The study identified aminoglycoside-modifying enzymes aac(6')-Ib and ant(2")-Ia as contributors to tobramycin resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

The study identifies multiple resistance mechanisms in a multidrug-resistant Pseudomonas aeruginosa epidemic clone, including mutations in gyrA and parC, overproduction of the MexAB-OprM efflux system, and the presence of the ANT(2")-I aminoglycoside modifying enzyme.

The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.

The study identified aminoglycoside resistance mechanisms in Gram-negative bacteria, including aac(3)-I, aac(6')-I, ant(2")-I, and aph(3')-I genes, which confer resistance to various aminoglycosides.

The study characterizes three aminoglycoside resistance-causing enzymes: APH(3')-IIIa, ANT(2'')-Ia, and AAC-(3)-IV, which modify aminoglycoside antibiotics, leading to reduced susceptibility.

The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.

The study identified numerous aminoglycoside and β-lactam resistance gene homologues in the gut microbiota of healthy adults, indicating that the human gut microbiota serves as a reservoir for antibiotic resistance genes even in the absence of recent antibiotic exposure.

The study found a high frequency of aac(3)-IIa and ant(2'' )-Ia genes in uropathogenic E. coli isolates, which are associated with resistance to multiple aminoglycosides.

The study identified a diverse array of antibiotic resistance genes in a polluted lake in India, including sul2, qnrD, aph(6)-Id, aph(3′)-Ib, CMY2, qnrS, ant(3′)-Ia, dfrB1/dfrB5/dfrB6/dfrB8, GES, ere(A)/ere(C), qnrC, mph(E), dfrA1/dfrA15/dfrA25/dfrA30, erm(F), ant(2′)-Ia, cmlA, and tet(39). These genes conferred resistance to various classes of antibiotics, highlighting the significant presence of resistance mechanisms in the polluted environment.

The study characterizes the structural and mechanistic basis for adenylylation of aminoglycosides by the ANT(2""-Ia enzyme, which confers resistance to gentamicin, tobramycin, and kanamycin.

The study characterizes the resistance genetic determinants of the hypervirulent Acinetobacter baumannii strain LAC-4, identifying multiple beta-lactamases, aminoglycoside modifying enzymes, and RND-type efflux pumps contributing to its multidrug resistance.

The study identified several AMR genes, including bla CTX-M, bla TEM, armA, aadA2, aac(6')-Ib-cr, and ant(2")-Ia, in Enterobacter cloacae isolates from Algeria and France, highlighting the prevalence of multidrug resistance in these isolates.

The study identifies several AMR genes including blaGES-1, blaKPC-2, blaSPM-1, aac(6')-Ib, ant(2')-Ia, aph(3')-VIa, rmtD, catB3, arr-4, qacED1, sul1, and intI1, as well as mutations in the oprD gene contributing to carbapenem resistance in multidrug-resistant P. aeruginosa isolates from Recife, Brazil.

The study identifies specific genomic islands (GIs) in the Pseudomonas aeruginosa ST395 clone, including GI-7, which contains genes for copper resistance (copA and copB). Additionally, chromosomal mutations in genes such as mexZ, gyrA, parC, ampR, ampD, mexR, mexS, and ampC contribute to multidrug resistance.

The study identified five aminoglycoside-modifying enzyme (AME) genes, including aac(3)-II, aac(6′)-I, aac(6′)-II, ant(2″)-I, and ant(3″)-I, in aminoglycoside-resistant Pseudomonas aeruginosa strains. These genes were detected using PCR and gel electrophoresis.

The study found high frequencies of aac(6')-IIa, ant(2")-Ia, and intl1 genes in aminoglycoside-resistant Klebsiella pneumoniae isolates from Yazd, Iran, indicating their potential role in antibiotic resistance.

The paper discusses the antimicrobial resistance mechanisms in Acinetobacter spp. and Pseudomonas spp., focusing on the identification of resistance genes such as blaOXA-23, blaOXA-51, aac(6')-Ib, aac(3')-I, aph(3')-VI, ANT(2'')-I, ArmA, and efflux pumps like MexAB-OprM and MexXY-OprM. It also highlights mutations in gyrA and parC contributing to fluoroquinolone resistance.

The study demonstrates the co-occurrence of different carbapenemase encoding genes in single isolates of Acinetobacter baumannii, highlighting the presence of multiple clones within a single sample.

The study identifies several AMR genes including aac(3)-IIa, aac(6')-lb-cr, ant (2")-Ia, aph3'-1, dfrA14, dfrA17, sul1, and qnrB19, which confer resistance to Tobramycin, Ciprofloxacin, and Trimethoprim-Sulfamethoxazole. These genes were validated through cloning and MIC testing.

The study identifies several AMR genes including aac(3)-IIa, aac(6')-lb-cr, ant (2")-Ia, aph3'-1, dfrA14, dfrA17, sul1, and qnrB19, which confer resistance to Tobramycin, Ciprofloxacin, and Trimethoprim-Sulfamethoxazole. These genes were validated through cloning and MIC testing.

The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.

The study reports the first complete genomic sequence of an mcr-9 and bla VIM-4 -carrying multidrug-resistant Enterobacter hormaechei clinical isolate from Egypt, highlighting the coexistence of these resistance genes on an IncHI2 plasmid and their potential for dissemination.

The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.

The study reports the first autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 strain in Italy, highlighting the presence of multiple beta-lactamase genes, aminoglycoside modifying enzymes, and multidrug efflux pumps contributing to its extensive drug resistance.

The study identified several AMR genes in multidrug-resistant Pseudomonas sp. isolates from water sources, including blaGES, qnrS, qepA, tetB, aac(3')-IIa, and ant(2'')-Ia, which confer resistance to various antibiotics.

The study identified several AMR genes associated with different antimicrobial classes in swine fecal samples from farms with varying antimicrobial usage levels. These genes included beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, macrolide resistance markers, polymyxin resistance genes, phenicol resistance genes, and trimethoprim resistance genes.

The study identified aac(3)-Ia and ant(2")-Ia as important aminoglycoside resistance genes in Pseudomonas aeruginosa isolates from a cystic fibrosis center, highlighting the role of these genes in resistance to gentamicin and tobramycin.

The study identifies various aminoglycoside modifying enzymes (AMEs) in gram-negative bacteria causing human infections, including aac(6′)-lb, aac(3′)-I, aph(3′)-VI, aac(3′)-II, ant(2′)-I, ant(4′)-IIb, aph(2′)-Ib, aph(2′)-Ic, aph(2′)-Id, aac(6′)-Ie-aph(2′)-Ia, and aph(3′)-IIIa. These AMEs confer resistance to multiple aminoglycosides such as amikacin, gentamicin, tobramycin, and netilmicin.

The study identified 60 antimicrobial resistance genes (ARGs), 4 disinfectant resistance genes (DRGs), and 33 heavy metal resistance genes (HMRGs) in 450 Salmonella strains isolated from diseased animals. These genes contributed to resistance against multiple antimicrobial classes, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and phenicols.

The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.

The study identified 18 antibiotic resistance genes in the multidrug-resistant Proteus mirabilis strain CC15031, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and others.

The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.

Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.

The study characterizes two clinical Enterobacter cloacae complex isolates co-producing VIM and MCR enzymes, identifying specific AMR genes and their resistance mechanisms.

This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.

The study developed a targeted LC-MS/MS assay for the rapid and accurate detection of aminoglycoside-modifying enzymes and 16S rRNA methyltransferases in E. coli and K. pneumoniae, demonstrating high sensitivity and specificity for detecting resistance mechanisms to gentamicin, tobramycin, and amikacin.

The study identified several AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Vietnam, including bla OXA-51-like, bla OXA-23, bla TEM-1, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, and other antibiotics.

The study identifies a novel blaKPC-2 plasmid (pP33-2) and an integrative and conjugative element (ICEP33) carrying Tn6203 in multidrug-resistant Pseudomonas aeruginosa strains. The plasmid pP33-2 is distinct from previously reported blaKPC-2 plasmids and is not transferable. ICEP33 contains resistance genes including aac(6')-IIa, ant(2")-Ia, blaCARB-2, and sul1, contributing to multidrug resistance.

The study identifies several antibiotic resistance genes in Arthrobacter nicotianae OTC-16, including ant2ia, sul1, tet33, cml_e8, and tetV, which confer resistance to various antibiotics such as tetracyclines, sulfonamides, aminoglycosides, and chloramphenicol.

The study identified several aminoglycoside-modifying enzyme-encoding genes, including AAC(6')-Ib, AAC(6')-IIa, APH(3')-IIb, ANT(3'')-Ia, and ANT(2'')-Ia, which are associated with resistance to aminoglycosides in Pseudomonas aeruginosa isolates from the north of Iran.

The study identifies bla(VIM-2) and bla(KPC-2) genes in multidrug-resistant Pseudomonas aeruginosa isolates from Colombia, highlighting their diverse genetic environments and mechanisms of resistance.

The study identified several AMR genes and mutations in Pseudomonas aeruginosa isolates from the Philippines, including bla VIM-2, bla VIM-6, bla NDM-1, bla IMP-26, aac(6')-Ib, aac(6')-Ib4, aac(6')-IIa, aac(6')-31, ant(2")-Ia, aadA1, acc(6')-Ib, qnrVC, gyrA, parC, oprD, nalC, and nalD. These genes and mutations were associated with resistance to carbapenems, aminoglycosides, and fluoroquinolones.

The study identifies aminoglycoside-resistance genes such as aac(6')-Ib, aac(6')-Ib', aac(3)-II, aac(3)-IV, ant(2'')-I, aph(3')-I, and rmtF as significant predictors of aminoglycoside MICs in carbapenem-resistant Klebsiella pneumoniae.

The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.

The study identifies various AMR genes and mutations associated with colistin resistance in clinical Acinetobacter baumannii strains, highlighting the genomic diversity and mosaicism in resistance mechanisms.

The study identified several AMR genes and mutations in MDR P. aeruginosa isolates from Qatar, including blaVIM, blaOXA-50, aac(6')-Ib, aadA, ant(2')-Ia, aph(3')-IIb, qnrS1, crpP, gyrA(T83I), parC(S83I), parE(A473V), pbp3(D350N, S357N), and ompK37(M70I, M128I). These resistance mechanisms contribute to the multidrug-resistant phenotype observed in the isolates.

The study reports a Providencia rettgeri clinical isolate co-harboring blaNDM-1, blaVIM-1, and blaOXA-10, which conferred resistance to multiple antibiotics including carbapenems, ceftazidime-avibactam, and aminoglycosides.

The study identified various aminoglycoside-modifying enzymes (AMEs) and efflux pump genes contributing to tobramycin resistance in E. coli, K. pneumoniae, and A. baumannii. These genes include acc(3)-IIa, aac(6')-Ib-cr, ant(2")-Ia, aph(6)-Id, aph(3")-Ib, armA, rmtF, acrD, adeA, adeB, adeC, ompA, omp37, csgB, csgD, csgF, csgG, pgaA, pgaB, pgaC, pgaD, csuA, csuB, csuC, csuD, csuE, and bap.

The study identified multiple antimicrobial resistance genes in S. algae strains, including genes conferring resistance to beta-lactams, aminoglycosides, quinolones, phenicols, macrolides, sulfonamides, tetracyclines, and lincosamides.

The study identifies multiple antibiotic resistance genes in a Raoultella planticola isolate, including bla KPC-2, bla NDM-1, and tmexCD1-toprJ1, which confer resistance to carbapenems, cephalosporins, and tigecycline, respectively.

The study identified various AMR genes in two extensively drug-resistant A. baumannii isolates, including aminoglycoside resistance genes, sulfonamide resistance genes, beta-lactamase genes, and efflux pump genes, highlighting the complexity of their resistance mechanisms.

The paper discusses the mechanisms of bacterial resistance to aminoglycoside antibiotics, including enzymatic modification, decreased drug accumulation, and modification of drug targets. It highlights the importance of understanding these mechanisms to develop strategies to overcome resistance.

The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.

Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.

The study developed and validated a targeted LC-MS/MS assay for the rapid detection of β-lactam, aminoglycoside, and fluoroquinolone resistance mechanisms in blood cultures growing E. coli or K. pneumoniae. The assay successfully detected various resistance genes including β-lactamases (SHV, TEM, CTX-M-1-like, OXA-1, CMY-2-like, cAmpC, KPC, OXA-48, NDM, VIM), aminoglycoside-modifying enzymes (AAC(3)-Ia, AAC(3)-II, AAC(3)-IV, AAC(3)-VI, AAC(6′)-Ib, ANT(2′′)-I, APH(3′)-VI), 16S-RMTases (ArmA, RmtB, RmtC, RmtF), and quinolone resistance mechanisms (QnrA, QnrB, AAC(6′)-Ib-cr, and wildtype QRDR of GyrA).

The study developed and validated a targeted LC-MS/MS assay for the rapid detection of β-lactam, aminoglycoside, and fluoroquinolone resistance mechanisms in blood cultures growing E. coli or K. pneumoniae. The assay successfully detected various resistance genes including β-lactamases (SHV, TEM, CTX-M-1-like, OXA-1, CMY-2-like, cAmpC, KPC, OXA-48, NDM, VIM), aminoglycoside-modifying enzymes (AAC(3)-Ia, AAC(3)-II, AAC(3)-IV, AAC(3)-VI, AAC(6′)-Ib, ANT(2′′)-I, APH(3′)-VI), 16S-RMTases (ArmA, RmtB, RmtC, RmtF), and quinolone resistance mechanisms (QnrA, QnrB, AAC(6′)-Ib-cr, and wildtype QRDR of GyrA).

The study demonstrates that aminoglycoside-modifying enzymes (AMEs) are sufficient to confer clinical resistance to key antibiotics in Pseudomonas aeruginosa. Specifically, ant(2")-Ia, aac(6')-Ib3, and aph(3')-VIa were shown to significantly increase the minimum inhibitory concentrations (MICs) of tobramycin, gentamicin, and amikacin, respectively.

The study identifies the co-production of chromosomal NDM-1 and OXA-820 carbapenemases in a carbapenem-resistant Acinetobacter pittii strain, along with other resistance genes such as blaADC-43, ble-MBL, sul2, msr(E), mph(E), and ant(2'')-Ia. A point mutation (S81L) in the gyrA gene was also found, contributing to fluoroquinolone resistance.

The study identified several aminoglycoside-modifying enzymes, including aac(3)-IId, aac(3)-VIa, aac(3)-IIa, aac(6′)-Ib-cr, aac(3)-IVa, ant(2″)-Ia, aadA5, aadA1, aadA2, aph(3″)-Ib, and strA, as key contributors to gentamicin and spectinomycin resistance in Escherichia coli from human and chicken sources in Canada.

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.

The study identified 40 antibiotic resistance genes (ARGs) in 19 Trueperella pyogenes strains, including genes conferring resistance to aminoglycosides, tetracyclines, phenicols, sulfonamides, and macrolides.

The study identifies multiple AMR genes, including blaNDM-1, blaOXA-10, blaPER-4, aph(3')-VI, ant(2'')-Ia, ant(3')-Ia, sul1, catB8, catA1, mph(E), and tet, in a multidrug-resistant Providencia rettgeri strain. These genes contribute to resistance against various antibiotics, including carbapenems, beta-lactams, aminoglycosides, sulfonamides, chloramphenicol, macrolides, and tetracyclines.

The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.

The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.

The study identified several aminoglycoside resistance genes, including ant(2'')-Ia, aac(3')-IIa, armA, aac(6')-Ib, and aph(3')-Ia, in Klebsiella pneumoniae isolates. These genes were associated with resistance to tobramycin and amikacin. Additionally, biofilm formation was significantly linked to antibiotic resistance.

The study identifies the role of acquired tobramycin resistance mechanisms, including the ant(2")-Ia, aph(3')-IIb, aac(6')-Ib3 genes, and the mexY gene encoding the MexXY-OprM efflux pump, in the transition of Pseudomonas aeruginosa to the viable but non-culturable (VBNC) state.

The study identifies 25 critical mobile antibiotic resistance genes (ARGs) in Pseudomonas aeruginosa, including genes such as sul1, qacEΔ1, aac(6′)-Ib, bla VIM-1, and others, which are associated with various antibiotic classes and are linked to mobile genetic elements (MGEs).

The study identifies several AMR genes in Wohlfahrtiimonas chitiniclastica, including macA, macB, tehB, tet(H), tet(B), ant(2″)-Ia, aac(6′)-Ib, ant(3″)-Ib, bla VEB-1, bla OXA-1, aph(3′)-Ib, sul2, strA, and dfrA1, which confer resistance to various antibiotics such as macrolides, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and trimethoprim.

The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.

The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.

The study identifies multiple AMR genes and mutations in Gram-negative bacteria causing neonatal sepsis in LMICs, including ESBLs, carbapenemases, and aminoglycoside-modifying enzymes, highlighting the high prevalence of multidrug resistance and the need for effective antibiotic combinations.

The study identifies aac(3)-IVa, aac(6)-Ib, and aac(3)-IIa as the most prevalent aminoglycoside resistance genes in E. coli isolates from bloodstream infections in Tehran, Iran.

The study identifies variations in antibiotic resistance and life-history traits among the mPact panel of Pseudomonas aeruginosa strains, highlighting the presence of specific AMR genes and mutations contributing to resistance against various antibiotics.

The study identifies variations in antibiotic resistance and life-history traits among the mPact panel of Pseudomonas aeruginosa strains, highlighting the presence of specific AMR genes and mutations contributing to resistance against various antibiotics.

The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.

The study identified multiple antimicrobial resistance genes and mutations in Pseudomonas aeruginosa isolates from Egyptian healthcare settings, highlighting extensive drug resistance and the role of mobile genetic elements in the spread of resistance.

The study identified aac(6')-Ib, ant(2'')-Ia, and aph(3')-VI as the primary aminoglycoside resistance genes in P. aeruginosa isolates from Ardabil hospitals, with aac(6')-Ib being the most prevalent.

The study identifies the NDM-1-producing Pseudomonas aeruginosa ST357 as an extensively drug-resistant strain with a unique resistome, highlighting the importance of tracking the origin of such isolates through genomic epidemiology.

The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.

The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.

The study identified multidrug-resistant Acinetobacter baumannii strains from a neonatal ICU in Egypt, highlighting the presence of various beta-lactamase genes, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and sulfonamide resistance genes.

The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.

This study identified 17 distinct antibiotic resistance genes across 53 P-type T4SS-encoding plasmids in Acinetobacter species, including various beta-lactamases, aminoglycoside modifying enzymes, and others, highlighting the significant diversity of resistance determinants carried by these plasmids.

The study shows that increasing microplastic diversity in soil leads to a significant increase in the abundance of antibiotic resistance genes (ARGs), including those conferring resistance to aminoglycosides, macrolide-lincosamide-streptogramin, florfenicol, and tetracycline.

The study identified multiple antimicrobial resistance (AMR) genes in Trueperella pyogenes, including tet(W/32/O), erm(X), vanG, sul1, and qacEdelta1, which confer resistance to tetracyclines, MLS B, glycopeptides, sulfonamides, and biocides, respectively. These genes were detected in various T. pyogenes isolates from different animal hosts and body sites, highlighting the genetic diversity and potential for AMR dissemination among different hosts.

The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.

The study identified multiple AMR genes and mutations in P. aeruginosa UTI isolates from the UK and Kuwait, highlighting the presence of multidrug-resistant strains, especially in Kuwaiti isolates. Key AMR genes included aac(3)-IV, aph(3')-Ib, aph(3')-IIb, aph(4)-Ia, aph(6)-Id, crpP, dfrB1, aac(6')-Ib7, aac(6')-ii, aaA61, blaPDC, and blaVIM-28. Mutations in gyrA were also found to contribute to fluoroquinolone resistance.

The study identified various AMR genes in ESKAPE pathogens, including vanA and vanC for vancomycin resistance, blaKPC and blaOXA-48 for carbapenem resistance, and others related to tetracycline, sulfonamide, quinolone, and aminoglycoside resistance. Additionally, biofilm-related genes such as icaA, icaD, gelE, asa1, and esp were detected in Staphylococcus and Enterococcus spp. Quorum sensing genes LasI and LasR were found in Pseudomonas aeruginosa, and biofilm production genes like mrkA, wbbM, wzm, and luxS were identified in Klebsiella pneumoniae.

The study identifies six pVir-CRKP isolates from the United States, highlighting their multidrug resistance and enhanced virulence traits. These isolates exhibit resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, due to the presence of specific AMR genes and mutations.

The study reports the isolation of a Pseudomonas guariconensis clinical isolate producing OXA-204 carbapenemase, highlighting the spread of OXA-48-like genes beyond Enterobacterales. The isolate exhibited resistance to multiple antibiotics due to the presence of various resistance genes, including blaOXA-204, blaCMY-16, blaDHA-1, and others.

The study characterizes the XDR plasmid p1AB5075, which harbors multiple antibiotic resistance genes, including blaGES-11, aac(6')-Ib10, ant(2")-Ia, aadA2, aph(3")-Ib, aph(6)-Id, cmlA1, dfrA7, sul1, and qacEΔ1, conferring resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, trimethoprim, and sulfonamides. The plasmid was successfully transferred to genetically diverse Acinetobacter strains, highlighting its potential for spreading resistance.

The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.

The study identified carbapenem-resistant Acinetobacter baumannii isolates carrying the blaOXA-23 gene and aminoglycoside resistance genes such as armA, aadA2, aph(3')-VIa, and ant(2")-Ia. Other resistance genes included mph(E), msr(E), sul1, sul2, and tet(B).

The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.

The paper discusses the identification of various AMR genes in Acinetobacter baumannii and other pathogens, highlighting their role in resistance to multiple antibiotics and the potential of phage therapy as an alternative treatment.

The study identifies several AMR genes in a multidrug-resistant K. quasipneumoniae subsp. similipneumoniae isolate, including blaSHV-18, blaOXA-2, sul1, ant(2")-Ia, and ompK36, which contribute to resistance against various antibiotics.

The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.

PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.