ansP2

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asparaginase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to ansP2

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Validation StatusCandidate

Overview

Mechanism: mutant alleles contribute to pyrazinamide resistance via L-aspartate-based modulation of coenzyme-A pool
Validation Method: flux GWAS and pathway enrichment
Drug Classes: pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

A biochemically-interpretable machine learning classifier for microbial GWAS.

PMID 32444610 · 2020

The study identifies pncA, ppsA, ansP2, thyA, cysK2, and katG as key genetic determinants of pyrazinamide, para-aminosalicylic acid, and isoniazid resistance in Mycobacterium tuberculosis using a metabolic allele classifier (MAC).

Gene Information

Gene Name: ansP2
Allele: ansP2
Encodes: asparaginase
Source Database: Reslit
Mechanism: mutant alleles contribute to pyrazinamide resistance via L-aspartate-based modulation of coenzyme-A pool
Confers Resistance To: pyrazinamide
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: flux GWAS and pathway enrichment

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ansP2

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ansP2

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