ant(3'')-IId

aminoglycoside nucleotidyltransferase ANT(3')-IId

Validation StatusConfirmed2+ DBs

Overview

Mechanism: adenylation of the 3'-OH position of the streptomycin glucosamine ring and the 9'-OH position of the spectinomycin actinamine ring
Validation Method: cloning in E. coli + MIC testing
Drug Classes: STREPTOMYCIN, SPECTINOMYCIN, streptomycin, spectinomycin, aminoglycosides
Organisms: Acinetobacter lwoffii, Acinetobacter lwoffii H7, Escherichia coli DH5alpha, Acinetobacter pittii
Geographic Location: China, Europe|Japan|Hong Kong|Mexico|US|China|Spain
Papers: 2
Databases: Reference Gene CatalogReslit

Papers2

Gene Information

Gene Name: ant(3'')-IId
Allele: ANT(3')-IId
Encodes: aminoglycoside nucleotidyltransferase ANT(3')-IId
Source Database: Reference Gene Catalog
Confers Resistance To: STREPTOMYCINSPECTINOMYCIN
Organisms Tested In: • Acinetobacter lwoffii
Sequence Accession: MW984426.1
Protein Accession: QUX80205.1

Identification and Characterization of a Novel Aminoglycoside 3''-Nucleotidyltransferase, ANT(3'')-IId, From Acinetobacter lwoffii.

PMID 34531844 · 2021

A novel aminoglycoside 3''-nucleotidyltransferase, ANT(3'')-IId, was identified in Acinetobacter lwoffii H7, which confers resistance to streptomycin and spectinomycin.

Gene Information

Gene Name: ant(3'')-IId
Allele: ANT(3')-IId
Encodes: aminoglycoside 3''-nucleotidyltransferase
Source Database: Reslit
Mechanism: adenylation of the 3'-OH position of the streptomycin glucosamine ring and the 9'-OH position of the spectinomycin actinamine ring
Confers Resistance To: streptomycinspectinomycin
Organisms Tested In: • Acinetobacter lwoffii H7
• Escherichia coli DH5alpha
Geographic Location: China
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: CP072549|CP072550|CP072551|CP072552|CP072553|CP072554|MW984426

Genomic and phenotypic characterization of six multidrug-resistant Acinetobacter pittii isolates.

PMID 40797094 · 2025

The study identified multiple beta-lactamase genes, including blaOXA-72, blaOXA-272, and blaOXA-255, which confer resistance to carbapenems. Additionally, other resistance genes such as blaADC-245, blaADC-150, and others were found to confer resistance to cephalosporins. Efflux pump genes like adeF, abaQ, and abeS were associated with resistance to fluoroquinolones and tetracyclines. The gene lpsB was linked to colistin resistance.

Gene Information

Gene Name: ant(3'')-IId
Allele: ANT(3')-IId
Encodes: adenylyltransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Acinetobacter pittii
Geographic Location: Europe|Japan|Hong Kong|Mexico|US|China|Spain
Validation Method: genomic analysis
Sequence Accession: CP118934.1|LC777725.1|PRJNA1193816

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ant(3'')-IId

aminoglycoside nucleotidyltransferase ANT(3')-IId

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ant(3'')-IId

AMR Rules

Browse AMR rules for ant(3'')-IId

Validation StatusConfirmed2+ DBs

Overview

Mechanism: adenylation of the 3'-OH position of the streptomycin glucosamine ring and the 9'-OH position of the spectinomycin actinamine ring
Validation Method: cloning in E. coli + MIC testing
Drug Classes: STREPTOMYCIN, SPECTINOMYCIN, streptomycin, spectinomycin, aminoglycosides
Organisms: Acinetobacter lwoffii, Acinetobacter lwoffii H7, Escherichia coli DH5alpha, Acinetobacter pittii
Geographic Location: China, Europe|Japan|Hong Kong|Mexico|US|China|Spain
Papers: 2
Databases: Reference Gene CatalogReslit

Papers2

PMID N/A

Gene Information

Gene Name: ant(3'')-IId
Allele: ANT(3')-IId
Encodes: aminoglycoside nucleotidyltransferase ANT(3')-IId
Source Database: Reference Gene Catalog
Confers Resistance To: STREPTOMYCINSPECTINOMYCIN
Organisms Tested In: • Acinetobacter lwoffii
Sequence Accession: MW984426.1
Protein Accession: QUX80205.1

Identification and Characterization of a Novel Aminoglycoside 3''-Nucleotidyltransferase, ANT(3'')-IId, From Acinetobacter lwoffii.

PMID 34531844 · 2021

A novel aminoglycoside 3''-nucleotidyltransferase, ANT(3'')-IId, was identified in Acinetobacter lwoffii H7, which confers resistance to streptomycin and spectinomycin.

Gene Information

Gene Name: ant(3'')-IId
Allele: ANT(3')-IId
Encodes: aminoglycoside 3''-nucleotidyltransferase
Source Database: Reslit
Mechanism: adenylation of the 3'-OH position of the streptomycin glucosamine ring and the 9'-OH position of the spectinomycin actinamine ring
Confers Resistance To: streptomycinspectinomycin
Organisms Tested In: • Acinetobacter lwoffii H7
• Escherichia coli DH5alpha
Geographic Location: China
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: CP072549|CP072550|CP072551|CP072552|CP072553|CP072554|MW984426

Genomic and phenotypic characterization of six multidrug-resistant Acinetobacter pittii isolates.

PMID 40797094 · 2025

Gene Information

Gene Name: ant(3'')-IId
Allele: ANT(3')-IId
Encodes: adenylyltransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Acinetobacter pittii
Geographic Location: Europe|Japan|Hong Kong|Mexico|US|China|Spain
Validation Method: genomic analysis
Sequence Accession: CP118934.1|LC777725.1|PRJNA1193816

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ant(3'')-IId

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ant(3'')-IId

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