupriavidus pauculus strain MF1, including genes encoding beta-lactamases, efflux pumps, and a colistin resistance determinant. The isolate shows resistance to meropenem, amoxicillin, amikacin, gentamicin, and colistin, but susceptibility to cefotaxime, cefepime, imipenem, and ciprofloxacin.

The study identified several AMR genes and mutations in ertapenem-non-susceptible Enterobacterales, including carbapenemases (NDM-5, OXA-181), beta-lactamases (TEM-1B, CTX-M-71), and mutations in PBP3 and porin genes (ompC, ompF) that contribute to resistance against cefepime/taniborbactam and other beta-lactam antibiotics.

The study evaluated the combination of flomoxef and fosfomycin for treating neonatal sepsis in settings with high antimicrobial resistance. It found that the combination showed synergy in bacterial killing and prevented the emergence of fosfomycin resistance. Specific AMR genes and mutations were identified in Enterobacterales strains, including beta-lactamases and efflux pumps.

The study identified and characterized beta-lactamase genes (ampC, blaSHV, and blaTEM) in marine enterobacteria from the Upper Gulf of Thailand, highlighting their role in resistance to β-lactam antibiotics such as ampicillin and ticarcillin.

The study identified various AMR genes and mutations in clinical Acinetobacter pittii strains, including aminoglycoside-modifying enzyme ant(3'')-IIa, beta-lactamases ampC and blaOXA-213, blaOXA-325, and blaOXA-58, as well as point mutations in gyrA, parC, pmrA, pmrB, and lpxA associated with resistance to ciprofloxacin and colistin.

The study identified various AMR genes and mutations in gram-negative rods isolated from inanimate surfaces of hospital facilities, highlighting the presence of resistance mechanisms such as beta-lactamases, ESBLs, Qnr, OXA-48, and MBL.

The study shows that overproduction of the chromosomal ampC beta-lactamase gene maintains resistance to cefazolin in E. coli isolates, and mutations in the ampC attenuator regions contribute to this resistance.

The study identifies the presence of antibiotic resistance genes such as ampC and acrA in feral swine, cattle, soil, and water samples, highlighting the potential transmission of antibiotic resistance at the wildlife-livestock interface.

The paper reviews mechanisms of cefiderocol resistance, highlighting the roles of beta-lactamases (NDM, KPC, OXA-427, PER, SHV, BEL, AmpC), mutations in siderophore receptors (piuA, piuD, pirA, cirA, fiu), porins (ompK35, ompK36, ompK37, ompC, ompF), efflux pumps (mexAB-oprM, smeDEF, axyABM), and target modifications (pbp3).

The study identifies various genes and mutations associated with resistance to tobramycin, ceftazidime, and ceftazidime-avibactam in Pseudomonas aeruginosa, highlighting the impact of environmental conditions on the evolution of antibiotic resistance.

The study identifies the ampC gene as responsible for ampicillin resistance in E. coli, demonstrating that the AmpC-producing strain exhibits distinct volatile organic compound (VOC) profiles compared to the susceptible strain.

The study developed an SS CZA medium for screening CZA-resistant CRE isolates, demonstrating 100% sensitivity and specificity. The medium effectively distinguishes between CZA-resistant and -susceptible strains, with resistance determinants including blaNDM, blaKPC, blaCTX-M, blaTEM, blaSHV, blaOXA-23, blaIMP, and ampC.

The study identified various antimicrobial resistance genes in E. coli and Salmonella Typhi isolates from Brazilian swine slaughterhouses, including ampC, blaSHV, cat1, clmA, MCR-1, MCR-3, tet(A), tet(B), tet(C), tet(M), and sulI. These genes conferred resistance to multiple antibiotics such as ampicillin, amoxicillin, chloramphenicol, tetracycline, doxycycline, colistin, and sulfonamide.

Complex antibiotic environments drive the evolution of latent novel traits in E. coli through the spread of pleiotropic mutations affecting multiple resistance mechanisms.

The study shows that the enzymatic activity of AmpC beta-lactamase is essential for the full virulence attenuation in Pseudomonas aeruginosa under peptidoglycan recycling impairment, while the biological cost of AmpC variants is similar to the wild-type enzyme.

The study reports the draft genome sequences of seven multidrug-resistant Escherichia coli strains isolated from river water, identifying various antibiotic resistance genes and mutations associated with resistance to multiple antibiotics.

The study highlights the role of mobile genetic elements, particularly insertion sequences (IS), in the acquisition and dissemination of antibiotic resistance in Acinetobacter species. IS elements can enhance the expression of intrinsic beta-lactamase genes, such as bla OXA-23, bla OXA-51, and ampC, leading to carbapenem and cephalosporin resistance. Additionally, IS elements can disrupt genes involved in antibiotic uptake, such as porins, and alter the expression of efflux pumps, contributing to multidrug resistance.

Citrobacter gillenii was identified as the causative agent of a fatal bacterial disease in Russian sturgeon. Resistance genes ampC, sul1, and floR were detected, conferring resistance to penicillin, trimethoprim/sulfamethoxazole, and florfenicol, respectively.

The study identified multiple antibiotic resistance genes in Vibrio species from freshwater samples in Southwest Nigeria, including sulI, sulII, ampC, blaOXA, blaPSE, tetA, tetE, strA, aacC2, and aphA1, highlighting the environmental spread of resistance genes.

The study identified that a single mutation in the ampC gene led to CAZ-AVI resistance in XDR P. aeruginosa, highlighting the importance of maintaining adequate drug concentrations to prevent resistance development.

The study validated the use of long-read whole-genome sequencing for detecting antimicrobial resistance genes and predicting antimicrobial susceptibility. Several beta-lactamase and carbapenemase genes were identified in various bacterial isolates, demonstrating their role in resistance to specific antibiotics.