Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Anhydro-N-acetylmuramyl tripeptide amidase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S5F | - | - | - | imipenem|meropenem | Reslit | Candidate |
| G148A | - | - | Pseudomonas aeruginosa | imipenem|meropenemceftazidime avibactam | Reslit | Candidate |
| D183Y | - | - | - | imipenem|meropenem | Reslit | Candidate |
| H157Y | - | increased basal ampC expression, 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | ceftolozane tazobactamimipenemceftazidime+1 more | ReslitReference Gene Catalog | Candidate |
| D135N | - | change in amino acid | Pseudomonas aeruginosa | beta lactams | Reslit | Candidate |
| V84X | - | loss of function | Enterobacter cloacae | cefoxitin|cefotaxime|cefepime|ertapenem|imipenem|meropenem | Reslit | Candidate |
| W95L | - | The Trp95Leu substitution was predicted to weaken ligand binding, likely affecting the positioning of the ligand in the active site. | Klebsiella aerogenes | ertapenem|imipenem|meropenem | Reslit | Candidate |
| R161H | - | The Arg161His substitution was predicted to weaken ligand binding, likely affecting the positioning of the ligand in the active site. | Klebsiella aerogenes | ertapenem|imipenem|meropenem | Reslit | Candidate |
| R345Q | - | - | Pseudomonas aeruginosa | cephalosporins|penicillin | Reslit | Candidate |
| A134V | - | - | - | ticarcillin|piperacillin|cefepime|ceftazidime|aztreonam | Reslit | Candidate |
| T139M | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | ticarcillin|piperacillin|cefepime|ceftazidime|aztreonamcephalosporins | ReslitReference Gene Catalog | Candidate |
| V10G | - | - | - | ceftazidime|cefepime|piperacillin|tazobactam | Reslit | Candidate |
| P41L | - | - | - | piperacillin|fluoroquinolones | Reslit | Candidate |
| I69T | - | - | - | meropenem | Reslit | Candidate |
| Q88L | - | - | - | ceftazidime | Reslit | Candidate |
| G100E | - | - | - | meropenem | Reslit | Candidate |
| C110G | - | - | - | fluoroquinolones | Reslit | Candidate |
| G116V | - | - | - | meropenem|ceftazidime | Reslit | Candidate |
| I117T | - | - | - | ceftazidime | Reslit | Candidate |
| G121E | - | - | - | meropenem|ceftazidime | Reslit | Candidate |
| G169C | - | - | - | fluoroquinolones | Reslit | Candidate |
| A18E | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| L37F | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| V39A | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| S44G | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| P46T | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| L63P | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| H68Y | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| H74P | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| L75P | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| R79G | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| S81P | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| S120L | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| I121S | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| R167S | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| F191C | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Burkholderia cenocepacia | cephalosporins | Reference Gene Catalog | Candidate |
| I113S | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Enterobacter cloacae | aztreonam avibactam | Reference Gene Catalog | Candidate |
| H36R | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Candidate |
| Q44Ter | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Candidate |
| E67Ter | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Candidate |
| H77Y | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Candidate |
| E108Ter | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Candidate |
| S114P | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Candidate |
| Q155Ter | - | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Candidate |
| - | - | Pseudomonas aeruginosa | ceftazidime avibactam|ceftolozane tazobactam | Reslit | Candidate | |
| S37R | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| D164A | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| H75Y | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| Y87* | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| P165S | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| W7* | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| R93P | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| W95* | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| E118* | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| F160* | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| R22H | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| I78N | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| I78S | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate | |
| Y127H | - | Pseudomonas aeruginosa | ceftazidime avibactam|imipenem relebactam | Reslit | Candidate | |
| L140R | - | - | cefotaxime|ceftazidime|cefepime | Reslit | Candidate |
Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi.
The study identifies 11 genes in Acinetobacter baylyi whose disruption leads to antibiotic hypersusceptibility, including genes involved in efflux pumps, peptidoglycan synthesis, and other metabolic pathways.
Characterization of β-lactamase genes and their regulatory mechanisms in Gram-negative bacteria
The study characterizes the chromosomal β-lactamase gene ampC and its regulatory genes ampR, ampD, ampE, and ampG in various Gram-negative bacteria, highlighting their roles in cephalosporin resistance.
Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates.
Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response.
The study identifies the role of the σ S stress response in ciprofloxacin-induced mutagenesis, highlighting the importance of ROS and stress response pathways in generating antibiotic-resistant mutants.
Prosthetic valve endocarditis caused by Pseudomonas aeruginosa with variable antibacterial resistance profiles: a diagnostic challenge.
The study identifies mutations in ampR, ampD, and oprD genes in Pseudomonas aeruginosa isolates causing prosthetic valve endocarditis, which are associated with variable resistance profiles to ceftazidime, piperacillin-tazobactam, and carbapenems.
Genome-Wide Mutation Scoring for Machine-Learning-Based Antimicrobial Resistance Prediction.
The study explores the use of PROVEAN scores for predicting antimicrobial resistance through machine learning, highlighting the importance of mutation scoring in improving model performance for pathogens like Pseudomonas aeruginosa, Citrobacter freundii, and Escherichia coli.
The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study.
The study identifies multiple mutations in genes such as ampD, deoR, wecA, rcsC, ompC, ompD, and phoE that contribute to antibiotic resistance in Enterobacter hormaechei. These mutations include transposon insertions, deletions, and frameshift variants, leading to resistance against β-lactams, carbapenems, and other antibiotics.
In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia.
The study identifies a novel deletion in ampD and ampE associated with cefepime resistance and a porin mutation in oprD linked to carbapenem resistance in Pseudomonas aeruginosa during treatment.
Emergence of cefiderocol resistance during ceftazidime/avibactam treatment caused by a large genomic deletion, including ampD and piuCD genes, in Pseudomonas aeruginosa.
The study reports the emergence of cefiderocol resistance in Pseudomonas aeruginosa due to a large genomic deletion encompassing ampD and piuCD genes, which was likely selected by ceftazidime/avibactam treatment.
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
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